Protein Alignment Pde11 and pde6b

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_012808736.2
• Gene: pde6b / 100487945
• XenbaseID: XB-GENE-961019
• Length: 859
• Species: Xenopus tropicalis
• Alignment Length: 839
• Identity: 263/839 - (31%)
• Similarity: 436/839 - (51%)
• Gaps: 105/839 - (12%)

  Fly   397 ELKQLDEKELIFELVKDICNELEVRTLCHKILQNVSILLNADRGSLFLVQGRCNGPDGLKKCLVS 461
            ||.|::|.|::||||.|:...:.:..:..|.|:.:|.|::|||.|||:.:.|...|:     |.:
 Frog    55 ELVQVEESEILFELVNDMQESINMEKVVFKTLRRISFLIHADRCSLFMYRQRNGTPE-----LAT 114

  Fly   462 KLFDVCPRSTVEE--MEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTK 524
            :||:|...|.:||  :....|:......||.||||.:.:.:|:.|..:...::...|.||.|.||
 Frog   115 RLFNVKSNSKLEECLVPPDSEIVYPLDIGIVGHVAHTKKTINVKDVSECTVYSKFADELTDYETK 179

  Fly   525 ALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQL---EIK 586
            .:|..||.:.. ||:.|...:||::|..|:..||:||..||.|..:   |.::|..|.|   |.:
 Frog   180 NILATPILNGK-DVVAVIMAVNKLDGPFFTNYDEEVFLKYLNFASL---NLKIYHLSYLHNCETR 240

  Fly   587 RNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQI-LLVHEADKGSFS----------- 639
            |.||||..|..:|||.:.||....:....:::.:.|.|..: ||....:|..|.
 Frog   241 RGQVLLWSANKVFEELTDIERQFHKAFYTVRAYLNCDRYSVGLLDMTKEKEFFDVWPVLMGEVPP 305

  Fly   640 ---------------RVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYE 689
                           :|.|:..:  .:|:.....:|....:.:..|:..:||.:|...|:.||..
 Frog   306 YTGPRTPDGREIVFYKVIDYILH--GKEDIKVIPNPPADHWALVSGLPTYVAESGFICNIMNAGA 368

  Fly   690 DDRFDASVD--ENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGM 752
            |:.|....:  :.|.:..:::|.|.|.|...:|:||....|:.:...|.:.||..:|:...|.|.
 Frog   369 DEMFKFQKEPLDESGWVVKNVLSMPIVNKKEEIVGVATFYNRKDGKPFDEQDETLMESLTQFLGW 433

  Fly   753 GIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDE-----------------------AHRLRRL 794
            .:.||..::|......::.:..:::.||.....||                       |..|:::
 Frog   434 SVLNTDTHDKMNKLENRKDIAQDMVMYHVKCDKDEIQDILPTREKLGKEVTECEEDEIAKTLKQV 498

  Fly   795 RVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTY 859
             :|....|.:::|:|.|....:.|.:|..::|:.:|..|::|.:..|.|.|::.::||.||.|||
 Frog   499 -LPGPTKFEIYEFRFSDFDCTEIDLVKCGIQMYYELGVVKKFQVPPEALVRFMYAMKKGYRRVTY 562

  Fly   860 HNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS 924
            |||||.|||||.||.:|.|.:..:.:.::|.:|::....|||:|||||||.:|:|:..|||:|:.
 Frog   563 HNWRHGFNVAQTMFTLLMTGKLKRYYTDLEAMAMVTAGFCHDIDHRGTNNLYQMKSQHPLAKLHG 627

  Fly   925 TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQP 989
            :|.:|.||.:....:|......|..||:...:..||.:::.||::||||:|||||..|.:.|.|.
 Frog   628 SSILERHHLEFGKFLLADESMNIFQNLNRRQHEHVIHLMDIAIIATDLALYFKKRTMFQKIVDQS 692

  Fly   990 TSY-----W-----VAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQEL 1044
            .:|     |     :....:.::.||.||.|||||||||||::.:||.||::||:||||:|:..|
 Frog   693 KTYEDEQKWTEYLSLETTRKEIVMAMMMTACDLSAITKPWEVQSKVALLVAAEFWEQGDLERTVL 757

  Fly  1045 NITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKT 1109
            ...||.:|:|.|..|||.:|..|||.:|..:|:.||...::::|:::|:.:||..|..|||..:.
 Frog   758 QQQPIPMMDRNKSAELPKLQCGFIDFVCTFVYKEFARFHEEIQPMLDGLLNNRKEWKALADEYEA 822

  Fly  1110 KTSQDQEPEEEQQQQNVISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSS 1168
            |.   :..|||::::                   |.|:|    :.||:..|:|.|.:|:
 Frog   823 KV---KTVEEEKKKR-------------------EEELA----ARKAAAAGANAAKSST 855

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	53/163 (33%)
		GAF	611..762	CDD:214500	36/179 (20%)
		PDEase_I	859..1093	CDD:459723	103/243 (42%)
pde6b	XP_012808736.2	GAF	77..236	CDD:214500	55/167 (33%)
		GAF	258..445	CDD:214500	39/188 (21%)
		PDEase_I	562..806	CDD:459723	103/243 (42%)