Protein Alignment Pde11 and LOC1277681

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_061512224.1
• Gene: LOC1277681 / 1277681
• VectorBaseID: AGAMI1_008629
• Length: 837
• Species: Anopheles gambiae
• Alignment Length: 865
• Identity: 242/865 - (27%)
• Similarity: 386/865 - (44%)
• Gaps: 166/865 - (19%)

  Fly   349 VGSSSLGSTGGASGAGG----------APSL-----------GGS--GG-----AGNGHQYPYYH 385
            ||....|..||.||.||          :|.:           |||  ||     ||......|..
Mosquito    15 VGGGGGGGGGGGSGGGGTTESNCATPTSPGMTRQDAVVVHGDGGSIDGGDPAPTAGPPSMAGYEP 79

  Fly   386 CHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGS--LFLVQGR 448
            |         :.|..|:    :|:.:....|.||::       ..:::.|.|...|  :|||...
Mosquito    80 C---------DPLIILN----LFQSLSATTNSLELQ-------MKINLHLKALTRSPYVFLVPIL 124

  Fly   449 CNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNC 513
            .:..:||.:.:         ...|.|.|.:..:.   .|........:|.|..|.|..:|  |:.
Mosquito   125 HSSEEGLIQVI---------NDNVLEKEIRFSIN---STHFRSGSQHNGYPFVIDDLNKD--FSE 175

  Fly   514 EIDSLTGYRTKALLCMPIKDSSGDVIGVAQV------------INKMNGECFSEI---------- 556
            .|:.:.|.:...|    |.|..|..:...|.            :|::|...|.:.
Mosquito   176 VIEMVVGNKHNTL----IYDILGPKVSKLQTQTSTTSASSTSSLNELNYAAFQQQAFQQQGQNGA 236

  Fly   557 -------------DEKVFSSYLQF---------CGIGLRNAQLYEKSQLEIKRNQVLLDLARMIF 599
                         |....|.| ||         .|..:...:|||:.::. .:.|.||.:||.:.
Mosquito   237 TQQQIALFVCIAGDSSSRSRY-QFYIDDTFRYVLGHLVTAFELYEEKRVR-DQCQNLLQVARRLL 299

  Fly   600 EEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESR 664
            .:...:..::..::|..:.|...:|..:.|:.:......|:|||  .|:.|:          |.|
Mosquito   300 GKIGDLGQLLRGVMTEAKELAAAERCSLFLLDKHTGELVSKVFD--GNEASK----------EIR 352

  Fly   665 FPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINK 729
            .....||.|:||.||:.:|:.|||:...|...|||::.||.|:|||..|.:..| :|||.||.||
Mosquito   353 IESGKGIAGYVAQTGKLLNIRNAYQHPLFYKGVDESTGFKTRNILCFPICDEEG-VIGVAQLCNK 416

  Fly   730 FNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEA-HRLRR 793
            .|...|.|.||....||:::||:.|.:..::::...|.|:..::.|:|.||......|. |.|..
Mosquito   417 LNGFHFDKCDEEVATAFSVYCGISIMHALVHKQVQKAEARYKLSQELLLYHMKVPDTEVNHALEA 481

  Fly   794 LRVPSAVHFRLH------DFKFDDIHFEDDDTL--KACLRMFLDLDFVERFHIDYEVLCRWLLSV 850
            ::.|......|:      ||...|:   .|..|  :..:|||.||:||..|.|....|.|::|.|
Mosquito   482 VKEPDREQDELYRTFPRFDFCPRDV---KDHALSVQLAMRMFYDLNFVGSFKIHEYKLARFVLLV 543

  Fly   851 KKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWK--IFGEIECLALIIGCLCHDLDHRGTNNSFQI 913
            :|.||:..||||.|||:||...::::...:..:  |..:::..:.:|...||||||||.:||:|.
Mosquito   544 QKGYRDTPYHNWWHAFSVAHFAYSLMMNLRLIERGIITKMQGFSFLIAAFCHDLDHRGISNSYQT 608

  Fly   914 KASSPLAQLYST--STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYF 976
            :.|||||:|||:  |..|.||..|.:.|||...::||..||:.::...|..|.:.||:||||.:|
Mosquito   609 QTSSPLARLYSSEGSVNERHHLSQAICILNDSSSKILDGLSTTEFKECIDYLRELILATDLANHF 673

  Fly   977 -------KKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFF 1034
                   |.|..:|...|.          :.||.::.:|.|||:...|.|:..:.||.||.:|||
Mosquito   674 RILPRLKKLRAEYLTEGSN----------QRLLLSLMITCCDLNDQIKSWKTVQHVAHLVYAEFF 728

  Fly  1035 EQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGH 1099
            .:||:||| :.:.|..:|:|:|.. :||:|:.|:.::..|.:|....:..:....::.:..||..
Mosquito   729 AEGDLEKQ-MGLRPNAMMDRKKAC-IPMLQIEFLTTVIRPTFEILVQIFPETGSFLDTIDSNREQ 791

  Fly  1100 WIDLADVVKTKTSQDQEPEE 1119
            |    :.|:.:.:|.....|
Mosquito   792 W----ERVRNRAAQQGNGSE 807

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	37/207 (18%)
		GAF	611..762	CDD:214500	52/150 (35%)
		PDEase_I	859..1093	CDD:459723	85/244 (35%)
LOC1277681	XP_061512224.1	None