DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde6b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_032832.2	Gene:	Pde6b / 18587	MGIID:	97525	Length:	856	Species:	Mus musculus

Alignment Length:	833	Identity:	271/833 - (32%)
Similarity:	441/833 - (52%)	Gaps:	96/833 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   394 SRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKC 458
            |..||.|::|...:||||:|:...:.:..:..|||:.:..:|:|||.|||:.:.|    :|:.:
Mouse    46 SLRELCQVEESAALFELVQDMQESVNMERVVFKILRRLCTILHADRCSLFMYRQR----NGIAE- 105

  Fly   459 LVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGY 521
            |.::||.|.|.|.:|:  :....|:......||.||||::.:.:|:.|..:...|:...|.||.|
Mouse   106 LATRLFSVQPDSLLEDCLVPPDSEIVFPLDIGIVGHVAQTKKMINVQDVAECPHFSSFADELTDY 170

  Fly   522 RTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQL--- 583
            .||.:|..||.:.. ||:.|...:||::|.||:..||.||:.||.|..:   |.::|..|.|
Mouse   171 VTKNILSTPIMNGK-DVVAVIMAVNKLDGPCFTSEDEDVFTKYLNFATL---NLKIYHLSYLHNC 231

  Fly   584 EIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQI----------------LLVHE 632
            |.:|.||||..|..:|||.:.||....:....:::.:.|:|..:                :|:.|
Mouse   232 ETRRGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCERYSVGLLDMTKEKEFFDVWPVLMGE 296

  Fly   633 ADKGS-----------FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPN 686
            |...|           |.:|.|:..:  .:|:.....:|....:.:..|:..:||.:|...|:.|
Mouse   297 AQPYSGPRTPDGREIVFYKVIDYILH--GKEDIKVIPTPPADHWALASGLPTYVAESGFICNIMN 359

  Fly   687 AYEDDRF---DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAI 748
            |..|:.|   :..:|: |.:..:::|.|.|.|...:|:||....|:.:...|...||..:|:...
Mouse   360 ASADEMFNFQEGPLDD-SGWVIKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDDQDEVLMESLTQ 423

  Fly   749 FCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYH----------------------ASATMDEAHRL 791
            |.|..:.||..|:|......::.:..:::.||                      |....||..::
Mouse   424 FLGWSVLNTDTYDKMNKLENRKDIAQDMVLYHVRCDKDEIQEILPTRDRLGKEPADCEEDELGKI 488

  Fly   792 RRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRN 856
            .:..:|....|.:::|.|.|:...:.:.:|..::|:.:|..|.:|.|..|||.|:|.||.|.||.
Mouse   489 LKEELPGPTKFDIYEFHFSDLECTELELVKCGIQMYYELGVVRKFQIPQEVLVRFLFSVSKAYRR 553

  Fly   857 VTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQ 921
            :|||||||.|||||.||.:|.|.:....:.::|..|::...||||:|||||||.:|:|:.:|||:
Mouse   554 ITYHNWRHGFNVAQTMFTLLMTGKLKSYYTDLEAFAMVTAGLCHDIDHRGTNNLYQMKSQNPLAK 618

  Fly   922 LYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESV 986
            |:.:|.:|.||.:....:|......|..||:...:..||.:::.||::||||:|||||..|.:.|
Mouse   619 LHGSSILERHHLEFGKFLLAEESLNIYQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIV 683

  Fly   987 SQPTSY-----WV----AEEPR-ALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEK 1041
            .:..:|     ||    .|..| .::.||.||.|||||||||||::.:||.||::||:||||:|:
Mouse   684 DESKNYEDKKSWVEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLER 748

  Fly  1042 QELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106
            ..|:..||.:|:|.|..|||.:||.|||.:|..:|:.|:...:::.|:.:.:::||..|..|||.
Mouse   749 TVLDQQPIPMMDRNKAAELPKLQVGFIDFVCTFVYKEFSRFHEEILPMFDRLQNNRKEWKALADE 813

  Fly  1107 VKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASE--AEVAVDSPSEKAS 1157
            .:.|.   :..|||::::            :|.|||.:  .||....|:.|:|
Mouse   814 YEAKV---KALEEEKKKE------------EDRVAAKKVGTEVCNGGPAPKSS 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	55/163 (34%)
		GAF	611..762	CDD:214500	39/180 (22%)
		PDEase_I	859..1094	CDD:278654	106/244 (43%)
Pde6b	NP_032832.2	GAF	71..230	CDD:214500	57/167 (34%)
		GAF	252..439	CDD:214500	42/189 (22%)
		PDEase_I	556..801	CDD:278654	106/244 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844396
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750