DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pde11 and pde1b

DIOPT Version :9

Sequence 1:	NP_001286044.1	Gene:	Pde11 / 35107	FlyBaseID:	FBgn0085370	Length:	1451	Species:	Drosophila melanogaster
Sequence 2:	XP_017946519.1	Gene:	pde1b / 100036722	XenbaseID:	XB-GENE-987197	Length:	554	Species:	Xenopus tropicalis

Alignment Length:	513	Identity:	128/513 - (24%)
Similarity:	213/513 - (41%)	Gaps:	90/513 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 KHRSILCMAIKNSLGQIIGVIQLINKFNELDFTKNDENFVEAFAIFCGMGIHNTHMYEKAIVAMA 768
            |.||:|...:|......:.:::|  |.| |::|   .:.:||..|.....|.:|   :..:..|.
Frog    52 KLRSLLKYMVKQLENGEVNIVEL--KKN-LEYT---ASLLEAVYIDETRQILDT---DDELPEMR 107

  Fly   769 KQSVTLEVLSYHASA----------TMDEAHRLRRL----------------------------R 795
            ..||..||..:.||.          ..:|..|.|.:                            .
Frog   108 SDSVPSEVRDWLASTFTQQTRSTGRRSEEKPRFRSIVHAVQAGIFVERMFRRSYTAVGPNYSAAV 172

  Fly   796 VPSAVHFRLHDFKFDDI----HFEDDDTLKACLRMFLDL-DFVERFHIDYEVLCRWLLSVKK--- 852
            |.|..|..|.||   |:    ...:|..||..:...|.. :...||.|....|..:|.|::.
Frog   173 VNSLKHLDLWDF---DVFVLNRVSEDHALKTIVFELLSRHNLNSRFKIPVAFLMSFLDSLESGYG 234

  Fly   853 NYRNVTYHNWRHAFNVAQMMFAILTTTQWWKIFGEIECLALIIGCLCHDLDHRGTNNSFQIKASS 917
            .|:| .|||..||.:|.|.:...|..|.......|||.||:|.....||.:|.||.|||.|:..|
Frog   235 KYKN-PYHNQIHAADVTQTVHCFLLRTGMVHCLNEIEILAIIFAAAIHDFEHTGTTNSFHIQTKS 298

  Fly   918 PLAQLYS-TSTMEHHHFDQCLMILNSPGNQILANLSSDDYCRVIRVLEDAILSTDLAVYFKKRGP 981
            ..|.||: .|.:|:||......|:......|..||:.|::..:..::.:.:|:||::.:|::...
Frog   299 DCAILYNDRSVLENHHVSAVYRIMQDDEMNIFVNLTKDEFTELRSLVIEMVLATDMSCHFQQVKT 363

  Fly   982 FLESVSQPTSYWVAEEPRALLRAMSMTVCDLSAITKPWEIEKRVADLVSSEFFEQGDMEKQELNI 1046
            ...|:.|..:   .::.:||  ::.:...|:|..||.|::..|....:..|||.|||.| .|:.:
Frog   364 MKTSLQQLET---IDKSKAL--SLLLHAADISHPTKQWKVHARWTKALMEEFFRQGDKE-AEMGL 422

  Fly  1047 TPIDIMNREKEDELPMMQVNFIDSICLPIYEAFATLSDK-LEPLVE---------GVRDNRGHW- 1100
             |...:...|...:...|:.||:.|..|.:.....:::| :.||||         .|..:...|
Frog   423 -PFSPLCDRKSTLVAQSQIGFIEFIVDPTFSVLTDVAEKTVLPLVEERSKSKSTASVNQSSSQWR 486

  Fly  1101 ---ID--------LADVVKTKTSQDQEPEEEQQQ-QNVISNGDCKAMSDDDVAASEAE 1146
               ||        .||:...:|:..:..:|.:|: :...::|.....|.|:::..|.:
Frog   487 QPSIDDHSEMGDINADIKSFRTTWTKYIQENKQKWKERAASGITNQTSVDELSPCEEQ 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pde11	NP_001286044.1	GAF	420..582	CDD:214500
		GAF	611..762	CDD:214500	15/57 (26%)
		PDEase_I	859..1094	CDD:278654	71/245 (29%)
pde1b	XP_017946519.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D904682at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010