Protein Alignment Pde11 and PDE10A

DIOPT Version :9

• Sequence 1: NP_001286044.1
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: NP_001372008.1
• Gene: PDE10A / 10846
• HGNCID: 8772
• Length: 1055
• Species: Homo sapiens
• Alignment Length: 1141
• Identity: 318/1141 - (27%)
• Similarity: 494/1141 - (43%)
• Gaps: 245/1141 - (21%)

  Fly    72 EEPATTPLQFQPTGRMNTEQGGTGYG--------GYGSSEHSLLIATRHAGVPLPLAQHQPLPAH 128
            :||...|.:.:|..|::...||:..|        |.|.:|        .|..|.|
Human    21 DEPGCGPGKLRPEPRLSAAGGGSAAGPGPAPEWPGRGRAE--------RAAPPRP---------- 67

  Fly   129 YQPLNHSGAAPPSSSNGS-SSSGGGVQTSATPQQQQQYQVQQPYQYQYQHHYHHQANSPQHHRPY 192
              ||:.:|...|:...|: |:.|||....|         .:.|....:....  .::||.....:
Human    68 --PLSSAGRPSPAGGPGALSARGGGCGWVA---------ARAPLALAFSSRV--PSSSPSFFYFW 119

  Fly   193 DPEHARMEAWLDENQEFVQDYFIRKATRQTVDAWLVSHATSA------------GNDVVSSTSPT 245
            .|......::|..:..|  ...:|...|:...|     |.:|            |.:....:.||
Human   120 PPPPPPPPSFLPSSSAF--HLPVRLPGREGAAA-----AAAAGGGGDAGGGGGGGQEAAPLSVPT 177

  Fly   246 HANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNGSVGGSCSNL 310
                 :||.|||.|:....|::......:|.||..........|..|.:|
Human   178 -----SSSHRGGGGSGGGRRRLFLSPALQGLLLPARAGPRPPPPPRLPLG--------------- 222

  Fly   311 QNVGGVVAGQYQYNHQQHHHNHAHLHHSQHSHYQAGGAVGSSSLGSTGGASGAGG---------- 365
                                             ||....||.  |..|...|.||
Human   223 ---------------------------------QAARRAGSP--GFPGAGPGGGGQTPRRPQGAS 252

  Fly   366 ------APSLGGS----GGAGNGHQY------------------PYYHCHQRPQ----------- 391
                  |..|.||    |.:.|...:                  .|...|  ||
Human   253 FALAAAAALLFGSDMEDGPSNNASCFRRLTECFLSPSLTDEKVKAYLSLH--PQVLDEFVSESVS 315

  Fly   392 ------RLSRNELKQLDE---KE-----------LIFELVKDICNELEV----RTLCHKILQNVS 432
                  .|.|...|..||   ||           :::||...|...|:.    :.|.:::...:.
Human   316 AETVEKWLKRKNNKSEDESAPKEVSRYQDTNMQGVVYELNSYIEQRLDTGGDNQLLLYELSSIIK 380

  Fly   433 ILLNADRGSLFLVQGRCNG------PDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAG 491
            |...||..:|:.: |.||.      |.|:|:. ..:|....|              :..||.::.
Human   381 IATKADGFALYFL-GECNNSLCIFTPPGIKEG-KPRLIPAGP--------------ITQGTTVSA 429

  Fly   492 HVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEI 556
            :||:|.:.:.:.|...||||.......:|.|.:::||:||..:.||:||:.::......|.|...
Human   430 YVAKSRKTLLVEDILGDERFPRGTGLESGTRIQSVLCLPIVTAIGDLIGILELYRHWGKEAFCLS 494

  Fly   557 DEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQ 621
            .::|.::.|.:..:.:...|:......:.:.|..|||:::..|:....|:.::..|:.:.::|:.
Human   495 HQEVATANLAWASVAIHQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVN 559

  Fly   622 CQRVQILLVHEADKGSFSRVFDFEANDLSEEE----ATSRTSPYESRFPINIGITGHVATTGETV 682
            ..|..:..|...:|..:|.:|     |:.||:    ...:|.  |.||.|..||.|.||.|||.:
Human   560 ADRCALFQVDHKNKELYSDLF-----DIGEEKEGKPVFKKTK--EIRFSIEKGIAGQVARTGEVL 617

  Fly   683 NVPNAYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFA 747
            |:|:||.|.||:..||..:.:..|:||||.|. |.|.:|||:|::||.:...|:|.|||..:.||
Human   618 NIPDAYADPRFNREVDLYTGYTTRNILCMPIV-SRGSVIGVVQMVNKISGSAFSKTDENNFKMFA 681

  Fly   748 IFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDI 812
            :||.:.:|..:||.:...:.....||:|.||||:..|.:|...|.:..:|..:...:..|.||..
Human   682 VFCALALHCANMYHRIRHSECIYRVTMEKLSYHSICTSEEWQGLMQFTLPVRLCKEIELFHFDIG 746

  Fly   813 HFEDDDTLKACLRMFLDLDFVERFH-------IDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQ 870
            .||:         |:..: ||...|       .:.|.|||:::|||||||.|.||||:||..||.
Human   747 PFEN---------MWPGI-FVYMVHRSCGTSCFELEKLCRFIMSVKKNYRRVPYHNWKHAVTVAH 801

  Fly   871 MMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQ 935
            .|:|||....  .:|.::|...|:|.||||||||||.:||:..|...|||.||||||||.|||.|
Human   802 CMYAILQNNH--TLFTDLERKGLLIACLCHDLDHRGFSNSYLQKFDHPLAALYSTSTMEQHHFSQ 864

  Fly   936 CLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP-R 999
            .:.||...|:.|.:.|||.:|.:|:.::..||::||||:||..|.. ||.:.|..|..:..:. |
Human   865 TVSILQLEGHNIFSTLSSSEYEQVLEIIRKAIIATDLALYFGNRKQ-LEEMYQTGSLNLNNQSHR 928

  Fly  1000 ALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQ 1064
            ..:..:.||.|||.::||.|.:.|..|:.:.:||:.:|| |.::|.|.||.:|:|:|:||:|..|
Human   929 DRVIGLMMTACDLCSVTKLWPVTKLTANDIYAEFWAEGD-EMKKLGIQPIPMMDRDKKDEVPQGQ 992

  Fly  1065 VNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHW 1100
            :.|.:::.:|.|.....:....|||::..|||...|
Human   993 LGFYNAVAIPCYTTLTQILPPTEPLLKACRDNLSQW 1028

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	38/171 (22%)
		GAF	611..762	CDD:214500	58/154 (38%)
		PDEase_I	859..1094	CDD:278654	99/235 (42%)
PDE10A	NP_001372008.1	GAF	367..510	CDD:396252	37/158 (23%)
		GAF	543..698	CDD:214500	59/162 (36%)
		PDEase_I	790..1022	CDD:395177	99/235 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3689
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4111
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4714
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.800