DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde4c

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_004911040.1	Gene:	pde4c / 100380081	XenbaseID:	XB-GENE-1002336	Length:	801	Species:	Xenopus tropicalis

Alignment Length:	770	Identity:	171/770 - (22%)
Similarity:	283/770 - (36%)	Gaps:	221/770 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   610 FRILTHMQSLIQ------------C---------QRVQILLVHEAD------------------- 634
            |.:|||:|..:.            |         |::.|..:.|.|
Frog   173 FAMLTHLQDRVSNKRSSGSNQPSACKPNLSEDAVQKLAIETLEELDWCLDQLETLQTRHSVSEMA 237

  Fly   635 KGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPNAYEDDRFDASVDE 699
            ...|.|:.:.|...|||   |||:....|.:     |:.........|.:|.....::     |:
Frog   238 SNKFKRMLNRELTHLSE---TSRSGNQVSEY-----ISSTFLDKQHEVEIPTPVSKEK-----DK 289

  Fly   700 NSCFKHRSILCMAIKNSLGQIIGVIQL----------INKF-----NELDFTKNDENFVEAFAIF 749
            .             |..:.||.||.:|          |.:|     .|:...|..||..:
Frog   290 K-------------KRPMSQISGVKKLTHSSSFSNCSIPRFGVKTEQEVPLAKEVENINK----- 336

  Fly   750 CGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSAVHFRLHDFKFDDIHF 814
            .|:.|..        ||....:..|.|:.|
Frog   337 WGLDIFK--------VAEYSGNRPLTVIMY----------------------------------- 358

  Fly   815 EDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYHNWRHAFNVAQMMFAILTT 878
                      .:|.:.|.::.|||..:....::::::.:|. :|.|||..||.:|||....:|:|
Frog   359 ----------SIFQERDLLKTFHIPVDTFITYMMTLEDHYHSDVAYHNNIHAADVAQSTHVLLST 413

  Fly   879 TQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYS-TSTMEHHHFDQCLMILNS 942
            .....:|.::|.:|.|.....||:||.|.:|.|.|..:|.||.:|: .|.:|:||......:|..
Frog   414 PALEAVFTDLEIMAAIFASAIHDVDHPGVSNQFLINTNSELALMYNDASVLENHHLAVGFKLLQE 478

  Fly   943 PGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPF--LESVSQPTSYWV------AEEPR 999
            ....|..||:......:.:::.|.:|:||::.:.......  :....:.||..|      ::..:
Frog   479 ENCDIFQNLTKKQRQTLRKMVIDMVLATDMSKHMNLLADLKTMVETKKVTSLGVLLLDNYSDRIQ 543

  Fly  1000 ALLRAMSMTVC-DLSAITKPWEIEKRVADLVSSEFFEQGDMEKQE-LNITPI-DIMNREKEDELP 1061
            .|   .:|..| |||..|||.||.::..|.:..|||.|||.|::: :.|:|: |..|...|..
Frog   544 VL---QNMVHCADLSNPTKPLEIYRQWTDRIIVEFFHQGDREREKGMEISPMCDKHNASVEKS-- 603

  Fly  1062 MMQVNFIDSICLPIYEAFATL-SDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEEQQQQN 1125
              ||.|||.|..|::|.:|.| ....:.:::.:.||| .|..  .::....|   .|.|||....
Frog   604 --QVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNR-EWYQ--SMIPQSPS---PPPEEQDPDR 660

  Fly  1126 VISNGDCKAMSDDDVAASEAEVAVDSPSEKASVNGSNVANNSSNTNKKIAVASHPTSTQPSDDDN 1190
            ..:.||          ..:.|:.::...|             |:|.::       .:..|.|::|
Frog   661 GNAAGD----------KFQFELTLEEEGE-------------SDTEQE-------DTESPIDEEN 695

  Fly  1191 -DVDADADDVDEQAAEENGHDAEVDEASCRSNSTCSSSTASSCLSTPPPTGEDDSTPVSPLKTLQ 1254
             |....|.|...||::|....:.||        .|  .|.||.|         |...:.|..||.
Frog   696 SDSKIHATDDSAQASDEAEQSSPVD--------LC--MTVSSKL---------DHLEIPPKSTLT 741

  Fly  1255 AKLVAANLNALQRQTSNQAQTQKQRCKSCDHSRSGLQVRKTSSLRGAQELDLDSK 1309
            .:....|.:.|:....   :|.:|:..|..|:......|:..:  |..|:.||.:
Frog   742 KQKKILNFDNLKLAGE---RTIQQKEVSSSHATPANSARQEGT--GQAEICLDQE 791

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	37/205 (18%)
		PDEase_I	859..1094	CDD:278654	75/247 (30%)
pde4c	XP_004911040.1	PDEase_I	394..635	CDD:278654	75/247 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920