DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde3b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_035185.2	Gene:	Pde3b / 18576	MGIID:	1333863	Length:	1099	Species:	Mus musculus

Alignment Length:	658	Identity:	129/658 - (19%)
Similarity:	227/658 - (34%)	Gaps:	193/658 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   663 SRFPINIGITGHVATTGETV------NVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLG-QI 720
            :|.||....|....|....:      :|.:|.:..::..:.|.|.|            :|.| ||
Mouse   510 NRSPIGFPDTTDFLTKPNIILHRSLGSVSSAADFHQYLRNSDSNLC------------SSCGHQI 562

  Fly   721 I---------GVIQLINKFNELD---FTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVT 773
            :         |......|..|.|   |:|...|.||.              .|:..:..|.:.:.
Mouse   563 LKYVSTCEPDGTDHPSEKSGEEDSSVFSKEPLNIVET--------------QEEETMKKACRELF 613

  Fly   774 LEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTL------------------ 820
            ||          .::|.:...:.|:..    .:...|.:..||.|:|
Mouse   614 LE----------GDSHLMEEAQQPNID----QEVSLDPMLVEDYDSLIEKMNNWNFQIFELVEKM 664

  Fly   821 ---------KACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNV-------- 868
                     :....:|.|...:|.|.|..:....:..:::..||::.|||..||.:|
Mouse   665 GEKSGRILSQVMYTLFQDTGLLETFKIPTQEFMNYFRALENGYRDIPYHNRVHATDVLHAVWYLT 729

  Fly   869 -----------------------------------------AQMMFAILTTTQWWKIFGEIECLA 892
                                                     ..|.:..|::.     ...:|.:|
Mouse   730 TRPIPGLPQIHNNHETETKADSDGRLGSGQIAYISSKSCCIPDMSYGCLSSN-----IPALELMA 789

  Fly   893 LIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-MILNSPGNQILANLSSDD 955
            |.:....||.||.|..|:|.:..::|.|.||: .|.:|:||..... :.|:.|....|.||...:
Mouse   790 LYVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLSRPEYNFLLNLDHME 854

  Fly   956 YCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTS---YWVAEEPRALLRAMSMTVCDLSAITK 1017
            :.|...::.:|||:|||..:|.....|....:...|   .|.:|..|.|:..:.:.:.|::...|
Mouse   855 FKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNSNGIEWSSENDRLLVCQVCIKLADINGPAK 919

  Fly  1018 PWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPI---YEAF 1079
            ..::..|..:.:.:||:|||| |:..|.: ||.........:|..:|.:||..|..|:   |:|.
Mouse   920 DRDLHLRWTEGIVNEFYEQGD-EEATLGL-PISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAA 982

  Fly  1080 ATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASE 1144
            ..|.              |.||:      |:...|.|.:::.              .|||....|
Mouse   983 GLLP--------------GQWIE------TEEGDDTESDDDD--------------DDDDGGGEE 1013

  Fly  1145 AEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAEENGH 1209
                :||..|:...|.:..........:......|..:     :::.:..:..:.:|:..:..|:
Mouse  1014 ----LDSDDEETEDNLNPKPQRRKGRRRIFCQLMHHLT-----ENHKIWKEIIEEEEEKCKAEGN 1069

  Fly  1210 DAEVDEAS 1217
            ..:||.||
Mouse  1070 KLQVDNAS 1077

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	23/117 (20%)
		PDEase_I	859..1094	CDD:278654	67/291 (23%)
Pde3b	NP_035185.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..29
		Interaction with RAPGEF3. /evidence=ECO:0000250	1..28
		DUF1109	60..241	CDD:284050
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	400..423
		Interaction with PIK3R6. /evidence=ECO:0000250	415..439
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	570..590		4/19 (21%)
		PDEase_I	712..986	CDD:278654	66/280 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844399
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850