DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde4a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_899668.1	Gene:	Pde4a / 18577	MGIID:	99558	Length:	844	Species:	Mus musculus

Alignment Length:	911	Identity:	177/911 - (19%)
Similarity:	314/911 - (34%)	Gaps:	277/911 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   469 RSTVEEMEQQDEV-----------RVAW-----GTGIAGHVAESGEPVNIP---------DAYQD 508
            ||....:|:.|.|           |::|     |||..|..:...|..|.|         |:...
Mouse    59 RSPHRPIERADAVDTGDRPGLRTTRMSWPSSFHGTGTGGGSSRRLEAENGPTPSPGRSPLDSQAS 123

  Fly   509 ERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGV-----AQVINKMNGECFSEIDEKVFSSYLQFC 568
            ........:.|..|.::.|..  .||..|:...     :.|.::.:||      :.:.:.:.|..
Mouse   124 PGLMLHAGAATSQRRESFLYR--SDSDYDMSPKTMSRNSSVASEAHGE------DLIVTPFAQVL 180

  Fly   569 GIGLRNAQLYEKSQLEIKRN------------------------QVLLDLARMIFEE-------- 601
            . .|||.    :|...:..|                        :....|||...||
Mouse   181 A-SLRNV----RSNFSLLTNVPIPSNKRSPLGGPPSVCKATLSEETCQQLARETLEELDWCLEQL 240

  Fly   602 -------------QSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEE 653
                         ....:.|:.|.|||:..:.:               |.::|.::.:|...:::
Mouse   241 ETMQTYRSVSEMASHKFKRMLNRELTHLSEMSR---------------SGNQVSEYISNTFLDKQ 290

  Fly   654 -------ATSRTSPYESRFPINI----------GITGHVATTGETVNVPNAYEDDRFDASVDENS 701
                   .|.|..|::...|..:          |:...|.|....:|||      ||....|:
Mouse   291 HEVEIPSPTPRQRPFQQPPPAAVQQAQPMSQITGLKKLVHTGSLNINVP------RFGVKTDQ-- 347

  Fly   702 CFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVA 766
                ..:|...::|           ::|:              ...|||
Mouse   348 ----EDLLAQELEN-----------LSKW--------------GLNIFC---------------- 367

  Fly   767 MAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACL--RMFLD 829
                     |..|....::                                    :|:  .:|.:
Mouse   368 ---------VSEYAGGRSL------------------------------------SCIMYTIFQE 387

  Fly   830 LDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLAL 893
            .|.:::|||..:.:..::|:::.:|. :|.|||..||.:|.|....:|.|.....:|.::|.||.
Mouse   388 RDLLKKFHIPVDTMMTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAA 452

  Fly   894 IIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYC 957
            :.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|......|..|||.....
Mouse   453 LFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEENCDIFQNLSKRQRQ 517

  Fly   958 RVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPRALLRAMSMTVC-DLSA 1014
            .:.:::.|.:|:||::.:.......  :....:.||..|.     .:...:||  :|..| |||.
Mouse   518 SLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLR--NMVHCADLSN 580

  Fly  1015 ITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPMMQVNFIDSICLPIYEA 1078
            .|||.|:.::..|.:.:|||:|||.|::. :.|:|   |..:....:...||.|||.|..|::|.
Mouse   581 PTKPLELYRQWTDRIMAEFFQQGDRERERGMEISP---MCDKHTASVEKSQVGFIDYIVHPLWET 642

  Fly  1079 FATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEP------------------EEEQQQQ 1124
            :|.| ....:.:::.:.||| .|...|.......:.::||                  |||.::.
Mouse   643 WADLVHPDAQDILDTLEDNR-DWYHSAIRQSPSPTLEEEPGVLSDPALPDKFQFELTLEEEDEED 706

  Fly  1125 NVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDD 1189
            ::...|         :..:|..:.....:...::..|.|...|            |...:.::..
Mouse   707 SLEVPG---------LPCTEETLLAPHDTRAQAMEQSKVKGQS------------PAVVEVAESL 750

  Fly  1190 NDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTASSCLSTPPPTGEDDSTPVSPLKTLQ 1254
            ....|.|....|::||..||...::.:......|.|.|..:..|...|....:...|...|..::
Mouse   751 KQETASAHGAPEESAEAVGHSFSLETSILPDLRTLSPSEEAQGLLGLPSMAAEVEAPRDHLAAMR 815

  Fly  1255 A 1255
            |
Mouse   816 A 816

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	28/142 (20%)
		GAF	611..762	CDD:214500	26/167 (16%)
		PDEase_I	859..1094	CDD:278654	73/245 (30%)
Pde4a	NP_899668.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..124		15/64 (23%)
		PDEase_I	418..659	CDD:278654	73/245 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	819..844
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844402
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750