Protein Alignment Pde11 and Pde5a

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_006233322.1
• Gene: Pde5a / 171115
• RGDID: 620995
• Length: 865
• Species: Rattus norvegicus
• Alignment Length: 969
• Identity: 419/969 - (43%)
• Similarity: 557/969 - (57%)
• Gaps: 166/969 - (17%)

  Fly   199 MEAWLDENQEFVQDYFIRKATRQTVDAW--------------LVSHATSAGNDVVSSTSPTHANG 249
            :|||||::::|...||:|||||..|:||              :.:|..|....:..|   .||:.
  Rat    20 VEAWLDDHRDFTFSYFVRKATRDMVNAWFSERVHNIPVCKEGIRAHTESCSCSLPQS---PHADN 81

  Fly   250 QTSSSRGGSGATTPVRKISAHEFERGGLLKPI-VNTIDGTPTFLSIGPPMDNGSVGGSCSNLQNV 313
            .|..:        |.|||||.||:|.  |:|| |...:||.:|||     |:|..
  Rat    82 TTPGA--------PARKISASEFDRP--LRPIVVKDSEGTVSFLS-----DSGKK---------- 121

  Fly   314 GGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGAGGAPSLGGSGGAGNG 378
                                                                             
  Rat   122 ----------------------------------------------------------------- 121

  Fly   379 HQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLF 443
                    .|.|....|.:..:.|:...:.||||||.:.|:|..|||||..::..|::|||.|||
  Rat   122 --------EQMPLTSPRFDSDEGDQCSRLLELVKDISSHLDVTALCHKIFLHIHGLISADRYSLF 178

  Fly   444 LVQGRCNGPDGLK-KCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQ 507
            ||   |.  |..| |.|||:||||...||:|| ...:.:|:.|..||.||||..|||:||.|||:
  Rat   179 LV---CE--DSSKDKFLVSRLFDVAEGSTLEE-ASNNCIRLEWNKGIVGHVAAFGEPLNIKDAYE 237

  Fly   508 DERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKM--NGECFSEIDEKVFSSYLQFCGI 570
            |.|||.|:|.:|||:|:::||||||:...:|:||||.|||.  ||..|:|.|||.|::||.||||
  Rat   238 DPRFNAEVDQITGYKTQSILCMPIKNHREEVVGVAQAINKKSGNGGTFTEKDEKDFAAYLAFCGI 302

  Fly   571 GLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADK 635
            .|.||||||.|.||.||||||||||.:|||||.::|.::.:|...:.|.:|.|:..|.:|.|...
  Rat   303 VLHNAQLYETSLLENKRNQVLLDLASLIFEEQQSLEVILKKIAATIISFMQVQKCTIFIVDEDCP 367

  Fly   636 GSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDEN 700
            .||||||..|..::. :.:...|..:::. .||.....:|..|.|.:|:|:..:|:||..: :||
  Rat   368 DSFSRVFQMEWEEVG-KSSEPLTREHDAN-KINYMYAQYVKNTMEPLNIPDVTKDNRFPWT-NEN 429

  Fly   701 ------SCFKHRSILCMAIKN-SLGQIIGVIQLINKFNELD-----FTKNDENFVEAFAIFCGMG 753
                  .|.  .|:||..||| ...::|||.||:||..|..     |.:|||.|:|||.||||:|
  Rat   430 MGHISTHCI--GSLLCTPIKNGKKNKVIGVCQLVNKMEEKTGKIKAFNQNDEQFLEAFVIFCGLG 492

  Fly   754 IHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR---VPSAVHFRLHDFKFDDIHFE 815
            |.||.|||....|||||.||||||||||||..:|...|:.|.   ||||...::.||.|.|....
  Rat   493 IQNTQMYEAVERAMAKQMVTLEVLSYHASAAEEETRELQALAAAVVPSAQTLKITDFSFSDFELS 557

  Fly   816 DDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTTT 879
            |.:|....:|||.||:.|:.|.:.:||||||:|||||||| ||.|||||||||.||.|||.|...
  Rat   558 DLETALCTIRMFTDLNLVQNFQMKHEVLCRWILSVKKNYRKNVAYHNWRHAFNTAQCMFAALKAG 622

  Fly   880 QWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPG 944
            :......::|.|||:|..|.|||||||.|||:..::..||||||..|||||||||||||:|||||
  Rat   623 KIQNKLTDLETLALLIAALSHDLDHRGVNNSYIQRSEHPLAQLYCHSTMEHHHFDQCLMVLNSPG 687

  Fly   945 NQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP--RALLRAMSM 1007
            ||||:.||.::|...:::::.|||:||||:|.|:||.|.|.:.:  :.:..|:|  :.|..||.|
  Rat   688 NQILSGLSIEEYKTTLKIIKQAILATDLALYIKRRGEFFELIRK--NEFSFEDPLQKELFLAMLM 750

  Fly  1008 TVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSIC 1072
            |.||||||||||.|::|:|:||::|||:|||.|::|||:.|.|:|||||::::|.|||.|||:||
  Rat   751 TACDLSAITKPWPIQQRIAELVAAEFFDQGDRERKELNMEPADLMNREKKNKIPSMQVGFIDAIC 815

  Fly  1073 LPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGD 1131
            |.:|||...:|:...||::|.|.||..|..|||                ||:..:.||:
  Rat   816 LQLYEALTHVSEDCLPLLDGCRKNRQKWQALAD----------------QQEKTLLNGE 858

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	91/164 (55%)
		GAF	611..762	CDD:214500	60/162 (37%)
		PDEase_I	859..1094	CDD:278654	131/236 (56%)
Pde5a	XP_006233322.1	GAF	154..311	CDD:214500	89/162 (55%)
		GAF	337..503	CDD:214500	62/170 (36%)
		PDEase_I	602..837	CDD:278654	131/236 (56%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166347767
Domainoid	1	1.000	109	1.000	Domainoid score	I6229
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H842
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	1	1.000	-	-		FOG0002593
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100960
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X5988
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.610