Protein Alignment Pde11 and pde10a

DIOPT Version :10

• Sequence 1: NP_609885.2
• Gene: Pde11 / 35107
• FlyBaseID: FBgn0085370
• Length: 1451
• Species: Drosophila melanogaster
• Sequence 2: XP_031757888.1
• Gene: pde10a / 100485841
• XenbaseID: XB-GENE-1013417
• Length: 799
• Species: Xenopus tropicalis
• Alignment Length: 724
• Identity: 240/724 - (33%)
• Similarity: 391/724 - (54%)
• Gaps: 43/724 - (5%)

  Fly   390 PQRLSRNELKQLDEKELIFELVKDICNELEV----RTLCHKILQNVSILLNADRGSLFLVQGRCN 450
            |..:|| :.:..:.:.:::||...:...|:.    :.|.:::...:.....||..:|:.: |.||
 Frog    74 PTEVSR-QYQDTNMQGVVYELNSYMEQRLDAGGDNKLLLYELSDIIKTATKADGFALYFL-GECN 136

  Fly   451 G------PDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVAESGEPVNIPDAYQDE 509
            .      |.|.|.       ...|.::|..:|        :||.::.|||:|...|.:.|...||
 Frog   137 NTLCLFTPTGTKD-------GQTPLTSVGPVE--------YGTTVSAHVAKSRNTVLVEDILGDE 186

  Fly   510 RF--NCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMNGECFSEIDEKVFSSYLQFCGIGL 572
            ||  ...:||  |.|.:::||:||..:.||:||:.::........|....::|.::.|.:..:.:
 Frog   187 RFPKGTGLDS--GTRIQSVLCLPIVTAIGDLIGILELYRHWGKGSFRLCHQQVATANLAWASVAI 249

  Fly   573 RNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQCQRVQILLVHEADKGS 637
            ...|:......:.:.|..|||:::..|:....|:.::..|:.:.::|:...|..:..|...:|..
 Frog   250 HQVQVCRGLAKQTELNDFLLDVSKTYFDNIVAIDSLLEHIMIYAKNLVNADRCALFQVDHKNKEL 314

  Fly   638 FSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDENSC 702
            :|.:||....| ..:....:|.  |.||.|..||.|.||.|||.:|:|:||.|.||:..||..:.
 Frog   315 YSDLFDIGEED-EGKPVFKKTK--EIRFSIEKGIAGQVARTGEVLNIPDAYADPRFNREVDVYTG 376

  Fly   703 FKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAM 767
            :..|:||||.|. ..|.:|||:|::||.:...|:|.|||..:.||:||.:.:|..:||.:...:.
 Frog   377 YTTRNILCMPIV-IRGSVIGVVQMVNKLSGSAFSKTDENNFKMFAVFCALALHCANMYHRIRHSE 440

  Fly   768 AKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDF 832
            ....||||.||||:..|.||...|....:|.::...:..:.||...|||   |...:.:::....
 Frog   441 CIYRVTLEKLSYHSICTSDEWQNLMNCTLPVSLCREIELYHFDIQPFED---LWPAIYVYMIHQS 502

  Fly   833 VERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGC 897
            ..:...:.|.|||:.:|||||||.|.||||:||..|:..|:.||...|  :||.::|...|::.|
 Frog   503 CGKNCFELEKLCRFTMSVKKNYRRVPYHNWKHAVTVSHCMYVILQNNQ--EIFTDLERKGLLVAC 565

  Fly   898 LCHDLDHRGTNNSFQIKASSPLAQLYSTSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRV 962
            |||||||||..||:..|...|||.||||||||.|||.|.:.||...|:.|.:||||::|.:|:.:
 Frog   566 LCHDLDHRGYTNSYLQKFDHPLAALYSTSTMEQHHFSQTVSILQLEGHNIFSNLSSNEYEQVLEI 630

  Fly   963 LEDAILSTDLAVYFKKRGPFLESVSQPTSYWVAEEP-RALLRAMSMTVCDLSAITKPWEIEKRVA 1026
            :..||::||||:||..| ..||.:.|..:..:..:. |..|..:.||.|||.::||.|.:.:.:|
 Frog   631 IRKAIIATDLALYFGNR-KHLEDLHQMGALNLNNQAHRDRLIGLMMTACDLCSVTKLWPVTRLIA 694

  Fly  1027 DLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVE 1091
            |.:.:||:.:|| |.:.|.|:||.:|:|:|:||:|..|:.|.:::.:|.|...:.:.....||::
 Frog   695 DDIYAEFWTEGD-EMKRLGISPIPMMDRDKQDEIPQGQMGFYNAVAVPCYTTLSEIFPSTRPLLQ 758

  Fly  1092 GVRDNRGHW 1100
            ..::|...|
 Frog   759 ACKENLSQW 767

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_609885.2	GAF	420..582	CDD:214500	41/173 (24%)
		GAF	611..762	CDD:214500	56/150 (37%)
		PDEase_I	859..1093	CDD:459723	98/234 (42%)
pde10a	XP_031757888.1	GAF	<75..>264	CDD:441805	46/207 (22%)
		GAF	282..437	CDD:214500	57/158 (36%)
		PDEase_I	529..760	CDD:459723	98/234 (42%)