DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde1b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_032826.1	Gene:	Pde1b / 18574	MGIID:	97523	Length:	535	Species:	Mus musculus

Alignment Length:	371	Identity:	100/371 - (26%)
Similarity:	171/371 - (46%)	Gaps:	37/371 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   816 DDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSVKK---NYRNVTYHNWRHAFNVAQMMFAIL 876
            ||..|:..: .:......:.||.|....|..:|.:::.   .|:| .|||..||.:|.|.:...|
Mouse   175 DDHALRTIVFELLTRHSLISRFKIPTVFLMSFLEALETGYGKYKN-PYHNQIHAADVTQTVHCFL 238

  Fly   877 TTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMIL 940
            ..|.......|||.||:|.....||.:|.||.|||.|:..|..|.||: .|.:|:||......::
Mouse   239 LRTGMVHCLSEIEVLAIIFAAAIHDYEHTGTTNSFHIQTKSECAILYNDRSVLENHHISSVFRMM 303

  Fly   941 NSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAM 1005
            ......|..||:.|::..:..::.:.:|:||::.:|::......::.|...   .::.:||  ::
Mouse   304 QDDEMNIFINLTKDEFAELRALVIEMVLATDMSCHFQQVKTMKTALQQLER---IDKSKAL--SL 363

  Fly  1006 SMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDS 1070
            .:...|:|..||.|.:..|....:..|||.|||.| .||.: |...:.......:...|:.|||.
Mouse   364 LLHAADISHPTKQWSVHSRWTKALMEEFFRQGDKE-AELGL-PFSPLCDRTSTLVAQSQIGFIDF 426

  Fly  1071 ICLPIYEAFATLSDKLEPLVEGVRDNRG--------HW------IDLA----DVVKTKTSQDQEP 1117
            |..|   .|:.|:|..|..|:.:.|:..        .|      :|:.    |||..:.:..:..
Mouse   427 IVEP---TFSVLTDVAEKSVQPLADDDSKPKSQPSFQWRQPSLDVDVGDPNPDVVSFRATWTKYI 488

  Fly  1118 EEEQQQ-QNVISNGDCKAMSDDDVAASEAEVAVDSPSE-KASVNGS 1161
            :|.:|: :...::|....||.|:::..|.| |..||:| :.:.||:
Mouse   489 QENKQKWKERAASGITNQMSIDELSPCEEE-APSSPAEDEHNQNGN 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	70/235 (30%)
Pde1b	NP_032826.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		Calmodulin-binding. /evidence=ECO:0000255	27..47
		PDEase_I_N	80..136	CDD:285672
		PDEase_I	221..448	CDD:278654	70/236 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	444..474		3/29 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	495..535		12/40 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844388
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850