DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde4a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_031755243.1	Gene:	pde4a / 100488846	XenbaseID:	XB-GENE-5789473	Length:	744	Species:	Xenopus tropicalis

Alignment Length:	813	Identity:	167/813 - (20%)
Similarity:	308/813 - (37%)	Gaps:	194/813 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   474 EMEQQDEV-----------RVAWGTGIAGHVAESGEPVNIPDAYQDERFNCE---------IDSL 518
            :||:.|.:           |::|.:...|..:.|       .|...:||:.|         |||
Frog    57 QMERADAMDTSDRPGLRKSRMSWPSSFHGTTSNS-------HASHKQRFDVENGPSPGRSPIDS- 113

  Fly   519 TGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQL 583
                         :.|.|.|:..:          |.:...:  .|:|      .|:...|:.|..
Frog   114 -------------QASPGLVLHPS----------FPQSQRR--ESFL------YRSDSDYDMSPK 147

  Fly   584 EIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGSFSRVFDFEAND 648
            .:.||..:...|                   |.:.||.....|:|    |...|....|...||
Frog   148 TMSRNSSVTSEA-------------------HAEDLIVTPFAQVL----ASLRSVRNNFTILAN- 188

  Fly   649 LSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYED-DRFDASVDENSCFK-HRSILCM 711
                    .|:|...|.|:....|...||..|......|.|. :..|..:|:....: :||:..|
Frog   189 --------VTTPTNKRSPVMPQQTVCKATLSEETYQQLAKETLEELDWCLDQLETMQTYRSVSEM 245

  Fly   712 A-----------------IKNSLGQIIGVIQ--LINKFNELDF---TKNDENFVEAFAIFCGMG- 753
            |                 :..|..|:...|.  .::|.||:|.   |:.:....:.....|.:.
Frog   246 ASNKFKRMLNRELTHLSEMSRSGNQVSEYISNTFLDKQNEVDIPSPTQKEREKKKKQQPMCQISG 310

  Fly   754 ----IHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHF 814
                :|::.:...||.....::...|.|.       .|...|.:        :.|:.|:..:  :
Frog   311 VKKLMHSSSLTNSAIPRFGVKTDQEESLG-------KELDNLNK--------WGLNIFRVAE--Y 358

  Fly   815 EDDDTLKACL-RMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILT 877
            .::..|...: .:|.:.:.::.|.|..:.|..::::::.:|. :|.|||..||.:|.|....:|:
Frog   359 SNNRPLSCTMYTVFQERELLKTFKIPVDTLMTYMMTLEDHYHADVAYHNSLHAADVTQSTHVLLS 423

  Fly   878 TTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILN 941
            |.....:|.::|.||.:.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|.
Frog   424 TPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQ 488

  Fly   942 SPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWVA-----EEPR 999
            .....|..||:......:.:::.|.:|:||::.:.......  :....:.||..|.     .:..
Frog   489 EENCDIFQNLTKRQRQTMRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRI 553

  Fly  1000 ALLRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPIDIMNREKEDELPM 1062
            .:||  :|..| |||..|||.|:.::..|.:..|||.|||.|::. :.|:|   |..:....:..
Frog   554 QVLR--NMVHCADLSNPTKPLELYRQWTDRILEEFFRQGDKERERGMEISP---MCDKHTASVEK 613

  Fly  1063 MQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQNV 1126
            .||.|||.|..|::|.:|.| ....:.:::.:.|||..:..:.....:....|.:.:||.
Frog   614 SQVGFIDYIVHPLWETWADLVHPDAQDILDTLEDNRDWYQGMIPQSPSPPPDDPDKDEEA----- 673

  Fly  1127 ISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDND 1191
                 |       :...:.|:.::..:|          ::..:.|..|           .::|.:
Frog   674 -----C-------IEKFQFELTLEEEAE----------DSDKDRNSGI-----------EEEDGN 705

  Fly  1192 VDADADDVDEQAAE-ENGHDAEVDEASCRSNST 1223
            ...:|.::.|...| ...|:.:.::....|::|
Frog   706 CLHEAPEIQEPEEEFMTMHEGQAEQTDVYSDNT 738

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	22/127 (17%)
		GAF	611..762	CDD:214500	36/179 (20%)
		PDEase_I	859..1094	CDD:278654	72/245 (29%)
pde4a	XP_031755243.1	PDE4_UCR	166..281	CDD:407935	26/127 (20%)
pde4a	XP_031755243.1	PDEase_I	405..646	CDD:395177	72/245 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010