DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pde11 and pde2a

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_021322214.1	Gene:	pde2a / 100332468	-ID:	-	Length:	851	Species:	Danio rerio

Alignment Length:	782	Identity:	235/782 - (30%)
Similarity:	384/782 - (49%)	Gaps:	78/782 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   382 PYYHCHQRPQRLS----RNELKQLDEKELIFELVKDICNE---LEVRTLCHKILQNVS------- 432
            |:...|..|....    .|:.::||.|      :..:|.|   |:..:|..|::..:.
Zfish   100 PHAQSHNAPVEAKPSPPANDYRELDRK------ILQLCGELYDLDASSLQLKVINYLQTETQSQC 158

  Fly   433 ---ILLNADRGSLFLVQGRCNGPDGLKKCLVSKLFDVCPRSTVEEMEQQDEVRVAWGTGIAGHVA 494
               :|::.|...||              |.|           |.:...::|:......|..|.|.
Zfish   159 CCLLLVSEDNHQLF--------------CQV-----------VGDKILEEEISFPLMFGRFGQVV 198

  Fly   495 ESGEPVNIPDAYQ--DERFNCEIDSLTGYRTKALLCMP-IKDSSGDVIGVAQVINKMNGECFSEI 556
            |:.:.:.:.|..|  ....:.:|..|.|....::||:| :..::|.|:.:|...||:.|:.:.|.
Zfish   199 ETKKSITLQDVSQVTHTHTHMQIQQLLGSEPNSMLCVPVVSQATGQVVALACTFNKLGGQRYMEA 263

  Fly   557 DEKVFSSYLQFCGIGLRNAQLYEKSQLEIKRNQVLLDLARMIFEEQSTIEHMVFRILTHMQSLIQ 621
            ||.|......:....|.:...::|.|......|.||.:|:.:|.....:..::..|:...::|..
Zfish   264 DEHVIQHCFCYTSTVLTSTLAFQKEQKLKFECQALLQVAKNLFTHLDDVSVLLQEIIVEARNLSN 328

  Fly   622 CQRVQILLVHEADKGSFSRVFDFEANDLSEEEATSRTSPYESRFPINIGITGHVATTGETVNVPN 686
            .:...:.|:........::|||  ...::::|.       |.|.|.:.||.|||||||:.:|:.:
Zfish   329 AEICSVFLLDRVSHELVAKVFD--GGVVNDDEK-------EFRIPADQGIAGHVATTGKILNIKD 384

  Fly   687 AYEDDRFDASVDENSCFKHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCG 751
            ||....|...||:::.|:.|:|||..||:...::|||.:|.||.|...|.:.||:...||:|:||
Zfish   385 AYSHPLFYRGVDDSTGFRTRNILCFPIKDENEEVIGVAELXNKTNGPWFNRFDEDLATAFSIYCG 449

  Fly   752 MGIHNTHMYEKAIVAMAKQSVTLEVLSYHASATMDEAHRLRRLRVPSA--VHFRLHDFKFDDIHF 814
            :.|.::.:|::...|..:..:..|::.||...:.:|..:|..:.:.|.  :|....:|.:.....
Zfish   450 ISIAHSLLYKRVHEAQFRSHLANEMMMYHMKVSEEEVSKLLTIGIESVQKIHANFAEFTYTPRSL 514

  Fly   815 EDDDTLKACLRMFLDLDFVERFHIDYEVLCRWLLSVKKNYRNVTYHNWRHAFNVAQMMFAILTTT 879
            .||:|..|.|.||.|:.|:..:.||...|.|:.|.|||.||:..||||.|||:|:...:.:....
Zfish   515 PDDNTPMAVLSMFEDMGFINTYKIDLHTLARFCLMVKKGYRDPPYHNWMHAFSVSHFCYLLYKNL 579

  Fly   880 QWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASSPLAQLYST--STMEHHHFDQCLMILNS 942
            :......:||.|||.:.|:||||||||||||||:.:.|.||.|||:  |.||.|||.|.:.|||:
Zfish   580 ELSNYLQDIEILALFVSCMCHDLDHRGTNNSFQVASQSVLAALYSSEGSVMERHHFAQAIAILNT 644

  Fly   943 PGNQILANLSSDDYCRVIRVLEDAILSTDLAVY---FKKRGPFLESVSQPTSYWVAEEPRALLRA 1004
            .|..|....|..||.|::.::.|.||:||||.:   ||......:....|.:    ...|:||..
Zfish   645 HGCNIFEKFSRKDYQRMLDLMRDIILATDLAHHLRIFKDLQKMADVGFNPNN----RTHRSLLLC 705

  Fly  1005 MSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNITPIDIMNREKEDELPMMQVNFID 1069
            :.||.||||..||.|:..:::|:|:..|||.|||:||...| .|.::|:|||. .:|.:|::|::
Zfish   706 LLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAMGN-RPSEMMDREKA-YIPELQISFME 768

  Fly  1070 SICLPIYEAFATLSDKLEPLVEGVRDNRGHWIDLADV-----VKTKTSQDQEPEEEQQQQNVISN 1129
            .|.:|||:....:..:...|.|.|..||..|..::..     :.:..|.|...||.:..|:..:.
Zfish   769 HIAMPIYKLLQEIFPRSAELYERVSANREQWAKVSHKFTIRGLPSNNSLDFLDEEFEMLQSQGAF 833

  Fly  1130 GD 1131
            ||
Zfish   834 GD 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500	34/174 (20%)
		GAF	611..762	CDD:214500	49/150 (33%)
		PDEase_I	859..1094	CDD:278654	97/239 (41%)
pde2a	XP_021322214.1	GAF	138..289	CDD:214500	34/175 (19%)
		GAF	311..462	CDD:214500	49/159 (31%)
		PDEase_I	559..789	CDD:306695	95/235 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D114875at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.920