DRSC/TRiP Functional Genomics Resources

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Protein Alignment Pde11 and pde-5

DIOPT Version :9

Sequence 1:NP_001286044.1 Gene:Pde11 / 35107 FlyBaseID:FBgn0085370 Length:1451 Species:Drosophila melanogaster
Sequence 2:NP_491544.3 Gene:pde-5 / 183125 WormBaseID:WBGene00016328 Length:728 Species:Caenorhabditis elegans


Alignment Length:773 Identity:237/773 - (30%)
Similarity:373/773 - (48%) Gaps:97/773 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   357 TGGASGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVR 421
            |.|.:||...|.|                     ....|..|:..|.:..|...:...|.:|...
 Worm    49 TSGGTGAWTEPDL---------------------SMKRRVILETSDNRTRILYEITQCCGQLIGT 92

  Fly   422 TLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWG 486
            .....|:||       |.|: |..:...||...|||...||..|..  .|:.....|.       
 Worm    93 NSIELIVQN-------DEGA-FSCRKTENGELKLKKVKTSKSADYI--QTIVNAGNQT------- 140

  Fly   487 TGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGE 551
                  :||.             .|..::||    ..|::                     :|..
 Worm   141 ------IAEI-------------HFYTQLDS----TEKSI---------------------VNAV 161

  Fly   552 CFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHM 616
            |........:|........|.....::|....:.|.:..|||:||.||.:..:::.::.:::...
 Worm   162 CTWAAATNYYSELYTHKQEGSDGQDIHENIAKQRKLSNFLLDVARSIFHDIVSMDAVIIKVMNFA 226

  Fly   617 QSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGET 681
            |.|:...|..:.||...:...::|:||....| .|....:.....|.||.::.||.|:||:|||.
 Worm   227 QKLVDADRASLFLVDSKNAQIYARIFDVGTGD-EEHVRVNSEGQKEIRFDMSKGIAGYVASTGEG 290

  Fly   682 VNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAF 746
            :|:.|||||:||:|.||..:.:..::||||.|. ..|.:|||:|::||.:.: ||:.||:..|.|
 Worm   291 LNIENAYEDERFNADVDSKTGYTTKTILCMPIL-IRGIVIGVVQMVNKHDGV-FTRQDEDAFEIF 353

  Fly   747 AIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDD 811
            |::||:.:|:..:|:|...:..|..|.||||:||:....||.::|:::.:.:.: ..|....|:.
 Worm   354 AVYCGLALHHAKLYDKIRRSEQKYRVALEVLAYHSVCNADEVNKLKKIEINNRI-VELETIDFNG 417

  Fly   812 IHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAIL 876
            :...:.:.....:.||..| |.:....|.|.|.|::|:|:||||.|.||||.|.::||..|||.|
 Worm   418 MRLSELEKPLYAVYMFKTL-FADTLRFDTEDLIRFVLTVRKNYRRVAYHNWAHGWSVAHAMFATL 481

  Fly   877 TTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILN 941
            ..:.  ..|.::|.|||.:.||||||||||.||::....|:|||.:||||.||.|||:|.:.||.
 Worm   482 MNSP--DAFTKLEALALYVSCLCHDLDHRGKNNAYMKTMSTPLASIYSTSVMERHHFNQTVTILQ 544

  Fly   942 SPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAMS 1006
            ..|:.||.:|||:||.:.:.:::..||:||||::|..:......:...|.....:|.|.|.:|:.
 Worm   545 QDGHNILKSLSSEDYKKTLSLIKHCILATDLALFFSNKAKLNVILDNNTFDINRQEHRLLTQAVM 609

  Fly  1007 MTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSI 1071
            ||.|||.|..|||.|:.....::..||::|||.|:.. ...||.:|:|::...||.|||.|:..|
 Worm   610 MTGCDLVASAKPWNIQTETVKVIFEEFYDQGDAERLS-GKEPIPMMDRQQAHMLPQMQVGFMRGI 673

  Fly  1072 CLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISN 1129
            |:|.|:..|.:..|.:.:.|....|...|.:||:       :.::.:|...|||..:|
 Worm   674 CMPCYDLIARIFPKNDKMRERCEYNAKKWEELAE-------EQRKKQEALAQQNGEAN 724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Pde11NP_001286044.1 GAF 420..582 CDD:214500 27/161 (17%)
GAF 611..762 CDD:214500 55/150 (37%)
PDEase_I 859..1094 CDD:278654 97/234 (41%)
pde-5NP_491544.3 GAF 221..371 CDD:214500 56/152 (37%)
PDEase_I 464..696 CDD:278654 97/234 (41%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 216 1.000 Domainoid score I1562
eggNOG 1 0.900 - - E1_KOG3689
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D114875at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm14528
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4714
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.850

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