DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and pde10a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_031757888.1	Gene:	pde10a / 100485841	XenbaseID:	XB-GENE-1013417	Length:	799	Species:	Xenopus tropicalis

Alignment Length:	724	Identity:	240/724 - (33%)
Similarity:	391/724 - (54%)	Gaps:	43/724 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   390 PQRLSRNELKQLDEKELIFELVKDICNELEV----RTLCHKILQNVSILLNADRGSLFLVQGRCN 450
            |..:|| :.:..:.:.:::||...:...|:.    :.|.:::...:.....||..:|:.: |.||
Frog    74 PTEVSR-QYQDTNMQGVVYELNSYMEQRLDAGGDNKLLLYELSDIIKTATKADGFALYFL-GECN 136

  Fly   451 G------PDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDE 509
            .      |.|.|.       ...|.::|..:|        :||.::.|||:|...|.:.|...||
Frog   137 NTLCLFTPTGTKD-------GQTPLTSVGPVE--------YGTTVSAHVAKSRNTVLVEDILGDE 186

  Fly   510 RF--NCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGL 572
            ||  ...:||  |.|.:::||:||..:.||:||:.::........|....::|.::.|.:..:.:
Frog   187 RFPKGTGLDS--GTRIQSVLCLPIVTAIGDLIGILELYRHWGKGSFRLCHQQVATANLAWASVAI 249

  Fly   573 RNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGS 637
            ...|:......:.:.|..|||:::..|:....|:.::..|:.:.::|:...|..:..|...:|..
Frog   250 HQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKEL 314

  Fly   638 FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSC 702
            :|.:||....| ..:....:|.  |.||.|..||.|.||.|||.:|:|:||.|.||:..||..:.
Frog   315 YSDLFDIGEED-EGKPVFKKTK--EIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDVYTG 376

  Fly   703 FKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAM 767
            :..|:||||.|. ..|.:|||:|::||.:...|:|.|||..:.||:||.:.:|..:||.:...:.
Frog   377 YTTRNILCMPIV-IRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSE 440

  Fly   768 AKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDF 832
            ....||||.||||:..|.||...|....:|.::...:..:.||...|||   |...:.:::....
Frog   441 CIYRVTLEKLSYHSICTSDEWQNLMNCTLPVSLCREIELYHFDIQPFED---LWPAIYVYMIHQS 502

  Fly   833 VERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGC 897
            ..:...:.|.|||:.:|||||||.|.||||:||..|:..|:.||...|  :||.::|...|::.|
Frog   503 CGKNCFELEKLCRFTMSVKKNYRRVPYHNWKHAVTVSHCMYVILQNNQ--EIFTDLERKGLLVAC 565

  Fly   898 LCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRV 962
            |||||||||..||:..|...|||.||||||||.|||.|.:.||...|:.|.:||||::|.:|:.:
Frog   566 LCHDLDHRGYTNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSNLSSNEYEQVLEI 630

  Fly   963 LEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP-RALLRAMSMTVCDLSAITKPWEIEKRVA 1026
            :..||::||||:||..| ..||.:.|..:..:..:. |..|..:.||.|||.::||.|.:.:.:|
Frog   631 IRKAIIATDLALYFGNR-KHLEDLHQMGALNLNNQAHRDRLIGLMMTACDLCSVTKLWPVTRLIA 694

  Fly  1027 DLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVE 1091
            |.:.:||:.:|| |.:.|.|:||.:|:|:|:||:|..|:.|.:::.:|.|...:.:.....||::
Frog   695 DDIYAEFWTEGD-EMKRLGISPIPMMDRDKQDEIPQGQMGFYNAVAVPCYTTLSEIFPSTRPLLQ 758

  Fly  1092 GVRDNRGHW 1100
            ..::|...|
Frog   759 ACKENLSQW 767

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	41/173 (24%)
		GAF	611..762	CDD:214500	56/150 (37%)
		PDEase_I	859..1094	CDD:278654	98/235 (42%)
pde10a	XP_031757888.1	GAF	110..223	CDD:396252	37/130 (28%)
		GAF	282..437	CDD:214500	57/158 (36%)
		PDEase_I	529..761	CDD:395177	98/235 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I6990
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010