DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde9a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_036016291.1	Gene:	Pde9a / 18585	MGIID:	1277179	Length:	536	Species:	Mus musculus

Alignment Length:	352	Identity:	110/352 - (31%)
Similarity:	176/352 - (50%)	Gaps:	31/352 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly   791 LRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR 855
            :..||.|:          ||...:|.::.|.....|:.||..|..|.|:...|.||||.|..|||
Mouse   192 IEALRKPT----------FDVWLWEPNEMLSCLEHMYHDLGLVRDFSINPITLRRWLLCVHDNYR 246

  Fly   856 NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLA 920
            |..:||:||.|.|.|||::::......:.|.:::.|.|:...:||||||.|.||::||.|.:.||
Mouse   247 NNPFHNFRHCFCVTQMMYSMVWLCGLQEKFSQMDILVLMTAAICHDLDHPGYNNTYQINARTELA 311

  Fly   921 QLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLE 984
            ..|: .|.:|:||......||..|...|.|::..:.:.::.:.:...||:||:|.:.:....|.|
Mouse   312 VRYNDISPLENHHCAIAFQILARPECNIFASVPPEGFRQIRQGMITLILATDMARHAEIMDSFKE 376

  Fly   985 SVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITP 1048
            .:.  ...:..||...||:.:.:..||:|...:|.|:.:...|.:..|:|.|.|.||.| |.:.|
Mouse   377 KME--NFDYSNEEHLTLLKMILIKCCDISNEVRPMEVAEPWVDCLLEEYFMQSDREKSEGLPVAP 439

  Fly  1049 IDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVR-----DNRGHWIDLA---D 1105
              .|:|:|..: ...|:.||..:.:|::|...    ||.|:||...     ::|.|:.:|.   |
Mouse   440 --FMDRDKVTK-ATAQIGFIKFVLIPMFETVT----KLFPVVEETMLRPLWESREHYEELKQLDD 497

  Fly  1106 VVK-TKTSQD-QEPEEEQQQQNVISNG 1130
            .:| .|..|. |...||.::.|:...|
Mouse   498 AMKEVKAVQRVQAVAEEDRELNIWGPG 524

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	75/236 (32%)
Pde9a	XP_036016291.1	PDEase_I	250..478	CDD:395177	75/236 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820