DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and Pde4c

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_011240550.1	Gene:	Pde4c / 110385	MGIID:	99556	Length:	745	Species:	Mus musculus

Alignment Length:	476	Identity:	119/476 - (25%)
Similarity:	209/476 - (43%)	Gaps:	79/476 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   714 KNSLGQIIGVIQLINKF-----NELDF---TKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQ 770
            :.|:|::..     |||     .||.:   |....|.|..:       |..|.:.::|.|.:.:.
Mouse   287 RRSVGEMAS-----NKFKRMLNRELSYLSETSRSGNQVSEY-------ISQTFLDQQAEVELPQP 339

  Fly   771 SVTLEVLSYHASATMDEAHRLRRLRVPSAV--HFRLHDFKFDDIHFEDDDTLK------------ 821
            ....:.   ...|.:.|..|.....:|:|.  .|.:...:.:.:..|.:||.|
Mouse   340 PTEDDP---WPMAQITELRRSSHTSLPTAAIPRFGVQTDQEEQLAKELEDTNKWGLDVFKVAELS 401

  Fly   822 -------ACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTT 878
                   ....:|.:.|.::.|.|..:.|..:||:::.:|. :|.|||..||.:|.|....:|.|
Mouse   402 GNRPLTAVIFSVFQERDLLKTFQIPADTLLAYLLTLEGHYHSDVAYHNSMHAADVVQSAHVLLGT 466

  Fly   879 TQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNS 942
            .....:|.::|.||.|..|..||:||.|.:|.|.|..:|.||.:|: :|.:|:||......:|..
Mouse   467 PALEAVFTDLEVLAAIFACAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQG 531

  Fly   943 PGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPR 999
            ....|..|||:.....:.|::.|.:|:||::.:.......  :....:.||..|      ::..:
Mouse   532 ENCDIFRNLSTKQRLSLRRMVIDMVLATDMSKHMSLLADLKTMVETKKVTSLGVLLLDNYSDRIQ 596

  Fly  1000 ALLRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPM 1062
            .|   .|:..| |||...||..:.::..:.:.:|||:|||.|::. |:|:|   |..:....:..
Mouse   597 VL---QSLVHCADLSNPAKPLPLYRQWTERIMAEFFQQGDRERESGLDISP---MCDKHTASMEK 655

  Fly  1063 MQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDL-----------ADVVKTKTSQDQ 1115
            .||.|||.|..|::|.:|.| ....:.|::.:.||| .|...           :|..|.:.:.::
Mouse   656 SQVGFIDYIAQPLWETWADLVHPDAQELLDTLEDNR-EWYQSRIPCSPPHTMGSDRFKFELTLEE 719

  Fly  1116 EPEEEQQQQNVISNGDCKAMS 1136
            ..|||:::    ..|.|.|::
Mouse   720 AEEEEEEE----DEGQCTALN 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	12/55 (22%)
		PDEase_I	859..1094	CDD:278654	74/246 (30%)
Pde4c	XP_011240550.1	PDE4_UCR	213..329	CDD:375549	12/53 (23%)
Pde4c	XP_011240550.1	PDEase_I	447..688	CDD:365964	74/246 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167844385
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.750