Protein Alignment Pde11 and Pde4b

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001391715.1
• Gene: Pde4b / 18578
• MGIID: 99557
• Length: 736
• Species: Mus musculus
• Alignment Length: 822
• Identity: 177/822 - (21%)
• Similarity: 299/822 - (36%)
• Gaps: 220/822 - (26%)

  Fly   453 DGLK---KCLVSKLFDV--------------CPRSTVE----EMEQQDEVRVAWGTGIAGHVAES 496
            |.||   :|.:||.:..              |....::    ...|.:..|...|.||:
Mouse    14 DNLKDYFECSLSKSYSSSSYTLGIDLWRGRRCCSGNLQLPPLSQRQSERARTPEGDGIS------ 72

  Fly   497 GEPVNIP---------DAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGEC 552
             .|..:|         .....|.|:.|.....|   ::.|......|||.|:..|...:....|.
Mouse    73 -RPTTLPLTTLPSIAITTVSQECFDVENGPSPG---RSPLDPQAGSSSGLVLHAAFPGHSQRRES 133

  Fly   553 F-------SEIDEKVFSSYLQFCGIGLRNAQLYEK----------------SQLEIKRNQVLL-- 592
            |       .::..|..|          ||:.|..:                |...::.|..||
Mouse   134 FLYRSDSDYDLSPKAMS----------RNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTN 188

  Fly   593 ---------------DLARMIFEEQS-------TIEHMVFRILTHMQSLIQCQRVQIL-LVHEAD 634
                           .::|:..:|:|       |:|.:.:       .|.|.:.:|.. .|.|..
Mouse   189 LHGAPNKRSPAASQAPVSRVSLQEESYQKLAMETLEELDW-------CLDQLETIQTYRSVSEMA 246

  Fly   635 KGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDE 699
            ...|.|:.:.|...|||   .||:....|.:     |:.........|.:|:..:.||      |
Mouse   247 SNKFKRMLNRELTHLSE---MSRSGNQVSEY-----ISNTFLDKQNDVEIPSPTQKDR------E 297

  Fly   700 NSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAI 764
            ..  |.:.::.        ||.||.:|::. :.|:.|.     :..|    |:...|.....|.:
Mouse   298 KK--KKQQLMT--------QISGVKKLMHS-SSLNNTS-----ISRF----GVNTENEDHLAKEL 342

  Fly   765 VAMAKQSVTL-EVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL--RM 826
            ..:.|..:.: .|..|..:..:                                    .|:  .:
Mouse   343 EDLNKWGLNIFNVAGYSHNRPL------------------------------------TCIMYAI 371

  Fly   827 FLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIEC 890
            |.:.|.::.|.|..:....::::::.:|. :|.|||..||.:|||....:|:|.....:|.::|.
Mouse   372 FQERDLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLEI 436

  Fly   891 LALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSD 954
            ||.|.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|......|..||:..
Mouse   437 LAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIFQNLTKK 501

  Fly   955 DYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMSMTVC-D 1011
            ....:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:||  :|..| |
Mouse   502 QRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQVLR--NMVHCAD 564

  Fly  1012 LSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPI 1075
            ||..||..|:.::..|.:..|||:|||.|::. :.|:|   |..:....:...||.|||.|..|:
Mouse   565 LSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISP---MCDKHTASVEKSQVGFIDYIVHPL 626

  Fly  1076 YEAFATL--------SDKLE----------------PLVEGVRDNRGHWIDLADVVKTKTSQDQE 1116
            :|.:|.|        .|.||                ||.|..||.:| .::......|...:|.|
Mouse   627 WETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQG-LMEKFQFELTLEEEDSE 690

  Fly  1117 -PEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKAS 1157
             ||:|.:..:..|:.....:.|.:...|..|..:|..:|..|
Mouse   691 GPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKS 732

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	31/181 (17%)
		GAF	611..762	CDD:214500	31/151 (21%)
		PDEase_I	859..1093	CDD:459723	79/267 (30%)
Pde4b	NP_001391715.1	PDE4_UCR	166..281	CDD:465648	24/129 (19%)
		PDEase_I	405..645	CDD:459723	74/244 (30%)