DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10211 and Pxdn

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_006515268.1	Gene:	Pxdn / 69675	MGIID:	1916925	Length:	1503	Species:	Mus musculus

Alignment Length:	1297	Identity:	370/1297 - (28%)
Similarity:	560/1297 - (43%)	Gaps:	266/1297 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 THALPDAEVVIEQLQR-HVEGELRHAHITAMLPAWGQLLANDLVEVGQLPISGKC---------- 165
            ||.:|.....:|.::| .::....|.....:   |...|.....:.|....:..|
Mouse   196 THLVPGTFSQLESMKRLRLDSNALHCDCEIL---WLADLLKTYAQSGNAQAAATCEYPRRIQGRS 257

  Fly   166 ----------CERDSAVKDPSELQHCFVRAGP----DCKEYKRSAPGF-----DLEACQKHTRQQ 211
                      |||.....:|   |...|.:|.    .|:......|..     :.|...| |..:
Mouse   258 VATITPEELNCERPRITSEP---QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMK-TDSR 318

  Fly   212 MNIASAYIDGSGLYGSTRHEFDQLRTYISGGVKVESCKYCQVAGATGALHRALLQQHNNIGERLS 276
            :|:..   ||:.:..:|: |.|:         .|..|....||| ........|:...:......
Mouse   319 LNLLD---DGTLMIQNTQ-EADE---------GVYQCMAKNVAG-EAKTQEVTLRYLGSPARPTF 369

  Fly   277 HINPDWSE----EDVFLEARRIITAT---IQHITYNEF----LPLVLGQETTAKEGLRL--TAEK 328
            .|.|..:|    |.|.||.    :||   :..||:...    ||:......|...||.:  .|:.
Mouse   370 VIQPQNTEVLVGESVTLEC----SATGHPLPQITWTRGDRTPLPIDPRVNITPSGGLYIQNVAQS 430

  Fly   329 HSSNYSSSVRGGIYNEFATA-----AMPAFWSMYPPEMLAKKMSAHELLSIAALQKSLVPSQTNA 388
            .|..|:......:.:..|||     |:|.|  ...|:            |...::...|..|..|
Mouse   431 DSGEYTCFASNSVDSIHATAFIIVQALPQF--TVTPQ------------SRVVIEGQTVDFQCAA 481

  Fly   389 EGWSELALAVHRG-------RDHGVAS----YVHALDLCERRFADQSAANV--SFDTLAQVSNIP 440
            :|..:..:|..:|       |.|.|.|    .:..:.|.::...:..|.|:  |...:|.::..|
Mouse   482 KGHPQPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQP 546

  Fly   441 EEYITNLRDIYQN-ANDIDLLVGALLEEPVVGALFGPTISCLLSLQFEQLKQTDRFWYENEIPPS 504
                 .:..::.: .:|:.:.||..::.| ..:...|..:...:....|:.::.:|    .|.|.
Mouse   547 -----RVTPVFASIPSDMTVEVGTNVQLP-CSSQGEPEPAITWNKDGVQVTESGKF----HISPE 601

  Fly   505 SF-------TLD--QLKSIRQTTLSGLLCGSHQVSTAQSKAFILEDNYLNSILDCDQLPKFDLKP 560
            .|       |.|  :.:.:.:.|:     |...||...|
Mouse   602 GFLTINDVGTADAGRYECVARNTI-----GYASVSMVLS-------------------------- 635

  Fly   561 WQVNPEDEVHVEHVEVEPATKEAIAELSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSP 625
              ||..|........|..:..||||     .::.|:...:..|.:.:              .|||
Mouse   636 --VNVPDVSRNGDPYVATSIVEAIA-----TVDRAINSTRTHLFDSR--------------PRSP 679

  Fly   626 DGTAASFS-KANLAALNLANSSLIFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELTDTLQT 689
            :...|.|. ..:...:..|.:..|||.|...|.:.:.|     ..:.:.|..:::.|:|......
Mouse   680 NDLLALFRYPRDPYTVGQARAGEIFERTLQLIQEHVQH-----GLMVDLNGTSYHYNDLVSPQYL 739

  Fly   690 VDISGLLG-GAQKQLDTCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGI 753
            ..|:.|.| .|.::::.|   |..| .:..:||..|.||||::|.||.|||.|.|||.|.||:|.
Mouse   740 SLIANLSGCTAHRRVNNC---SDMC-FHQKYRTHDGTCNNLQHPMWGASLTAFERLLKAVYENGF 800

