DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde3b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_031756238.1	Gene:	pde3b / 100487373	XenbaseID:	XB-GENE-486086	Length:	1015	Species:	Xenopus tropicalis

Alignment Length:	542	Identity:	116/542 - (21%)
Similarity:	199/542 - (36%)	Gaps:	139/542 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   758 HMYEKAIVAMAKQSVTLEVLSYHASATMD------EAHRLRRLRVPSAVHFRLHDFKFDDIHFED 816
            |:.|||      |...|...:.:.|.|.:      :|.|...::..|.:...|         .||
Frog   517 HLKEKA------QETRLHKDTRNVSETHEPYTEPGQAGRESEMKEESPLELML---------IED 566

  Fly   817 DDTL---------------------------KACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNY 854
            .|:|                           :....:|.|....|.|.|.......:..:::..|
Frog   567 QDSLLDRLDNWNFPIFDLVERTGGKSGRILSQVSYTLFQDTGLFEIFKIPLREFQNFFRALESGY 631

  Fly   855 RNVTYHNWRHAFNVAQMMFAILT-----------------------------TTQWWKIFGE--- 887
            |::.|||..||.:|...::.:.|                             |::..|:..|
Frog   632 RDIPYHNRIHATDVLHSVWYLSTRPIPGFHEIHSDETDPDPDAEGGASQVFLTSKTCKLPDESYG 696

  Fly   888 --------IECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCL-MILNS 942
                    :|.:||.:....||.||.|..|:|.:..::|.|.||: .|.:|:||..... :.|:.
Frog   697 CLSSNIPALELMALFVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLFLSQ 761

  Fly   943 PGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPTSY---WVAEEPRALLRA 1004
            |.:..|..|....:.|...::.:|||:|||..:|.....|...|:.....   |..|..|.|:..
Frog   762 PEHNFLTYLDHVQFKRFRFLVIEAILATDLKKHFDFLAEFNAKVNDVNGIGIDWSNENDRLLVCQ 826

  Fly  1005 MSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFID 1069
            :.:.:.|::...|..|:..:..:.:.:||:|||| |:..|.: ||.........:|..:|.:||.
Frog   827 VCIKLADINGPAKTRELHLKWTEGIVNEFYEQGD-EESSLGL-PISPFMDRSAPQLAKLQESFIT 889

  Fly  1070 SICLPI---YEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQE---PEEEQQQQNVIS 1128
            .|..|:   |:|...|.              |.|::..:.|.....:|.|   .|||:.::::..
Frog   890 HIVGPLCNSYDAAGLLP--------------GRWLEEDEEVMESEDEDGEELDSEEEEMEEDINP 940

  Fly  1129 NGD--------CKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQP 1185
            ...        |:.:..    ..|...|.....|:...:.:......|:.    |.|:.|
Frog   941 KPQRRKRRRMFCRLIHH----LRENHKAWKKTIEEEEKSKAEQTKQQSDD----APAAPP----- 992

  Fly  1186 SDDDNDVDADADDVDE-QAAEE 1206
              ||..|..:||:.:| |:.||
Frog   993 --DDIQVIEEADEEEERQSGEE 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	1/3 (33%)
		PDEase_I	859..1094	CDD:278654	68/282 (24%)
pde3b	XP_031756238.1	PDEase_I	636..906	CDD:395177	67/271 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010