DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and Pde1a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001153054.1	Gene:	Pde1a / 18573	MGIID:	1201792	Length:	545	Species:	Mus musculus

Alignment Length:	659	Identity:	147/659 - (22%)
Similarity:	250/659 - (37%)	Gaps:	147/659 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 EQSTIEHMV----FRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPY 661
            |.:|.::::    .::...::.:::|      ||.:.:||..: |.|.:.|  .|..|:...:.|
Mouse    12 ENATYKYLIGEQTEKMWQRLKGILRC------LVKQLEKGDVN-VVDLKKN--IEYAASVLEAVY 67

  Fly   662 ESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQL 726
                   |..|..:..|          ||:..|...|.... :.|..|.......:|.:....:.
Mouse    68 -------IDETRRLLDT----------EDELSDIQTDSVPS-EVRDWLASTFTRKMGMMKKKPEE 114

  Fly   727 INKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRL 791
            ..||..:      .:.|:|       ||....||.|               :||          :
Mouse   115 KPKFRSI------VHAVQA-------GIFVERMYRK---------------NYH----------M 141

  Fly   792 RRLRVPSAVHFRLHD---FKFDDIHFED---DDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLS 849
            ..|..|:||...|.:   :.||.....:   :.:||..: .:|...|.:.||.|....|..:..:
Mouse   142 VGLTYPAAVIVTLKEVDKWSFDVFALNEASGEHSLKFMIYELFTRYDLINRFKIPVSCLIAFAEA 206

  Fly   850 VKKNY---RNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSF 911
            ::..|   :| .|||..||.:|.|.:..|:..|.......|:|.||::.....||.:|.||.|:|
Mouse   207 LEVGYSKHKN-PYHNLVHAADVTQTVHYIMLHTGIMHWLTELEILAMVFAAAIHDYEHTGTTNNF 270

  Fly   912 QIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVY 975
            .|:..|.:|.||: .|.:|:||......::......||.|||.||:..:..::.:.:|:||::.:
Mouse   271 HIQTRSDVAILYNDRSVLENHHVSAAYRLMQEEEMNILVNLSKDDWRDLRNLVIEMVLATDMSGH 335

  Fly   976 FKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDME 1040
            |::......|:.||...     .||...::.:...|:|...|.|::..|....:..|||.|||.|
Mouse   336 FQQIKNIRNSLQQPEGI-----DRAKTMSLILHAADISHPAKTWKLHYRWTMALMEEFFLQGDKE 395

  Fly  1041 KQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLE----PLVEGVRDNRGHWI 1101
             .||.: |...:...|...:...|:.|||.|..|   .|:.|:|..|    ||:|
Mouse   396 -AELGL-PFSPLCDRKSTMVAQSQIGFIDFIVEP---TFSLLTDSTEKIVIPLIE---------- 445

  Fly  1102 DLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANN 1166
                                                   .||:::.:....|..:::.|.:||::
Mouse   446 ---------------------------------------EASKSQSSNYGASSSSTMIGFHVADS 471

  Fly  1167 --SSNTNKKIAVASH-PTSTQPSDDDNDVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSST 1228
              .|||...:...|: |..:..:.|......:..|:.:|..|.....|...|.....||....:|
Mouse   472 LRRSNTKGSVCDGSYAPDYSLSAVDLKSFKNNLVDIIQQNKERWKELAAQGELDLHKNSEELGNT 536

  Fly  1229 ASSCLSTPP 1237
            ......|.|
Mouse   537 EEKHADTRP 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	29/150 (19%)
		PDEase_I	859..1094	CDD:278654	74/239 (31%)
Pde1a	NP_001153054.1	Calmodulin-binding	24..44		3/25 (12%)
		PDEase_I_N	77..133	CDD:369905	14/79 (18%)
		PDEase_I	218..434	CDD:365964	69/225 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	526..545		4/18 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010