DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde1ca

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_021326050.1	Gene:	pde1ca / 101883995	ZFINID:	ZDB-GENE-111215-4	Length:	777	Species:	Danio rerio

Alignment Length:	712	Identity:	164/712 - (23%)
Similarity:	276/712 - (38%)	Gaps:	145/712 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   681 TVNVPNAYED------------DRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQ-------- 725
            ||:.|:|.|.            :|.:|||             :.:|.:|.....|::
Zfish    90 TVDSPDAMEKTAIRLRCLVKQLERGEASV-------------VDLKKNLEYAASVLESVYIEETR 141

  Fly   726 -LINKFNELDFTKNDENFVE-----AFAIFCGMGIHNTHMYEK----AIVAMAKQSVTLEVLSYH 780
             |::..:||...::|....|     |......||:......||    :||...:..:.:|.:...
Zfish   142 RLVDTEDELSDIQSDSVPSEVRDWLASTFTRQMGLMLRRSEEKPRFRSIVHAVQAGIFVERMYRR 206

  Fly   781 ASATMDEAHRLRRLRVPSAVHFRLH--DFKFDDIHFED---DDTLKACLRMFLDL----DFVERF 836
            .|..:..::      .||.:....|  .:.||.....|   |.:||.   :|.:|    |.:.||
Zfish   207 TSNMVGLSY------PPSVITALKHVDTWSFDVFTLNDASGDHSLKF---IFYELLTRYDLINRF 262

  Fly   837 HIDYEVLCRWLLSVKKNY---RNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCL 898
            .|....|..::.:::..|   || .|||..||.:|.|.:..:|..|.......|:|..|::....
Zfish   263 KIPVSALVSFVEALEVGYGKHRN-PYHNLIHAADVTQTVHYLLLKTGMVHWLTELEIFAMLFAAA 326

  Fly   899 CHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNSPGN-QILANLSSDDYCRVIR 961
            .||.:|.||.|:|.|:..|..|.||: .:..|:||......:|..... .||.|||.||:..:..
Zfish   327 VHDYEHTGTTNNFHIQTRSDTAILYNDRAVQENHHVSAAYRLLQEDDEMNILYNLSKDDWRELRT 391

  Fly   962 VLEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVA 1026
            ::.:.:|:||::.:|::.......:.||..   .::|:||  ::.:...|:|...|.|.:..|..
Zfish   392 LVVEMVLATDMSCHFQQIKAMKNFLQQPEG---IDKPKAL--SLLLHTADISHPAKNWNMHYRWT 451

  Fly  1027 DLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLE---- 1087
            ..:..|||.|||.| .||.: |...:...|...:...|:.|||.|..|   .|..|:|.:|
Zfish   452 TSLLEEFFRQGDKE-AELGL-PFSPLCDRKSTMVAQSQIGFIDFIVEP---TFTVLTDMIEKIMT 511

  Fly  1088 PLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSP 1152
            ||:|....        |.:...:.|.......:.::.:|.|.|            ||...:|:|
Zfish   512 PLIEEASP--------AGLAGFRRSSLNNIPSDGKRSSVRSTG------------SEGGTSVNS- 555

  Fly  1153 SEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDNDVDADADDVDEQA----AEENGHDAEV 1213
                |:|..:.....|..|:::.........|.          |.|::|:|    .|||....:.
Zfish   556 ----SINAVDFKTFKSTWNEEVHKNREKWKAQA----------AKDLEEKAKQEEMEENEKKKDT 606

  Fly  1214 DEASCRSNSTCSSSTASSCLSTPPPTGEDDSTPVSPLKTLQAKLVAANLNALQRQTSNQAQTQKQ 1278
            |..|...|:.......:...:..|...::|:.|....||.|.       ::.:.:..|:..|::|
Zfish   607 DTQSSDDNTKTEDKINTDSNAKSPDKQKEDTRPEKDSKTDQE-------DSGKAKVDNKEPTEQQ 664

  Fly  1279 -RCKSCDHSRSGLQVRKTSSLRGAQELDLDSKTRNGTHAALCKSTPVINNHSHHHNHSHSHN 1339
             |.|..:....|:...:|.|  ..:|.:..|.|               :|....||.|...|
Zfish   665 PREKEGNKDPGGMNGAQTPS--DGKEPETSSDT---------------DNSQRVHNGSEELN 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	20/106 (19%)
		PDEase_I	859..1094	CDD:278654	73/240 (30%)
pde1ca	XP_021326050.1	PDEase_I_N	146..202	CDD:312112	11/55 (20%)
		PDEase_I	287..513	CDD:306695	70/235 (30%)
		COG3942	584..>760	CDD:332523	32/160 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.010