Protein Alignment Pde11 and Pde8a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_032829.1
• Gene: Pde8a / 18584
• MGIID: 1277116
• Length: 823
• Species: Mus musculus
• Alignment Length: 779
• Identity: 166/779 - (21%)
• Similarity: 302/779 - (38%)
• Gaps: 165/779 - (21%)

  Fly   417 ELEVRTLCH-----KILQNVSIL-----LNADRGSL--FLVQG---RCNGPDGLKKCLVSKLFDV 466
            :::..|||.     |..:|..|:     ::.:..||  ||..|   |......:..|....|...
Mouse   133 QMDAETLCRSIRSSKFSENTVIVGVVRRVDKEESSLMPFLAAGFTRRFIENPNVMACYNELLQLA 197

  Fly   467 CPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQD---ERFNCEIDSLTGYRTKALLC 528
            |     .|:..|.::|..  ..:...:.:|.|.:.|..  :|   :..|...:|..||:
Mouse   198 C-----GEVRSQLKLRAC--NSVFTALEKSQEAIEITS--EDHIIQYANPAFESTMGYQ------ 247

  Fly   529 MPIKDSSGDVIG--VAQV-INKMNGECFSEID-----EKVFSSYLQFCGIGLRNAQLYEKSQLEI 585
                  ||::||  :||| ||:..|:....|:     :|.:.        |:.:.|  :|:...|
Mouse   248 ------SGELIGKELAQVPINEKKGDLLDAINSCVTVDKEWQ--------GVYHTQ--KKNGDNI 296

  Fly   586 KRNQVLLDLARMIFEEQSTIEHMV--FRIL---THMQSLIQCQRVQILLVHEADKGSFSRVFDFE 645
            ::|..::.    :..:...|.|.|  .|:.   ..:::..:|.:......::|.|....|....:
Mouse   297 QQNVKIIP----VIGQGGKIRHYVSIIRVCNGNNKVETTTECVQTDSQTDNQAGKHKDRRKHSMD 357

  Fly   646 ANDLSEEEATSRTSPYESR-----------FPINIGITGHVATTGETVNVPNAYEDDRFDASVDE 699
            |..:|     ||||...|:           ..|...||       :.:|:.||         ..|
Mouse   358 AKAVS-----SRTSDVSSQRRHSSLARIHSMMIEAPIT-------KVINIINA---------AQE 401

  Fly   700 NSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAI 764
            ||        .:.:..:|.:::.:::....::.....::|.:..:........|:......|..:
Mouse   402 NS--------PVPVTEALNRVLDILRTTELYSPQFNAQDDPHATDLVGGLMSDGLRRFSGNEYIL 458

  Fly   765 VAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHD---FKFD----DIHFEDDDTLKA 822
            .     :..|..||.:. ||....|     .||..:...:.:   :.||    ::..::...:..
Mouse   459 A-----TKNLPPLSNNL-ATPVSLH-----DVPPRIALAIENEEQWDFDIFELEVATQNRPLIYL 512

  Fly   823 CLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVT-YHNWRHAFNVAQMMFAILTTTQWWKIFG 886
            .|:.|......|........|..|...::.||.:.. |||..||.:|.......|:..:..:...
Mouse   513 GLKTFARFGMCEFLQCSETTLRSWFQMIESNYHSSNPYHNSTHAADVLHATAYFLSRDKIKETLD 577

  Fly   887 EIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHF----------DQCLMIL 940
            .|:.:|.:|....||:||.|..|||...|.:.||.||: |:.:|.||.          |||
Mouse   578 RIDEVAALIAATVHDVDHPGRTNSFLCNAGNQLAVLYNDTAVLESHHVALAFQLTLENDQC---- 638

  Fly   941 NSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP------- 998
                 .|...:..:||..:.:.:.|.:|:|::..:|:....|:.|:::|.:...:|||
Mouse   639 -----NIFKQMERNDYRTLRQSIIDMVLATEMTKHFEHVNKFINSINKPLTAQESEEPDRSLEDI 698

  Fly   999 ---------RALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNR 1054
                     |||::.|.:...|:|...:|.|.....|..:|.|:|.|.|.||| |::..:..:..
Mouse   699 KAMLKTPESRALIKRMMIKCADVSNPCRPLEHCIEWAARISEEYFSQTDEEKQ-LDLPVVMPVFD 762

  Fly  1055 EKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPE 1118
            .....:|..|::|||.....:::|:....| |..|::.:.||..:|..|.:  |...|....||
Mouse   763 RNTCSIPKSQISFIDYFITDMFDAWDAFVD-LPNLMQHLDDNFRYWKGLDE--KKLRSLRPPPE 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	41/187 (22%)
		GAF	611..762	CDD:214500	24/164 (15%)
		PDEase_I	859..1093	CDD:459723	70/260 (27%)
Pde8a	NP_032829.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55
		PleD	78..>165	CDD:442920	6/31 (19%)
		PAS	215..>320	CDD:441804	28/132 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	338..373		10/39 (26%)
		PDEase_I	550..800	CDD:459723	70/260 (27%)