DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde-2

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_001022705.2	Gene:	pde-2 / 176270	WormBaseID:	WBGene00011146	Length:	831	Species:	Caenorhabditis elegans

Alignment Length:	1001	Identity:	229/1001 - (22%)
Similarity:	380/1001 - (37%)	Gaps:	272/1001 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   306 SCSNLQNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSLG 370
            :|.|.|...|:           |||:|.             .|.||:..|.....:||..|.|
Worm    20 NCQNSQRGDGL-----------HHHHHE-------------AASGSTCCGGMTVFTGANAAKS-- 58

  Fly   371 GSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILL 435
            .:..||:.....:......|...:.||.:.                            :|:.:.|
Worm    59 SNEPAGSASPTVWRKTSHPPLHFNNNETRN----------------------------RNLQMQL 95

  Fly   436 NADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAE---SG 497
            . :||:                                    :|:    ||..:...:.|   ||
Worm    96 K-NRGT------------------------------------KDD----WGASLRYDIEEPTSSG 119

  Fly   498 EPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFS 562
            ....:||.           .:....::.|:.|   |...|...||.          :|.|..|.|
Worm   120 LLELLPDV-----------PIVRKLSRPLVKM---DDQDDACSVAS----------NESDRTVLS 160

  Fly   563 SYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILT-HMQSLIQCQRVQ 626
            ..:..                             .||::        |..|| ::.:||.|
Worm   161 PLVPM-----------------------------SIFDQ--------FLCLTNNLSALISC---- 184

  Fly   627 ILLVHEADKGSFSRVFDFEAND--------------LSEEEATSRTSPYESRFPINIGITGHVAT 677
              ::.||.|.:       ||.|              |...|....|.   .:|.:..||.|.||:
Worm   185 --IIAEAKKNT-------EAEDYAVFLHDEDNKQMVLFNNETMLMTG---KKFDMGYGIVGKVAS 237

  Fly   678 TGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENF 742
            |..|:|:.:......|:..:||....|.|:::...:.:|...:||||.|.||.|  .|:::||.:
Worm   238 TMRTMNIRDVSRCPFFNEEIDEQFSIKARNLIAFPLIDSSCSLIGVIVLYNKEN--GFSRHDEKY 300

  Fly   743 VEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYH---------ASATMDEAHRLRRLRVPS 798
            ::.|:.|....|.:      ||:|...:.|...:   |         ..|.::|...:|.:..|
Worm   301 IKRFSYFVANSIAH------AILAKQIEEVRTRI---HMVEEFKIQGEDAVIEEVDIMRLVNDP- 355

  Fly   799 AVHFRLHDFKFDDIHFED----------DDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKN 853
                 |.|:::...:|.|          :...:|.:..|.||.|...:.::...|...:|.|...
Worm   356 -----LRDWRYFSQNFADFSFPPRSVGENHFHRASMMFFEDLGFSMLYKLNKRKLSYLVLRVSAG 415

  Fly   854 YRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKA--S 916
            ||.|.||||.|||.|....:..|.|....:...::|.|:|:|.|||||:|||||.||||:::  .
Worm   416 YRPVPYHNWSHAFAVTHFCWLTLRTDAIRRALSDMERLSLLIACLCHDIDHRGTTNSFQMQSLQK 480

  Fly   917 SPLAQLYST--STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKR 979
            :||:.||||  |.:|.|||.|.:.:|......||.||.:.|:..::..:.:.||:||::.:.:|:
Worm   481 TPLSVLYSTEGSVLERHHFAQTIKLLQQEECSILENLPAADFRTIVNTIREVILATDISAHLRKQ 545

  Fly   980 GPFLESVSQ---PTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEK 1041
            ......:|:   |.|:    :.|.||..:.||..|||...|.:...||:|:.:..|||.|||:|.
Worm   546 ERIKTMISEGYNPMSF----DHRYLLMCLVMTASDLSDQAKNFHNAKRIAENIYLEFFAQGDLEL 606

  Fly  1042 QELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV 1106
            | |.:.|:::|:|... .:|.:|::|:..|.:|:::..|::..:.....|.:..|...|:.|.:.
Worm   607 Q-LGVKPLEMMDRTNA-YVPTVQIDFLFKIGVPVFQLLASVVPEGRTTSEAIDANHLCWVALDEE 669

  Fly  1107 VKTKTS---------------------QDQEPE----EEQQQQNVISNGDCKAMSDDDVAASEAE 1146
            |:...|                     :.|:|.    ..::.:.|.:||......|      ..:
Worm   670 VRNNPSATNTLEYLRDENLERRIYDRVRKQDPRAAEIASKRFEPVYANGSVPQTQD------ILD 728

  Fly  1147 VAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQAAEENGHDA 1211
            ...|...:|..: |.:...|.|| .|:..:.|.......:.:|:.:....|:....||......:
Worm   729 HRFDGYDKKYQI-GCSGGQNQSN-GKQQQIRSLQKIRSKTSEDDALLKPMDNGGSVAASSTRRGS 791

  Fly  1212 EVDEASCRSNSTCSSSTASSCLSTPP 1237
            .......|......||.:|||.|..|
Worm   792 RTPRRLWRRARQLISSMSSSCASCSP 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	22/164 (13%)
		GAF	611..762	CDD:214500	43/165 (26%)
		PDEase_I	859..1094	CDD:278654	85/241 (35%)
pde-2	NP_001022705.2	GAF	177..322	CDD:214500	44/168 (26%)
pde-2	NP_001022705.2	PDEase_I	421..657	CDD:278654	85/241 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160163378
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.850