DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde1c

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_006505793.1	Gene:	Pde1c / 18575	MGIID:	108413	Length:	861	Species:	Mus musculus

Alignment Length:	744	Identity:	170/744 - (22%)
Similarity:	276/744 - (37%)	Gaps:	173/744 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   629 LVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRF 693
            ||.:.::|..| |.|.:.|  .|..||...|.|             :..|...::..:...|.:.
Mouse   202 LVKQLERGEAS-VVDLKKN--LEYAATVLESVY-------------IDETRRLLDTEDELSDIQS 250

  Fly   694 DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTH 758
            ||...|     .|..|.......:|      .::.:.:|....|:..:.|:|       ||....
Mouse   251 DAVPSE-----VRDWLASTFTRQMG------MMLRRSDEKPRFKSIVHAVQA-------GIFVER 297

  Fly   759 MYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHD---FKFDDIHFED---D 817
            ||        :::..:..|||                 |.||...|.|   :.||.....:   |
Mouse   298 MY--------RRTSNMVGLSY-----------------PPAVIDALKDVDTWSFDVFSLNEASGD 337

  Fly   818 DTLKACLRMFLDL----DFVERFHIDYEVLCRWLLSVKKNY---RNVTYHNWRHAFNVAQMMFAI 875
            ..||.   :|.:|    |.:.||.|....|..::.:::..|   :| .|||..||.:|.|.:..:
Mouse   338 HALKF---IFYELLTRYDLISRFKIPISALVSFVEALEVGYSKHKN-PYHNLMHAADVTQTVHYL 398

  Fly   876 LTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMI 939
            |..|.......|:|..|:|.....||.:|.||.|:|.|:..|..|.||: .|.:|:||......:
Mouse   399 LYKTGVANWLTELEIFAIIFSAAIHDYEHTGTTNNFHIQTRSDPAILYNDRSVLENHHLSAAYRL 463

  Fly   940 LNSPGN-QILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLR 1003
            |..... .||.|||.||:.....::.:.:::||::.:|::......::.||.:   .|:|:||
Mouse   464 LQEDEEMNILVNLSKDDWREFRTLVIEMVMATDMSCHFQQIKAMKTALQQPEA---IEKPKAL-- 523

  Fly  1004 AMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFI 1068
            ::.:...|:|...|.|::..|....:..|||.|||.| .||.: |...:...|...:...||.||
Mouse   524 SLMLHTADISHPAKAWDLHHRWTMSLLEEFFRQGDRE-AELGL-PFSPLCDRKSTMVAQSQVGFI 586

  Fly  1069 DSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCK 1133
            |.|..|   .|..|:|..|.:|..:.|              ::||.....:.:...|.|::.|.|
Mouse   587 DFIVEP---TFTVLTDMTEKIVSPLID--------------ESSQTGGTGQRRSSLNSINSSDAK 634

  Fly  1134 ------AMSDDDVAASEAEVAVDSPSEKAS---------------VNGSNVANNSSNTNKKIAVA 1177
                  :.||.....:.:.:.||..|.||:               |.....|...:....::|.
Mouse   635 RSGVKSSGSDGSAPINNSVIPVDYKSFKATWTEVVQINRERWRAKVPKEEKAKKEAEEKARLAA- 698

  Fly  1178 SHPTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTASSCLSTPPPTGED 1242
                      ::...:.:|....||.....|......||..:.|.|.....         |.|::
Mouse   699 ----------EEKQKEMEAKSQAEQGTTSKGEKKTSGEAKSQVNGTRKGDN---------PRGKN 744

  Fly  1243 DSTPVSPLKTLQAKLVAANLNALQRQTSNQAQTQKQRCKSCDHSRSGLQVRKTSSLRGAQELDLD 1307
                            :....|.::|.:...:..|.:....|||.:|.:.:||         |..
Mouse   745 ----------------SKGEKAGEKQQNGDLKDGKNKADKKDHSNTGNESKKT---------DGT 784

  Fly  1308 SKTRNGTHAALCKST-----PVINNHSHH 1331
            .|..:|:.|....||     |||.....|
Mouse   785 KKRSHGSPAPSTSSTSRITLPVIKPPLRH 813

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	28/132 (21%)
		PDEase_I	859..1094	CDD:278654	74/236 (31%)
Pde1c	XP_006505793.1	PDEase_I_N	241..297	CDD:369905	13/73 (18%)
		PDEase_I	382..610	CDD:365964	74/237 (31%)
		PTZ00121	<698..>788	CDD:173412	21/134 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844401
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940