DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde5aa

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_009305135.1	Gene:	pde5aa / 100334568	ZFINID:	ZDB-GENE-100414-2	Length:	922	Species:	Danio rerio

Alignment Length:	1045	Identity:	316/1045 - (30%)
Similarity:	499/1045 - (47%)	Gaps:	159/1045 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   117 LPLAQHQPLPAHYQPLNHSGAAPPSSSNGSSSSGGGVQTS---ATPQQQQQYQVQQ----PYQYQ 174
            :|....:.||:......:..|:....|.||.|..|..:.|   :|..::.:.:.:|    ...:.
Zfish     1 MPCLHTESLPSLQTESRYGVASSRRGSQGSRSKSGKKRKSGEKSTRVERNEIEKEQCAITSAAWF 65

  Fly   175 YQHHYHHQANSPQHHRPYDPEHARMEAWLDENQEFVQDYFIRKATRQTVDAWL---VSHATSAGN 236
            :...:...|.:.:.......|..:::||||:..:..:.||.|.:..     |:   ...|.:|..
Zfish    66 FTPLWVPGAKTQRLGFRMGKESEKVKAWLDDYSDSARSYFSRSSRN-----WMNGCAERAQAAQT 125

  Fly   237 DVVSSTSPTHANGQTSSSRGGSGATTPVRKISAHEFERGGLLKPIVNTIDGTPTFLSIGPPMDNG 301
            .:....|.|...|:...|...||   |.|          .|:.|:  |:....:.||:
Zfish   126 LITEPRSKTTVLGRRRVSHPMSG---PSR----------ALVHPV--TMQRPQSCLSV------- 168

  Fly   302 SVGGSCSNLQNVGGVVAGQYQYNHQQHH-----HNHAHLHHS-QHSHYQAGGAVGSSSLGSTGGA 360
                                   ||..|     ....|...| |..|:.      .|...|....
Zfish   169 -----------------------HQTDHPESLDQGGGHFPRSLQPIHFT------FSPCRSRSRC 204

  Fly   361 SGAGGAPSLGGSGGAGNGHQYPYYHCHQRPQRLSRNELKQLDEKELIFELVKDICNELEVRTLCH 425
            |...|:|...|....|....:        ..:|....:..|.:|.|..::::.:|...|.
Zfish   205 SSFLGSPRPAGQCRRGESCAF--------MMQLFSGLIGALQDKNLHLQVLQHLCEVTEA----- 256

  Fly   426 KILQNVSI-LLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGI 489
               |.||: :...|:     ..|:|.||              ..:|..:.:....:.:  |...|
Zfish   257 ---QRVSLSMTTVDK-----TGGKCLGP--------------VLQSDADSVHSNAQTK--WNKSI 297

  Fly   490 AGHVAESGEPVNIPDAYQDERFNCEIDSLTGYRTKALLCMPIKDSSGDVIGVAQVINKMN---GE 551
            ..:|..:|.|:.:.||::|.||..|:......|..::|.:|:.:...:||||...:||..   ..
Zfish   298 MEYVVRTGRPLTVKDAHEDPRFQVELYEGEEDRPTSVLSVPVLNHKKEVIGVVLAVNKTRTCASS 362

  Fly   552 CFSEIDEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHM 616
            .|||.||||.||::...|:.|.|.||.|.|:.|.|||||||:||:::..:..:::.|:..:...:
Zfish   363 FFSEQDEKVLSSHMMLFGLILENHQLCESSEQENKRNQVLLELAQLVSHDYPSVDAMLGELAAVI 427

  Fly   617 QSLIQCQRVQILLVHEADKGSFSRVFDFEANDLS-EEEATSRTSPYESRFPINIGITGHVATTGE 680
            ..:.:.|...:.:..::....|||:...|..::. ....:||....:.   ::.....||..:.|
Zfish   428 LPITKAQFCTVFISDDSSTRLFSRMVRIEYEEIECSVHCSSRDCDTDD---VSYIYAMHVQNSME 489

  Fly   681 TVNVPNAYEDDRFDASVDENSCFKHRSI-LCMAIKNSLG---------QIIGVIQLINKFNEL-- 733
            |:|:.|                   |.| :...|::.:|         .:|||.||:||...:
Zfish   490 TLNIVN-------------------RPISMVSPIRSLIGAPLRGKQSSNVIGVCQLVNKRMAIAE 535

  Fly   734 --DFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRV 796
              .|::.||:.:|.||::|.:|:...:..:.|.....:.:||.|||||..||:.:|.:.|....:
Zfish   536 SEAFSRADEHLLEDFAVYCALGLQKFNTQQTADKTRVRLAVTKEVLSYQISASQEEINELEEAAI 600

  Fly   797 PSAVHFRLHDFKFDDIHFEDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYR-NVTYH 860
            |||....|.||.|.|.....:...:|.:||||||:..:.|.|||:.||:|:|||:|.|| ||.||
Zfish   601 PSADTLSLLDFGFSDFDMSQNAMTQAVVRMFLDLNLPQEFKIDYKALCQWVLSVQKCYRSNVVYH 665

  Fly   861 NWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYST 925
            ||.||...||.|||:|.|.:.......:|.|||:|..|.|||||||.|||:..:::.||||||..
Zfish   666 NWSHALRTAQCMFAMLQTKELKSNLSSLEVLALMIASLSHDLDHRGVNNSYIQRSNQPLAQLYGQ 730

  Fly   926 STMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGPFLESVSQPT 990
            |::||||:|.||:|||:||:|||::||.::|...::::|..||:||||::|:||..|.:.....:
Zfish   731 SSLEHHHYDMCLLILNNPGSQILSSLSVNEYMACLQMIEKNILATDLAIFFEKRTKFFKLAENNS 795

  Fly   991 SYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNRE 1055
            ..|..|..|.|||:|.||..|:.||||||.::||:|:||::||:.|||.||:||||.|||:|:||
Zfish   796 CLWKDEGHRELLRSMLMTASDICAITKPWPVQKRIAELVATEFYAQGDREKRELNIQPIDVMDRE 860

  Fly  1056 KEDELPMMQVNFIDSICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADVVKTKTSQDQEPEEE 1120
            ....||.|||::||.||.|:|||.|.:.:...||.||...||.||.::.|        |::.:..
Zfish   861 NASRLPQMQVDYIDGICSPLYEALAFICESCSPLKEGCSKNRKHWQEMVD--------DRKEDNI 917

  Fly  1121 QQQQN 1125
            ::|:|
Zfish   918 KEQEN 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	44/165 (27%)
		GAF	611..762	CDD:214500	32/165 (19%)
		PDEase_I	859..1094	CDD:278654	121/234 (52%)
pde5aa	XP_009305135.1	GAF	245..388	CDD:214500	43/171 (25%)
		GAF	415..558	CDD:307634	32/164 (20%)
		PDEase_I	664..894	CDD:306695	117/229 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920