  Fly   754 SAPRLTGV------TGTALPNPRTISTT------IHPDISNLHTRYSLMVMQFAQFVDHDLTLTP 806
            :.||  |:      .|..||.||.:|||      |.||     .:::.|:||:.||:||||..|.
Mouse   801 NTPR--GINSQRQYNGHVLPMPRLVSTTLIGTEVITPD-----EQFTHMLMQWGQFLDHDLDSTV 858

  Fly   807 I-------HKGFHESIPSCRPCNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLP- 863
            :       ..|.|        |:|..:..|.|....:|..|   |.|.  ||.| |...:||.|
Mouse   859 VALSQARFSDGQH--------CSSVCSNDPPCFSVMIPPND---PRVR--SGAR-CMFFVRSSPV 909

  Fly   864 ---GQQSL-----GPRDQINQNTHFLDGSMVYGETTCLSNKLRGFSG-----RMNSTQVRGKELL 915
               |..||     .||:||||.|.::|.|.|||.|...:..:|..:.     |....|..||.||
Mouse   910 CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIRDLASHRGLLRQGIVQRSGKPLL 974

  Fly   916 PL--GPHPEC-KSRNGL---CFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQL 974
            |.  ||..|| :..|..   |||.||.||:||.|||::||.:.||||||...|..:||||:|:.:
Mouse   975 PFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTV 1039

  Fly   975 FHHARKIVSAQVQHIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRI 1039
            :|..||||.|::|||.:..:||:||     ...|:|:|  |.|:.|:||.:..:||.||.||||.
Mouse  1040 YHETRKIVGAEIQHITYRHWLPKIL-----GEVGMKML--GEYRGYDPSVNAGIFNAFATAAFRF 1097

  Fly  1040 GHSLLRPHIPRLSVQHQPV-EPPLLLRDGFFRMDALLQPGIIDEILRGL--VATPMETLDQFITG 1101
            ||:|:.|.:.||....:|: :..:.|...||....::..|.||.:||||  ||..|....|.:..
Mouse  1098 GHTLINPLLYRLDENFEPIPQGHVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNT 1162

  Fly  1102 EVTNHLFEDRKIPFSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTEVI-NR 1165
            |:|..||.  ......:||.|:||||.||||||.|::||..|||..|..:.||..||.:.|| .:
Mouse  1163 ELTERLFS--MAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIKSPVIREK 1225

  Fly  1166 FQKIYASVDDIDLFPGAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQL 1230
            .|::|.|..:|||||..|.|..:.|..:||||.|::..|||:||..||.|||  ||.| |:.|||
Mouse  1226 LQRLYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYE--NPGV-FSPAQL 1287

  Fly  1231 AEVRKVTLAKIVCENLEITGDMQRAAF---DLPSNFLNPRVPCASMPQIDLNAWRENVQGCQ 1289
            .::::.:||:|:|:|.:....:|:..|   :.|..:.:    |..:|::||..|::..:.|:
Mouse  1288 TQLKQTSLARILCDNSDNITRVQQDVFRVAEFPHGYSS----CEDIPRVDLRVWQDCCEDCR 1345

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139	90/482 (19%)
		An_peroxidase_like	209..524	CDD:265428	68/355 (19%)
		An_peroxidase	719..1245	CDD:281139	234/568 (41%)
		peroxinectin_like	871..1245	CDD:188655	168/388 (43%)
Pxdn	XP_006515268.1	leucine-rich repeat	94..112	CDD:275380
		leucine-rich repeat	113..127	CDD:275378
		LRR_8	115..171	CDD:338972
		LRR_8	160..219	CDD:338972	5/22 (23%)
		leucine-rich repeat	161..184	CDD:275378
		leucine-rich repeat	185..208	CDD:275378	3/11 (27%)
		leucine-rich repeat	209..221	CDD:275378	1/11 (9%)
		TPKR_C2	217..268	CDD:387596	5/53 (9%)
		I-set	271..358	CDD:369462	20/104 (19%)
		I-set	367..454	CDD:369462	22/90 (24%)
		Ig3_Peroxidasin	471..544	CDD:143222	15/72 (21%)
		Ig4_Peroxidasin	567..635	CDD:143223	13/77 (17%)
		peroxidasin_like	889..1328	CDD:188658	187/460 (41%)
		VWC	1439..1494	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820