DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and pde-4

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_871945.1	Gene:	pde-4 / 174235	WormBaseID:	WBGene00020114	Length:	674	Species:	Caenorhabditis elegans

Alignment Length:	385	Identity:	109/385 - (28%)
Similarity:	179/385 - (46%)	Gaps:	51/385 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   772 VTLEVLSYHASATMDEAHRLRRLRVPS----------------AVHF-RLHD-----FKFDDIHF 814
            :||.:|....:|.|::...:|:||.||                |||. ||.|     ||.|::..
Worm   298 MTLSILKKAQTAAMNKISGVRKLRAPSHDGHVPEYGVNCAREIAVHMQRLDDWGPDVFKIDELSK 362

  Fly   815 EDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTT 879
            ....|: ....:....:..:.|.|....|..:||:::.:|||..|||:.||.:|||.|..:|.:.
Worm   363 NHSLTV-VTFSLLRQRNLFKTFEIHQSTLVTYLLNLEHHYRNNHYHNFIHAADVAQSMHVLLMSP 426

  Fly   880 QWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSP 943
            ...::|.::|.||.|.....||:||.|..|.:.|.:::.||.:|: .|.:|.||......:|...
Worm   427 VLTEVFTDLEVLAAIFAGAVHDVDHPGFTNQYLINSNNELAIMYNDESVLEQHHLAVAFKLLQDS 491

  Fly   944 GNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVA----------EEP 998
            ....|||||.....:..:::.|.:|:||::.:..........|....   ||          .:.
Worm   492 NCDFLANLSRKQRLQFRKIVIDMVLATDMSKHMSLLADLKTMVEAKK---VAGNNVIVLDKYNDK 553

  Fly   999 RALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQ-ELNITPI-DIMNREKEDELP 1061
            ..:|::| :.:.|||..|||.|:.::....:..|::.|||.||: .|.|:|: |..|...|..
Worm   554 IQVLQSM-IHLADLSNPTKPIELYQQWNQRIMEEYWRQGDKEKELGLEISPMCDRGNVTIEKS-- 615

  Fly  1062 MMQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWI-----DLADVVKTKTSQDQ 1115
              ||.|||.|..|:||.:|.| ....:.:::.:.:|| .|.     :..|..:|.|..|:
Worm   616 --QVGFIDYIVHPLYETWADLVYPDAQNILDQLEENR-EWYQSRIPEEPDTARTVTEDDE 672

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500
		PDEase_I	859..1094	CDD:278654	74/248 (30%)
pde-4	NP_871945.1	PDEase_I	406..647	CDD:278654	74/248 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920