DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde6c

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	NP_291092.1	Gene:	Pde6c / 110855	MGIID:	105956	Length:	861	Species:	Mus musculus

Alignment Length:	837	Identity:	266/837 - (31%)
Similarity:	431/837 - (51%)	Gaps:	101/837 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   393 LSRNELKQLDEKELIFELVKDICNEL-EVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLK 456
            ||..|:.|::|..:..||::.:.:|. ....:.|:.||.::.||.||..|:|    .|...:|:.
Mouse    48 LSLPEMTQVEESAVCLELLQCMQDEAGSAEQMAHRALQRLAQLLQADCCSMF----SCRARNGIP 108

  Fly   457 KCLVSKLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLT 519
            : :.|:|.:|.|.|..|:  :....||......||.|.||...:.:|:.|..::..|:..:|..|
Mouse   109 E-VASRLLNVTPTSKFEDNLVAPDREVVFPLDIGIVGWVAHVKKALNVSDVKKNSHFSDFMDKQT 172

  Fly   520 GYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLR---NAQLYEKS 581
            ||.|:.||.:||. :..:|:.|...:||::...||:.||:|||.||.|..:.||   .:.||
Mouse   173 GYVTRNLLAVPIV-AGKEVLAVVMAVNKISAPEFSKQDEEVFSKYLSFVAVALRLQHTSYLY--- 233

  Fly   582 QLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVH--------------- 631
            .:|.:|:|:|:..|..:|||.:.:|....:.|..:::.:.|.|..|.|:.
Mouse   234 SVESRRSQILMWSANKVFEELTDVERQFHKALYTIRTYLNCDRYSIGLLDMTKEKEFYDEWPIKL 298

  Fly   632 ---EADKGS---------FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNV 684
               |..||.         |.::.|:..:  .:||.....||....:.:..|:..:||..|...|:
Mouse   299 GEVEPYKGPKTPDGREIIFYKIIDYILH--GKEEINVIPSPPADHWTLVSGLPTYVAENGFICNM 361

  Fly   685 PNAYEDDRF---DASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAF 746
            .||..|:.|   ...|||.. :..:::|.:.|.|....|:||....|:.:...|.::||:..|..
Mouse   362 LNAPADEYFTFQKGPVDETG-WVIKNVLSLPIVNKKEDIVGVATFYNRKDGKPFDEHDEHITETL 425

  Fly   747 AIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLR---------------- 795
            ..|.|..:.||..||:.....:::.:..|::.....||.||...:.:.:
Mouse   426 TQFLGWSLLNTDTYERVNKLESRKDIAQEMVMNLTKATPDEISSILKFKEKLNVEVIEECEERQL 490

  Fly   796 -------VPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKN 853
                   :|......|::|.|.|....:.:.:|..||:||:::.||:|.:..|||.||:.:|:|.
Mouse   491 LAILKEDLPDPRTADLYEFCFSDFPITEHELVKCGLRLFLEINVVEKFKVPVEVLTRWMYTVRKG 555

  Fly   854 YRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSP 918
            ||.||||||||.|||.|.||.:|.|.:..|.:.::|..|::....|||:|||||||.:|:|::||
Mouse   556 YRPVTYHNWRHGFNVGQTMFTLLMTGRLKKYYTDLEAFAMLAAAFCHDIDHRGTNNLYQMKSTSP 620

  Fly   919 LAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFL 983
            ||:|:.||.:|.||.:....:|......|..||:...:..||.:.|.||::||||:|||||..|.
Mouse   621 LARLHGTSILERHHLEYSKTLLQDESLNIFQNLNKRQFETVIHLFEVAIIATDLALYFKKRTMFQ 685

  Fly   984 ESV--------SQPTSYWVAEEP--RALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGD 1038
            :.|        .:.|..:|..:|  :.::.||.||.|||||||||||::.:||.||::||:||||
Mouse   686 KIVDTCEQMQSEEETIKYVTSDPTKKEVIMAMMMTACDLSAITKPWEVQSQVALLVANEFWEQGD 750

  Fly  1039 MEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDL 1103
            :|:..|...||.:|:|.|:||||.:||.|||.:|..:|:.|:....::.|::.|:::||..|..|
Mouse   751 LERTVLQQQPIPMMDRSKKDELPKLQVGFIDFVCTFVYKEFSRFHGEITPMLNGLQNNRVEWKSL 815

  Fly  1104 ADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVD---SPSEKAS 1157
            |:..:.|....:|...:|:::                 ||:.:.|.|   |..:|.|
Mouse   816 AEEYEAKVKVTEEEAGKQEEE-----------------ASDGKAATDLGGSAEDKKS 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	54/166 (33%)
		GAF	611..762	CDD:214500	42/180 (23%)
		PDEase_I	859..1094	CDD:278654	108/244 (44%)
Pde6c	NP_291092.1	GAF	81..232	CDD:214500	52/156 (33%)
		GAF	256..443	CDD:214500	44/189 (23%)
		PDEase_I	561..806	CDD:278654	108/244 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	826..861		9/47 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844383
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750