DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde7a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001116231.1	Gene:	Pde7a / 18583	MGIID:	1202402	Length:	482	Species:	Mus musculus

Alignment Length:	334	Identity:	87/334 - (26%)
Similarity:	158/334 - (47%)	Gaps:	37/334 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   803 RLHDFKFDDIHFE----DDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVT-YHNW 862
            ::.::.||...|:    .:..:.....:|.....:|.||:|...|.|:|:.::::|.:.. |||.
Mouse   150 KVGNWNFDIFLFDRLTNGNSLVSLTFHLFSLHGLIEYFHLDMVKLRRFLVMIQEDYHSQNPYHNA 214

  Fly   863 RHAFNVAQMMFAIL-------TTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLA 920
            .||.:|.|.|...|       :.|.|       :.|..:|....|||||.|.|..|.||.:..||
Mouse   215 VHAADVTQAMHCYLKEPKLASSVTPW-------DILLSLIAAATHDLDHPGVNQPFLIKTNHYLA 272

  Fly   921 QLY-STSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLE 984
            .|| ::|.:|:||:...:.:|...|  :.::|..:....:...:...||:||::...:....|..
Mouse   273 TLYKNSSVLENHHWRSAVGLLRESG--LFSHLPLESRQEMEAQIGALILATDISRQNEYLSLFRS 335

  Fly   985 SVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ-ELNITP 1048
            .:.:...:......|.|:..|::...|:....:.||:.|:.::.|:.|||.|||:||: .|.::|
Mouse   336 HLDKGDLHLDDGRHRHLVLQMALKCADICNPCRNWELSKQWSEKVTEEFFHQGDIEKKYHLGVSP 400

  Fly  1049 IDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSD-KLEPLVEG-VRDNRGHWIDLADVVKTKT 1111
              :.:|:.| .:..:|:.|:..:..|::..:|..|| :|...:.| |..|:..|         |.
Mouse   401 --LCDRQTE-SIANIQIGFMTYLVEPLFTEWARFSDTRLSQTMLGHVGLNKASW---------KG 453

  Fly  1112 SQDQEPEEE 1120
            .|.|:|..|
Mouse   454 LQRQQPSSE 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	67/245 (27%)
Pde7a	NP_001116231.1	Endonuc-BglII	<51..128	CDD:286304
Pde7a	NP_001116231.1	PDEase_I	211..431	CDD:278654	63/231 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844400
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.750