Protein Alignment CG10211 and PTGS1

DIOPT Version :10

• Sequence 1: NP_609883.1
• Gene: CG10211 / 35106
• FlyBaseID: FBgn0032685
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: NP_000953.2
• Gene: PTGS1 / 5742
• HGNCID: 9604
• Length: 599
• Species: Homo sapiens
• Alignment Length: 613
• Identity: 137/613 - (22%)
• Similarity: 227/613 - (37%)
• Gaps: 134/613 - (21%)

  Fly   712 QCDA-----NSPFRTLSGRCNNLRN-----PNWGKSLTTFSR----LLPAQYEDGISAPRLTGVT 762
            |||.     :.|..|:.|....|||     |::...|.|..|    .:.|.:...:....:..|.
Human    55 QCDCTRTGYSGPNCTIPGLWTWLRNSLRPSPSFTHFLLTHGRWFWEFVNATFIREMLMRLVLTVR 119

  Fly   763 GTALPNPRTISTTIHPDIS-------NLHTRYSLMVMQFAQFVDHDLTLTPIHKGFHESIPSCRP 820
            ...:|:|.|.::. |..||       :.:||       ....|..|.. ||:.....:.:|..:.
Human   120 SNLIPSPPTYNSA-HDYISWESFSNVSYYTR-------ILPSVPKDCP-TPMGTKGKKQLPDAQL 175

  Fly   821 CNSRQTVHPECNPFPVPAGD---FYYPEVNVTSGERFCFPSMRSLPG-QQSLGPRDQINQNTHFL 881
            ...|..:..:.  .|.|.|.   |.:...:.|  .:|...|.:..|| .::||         |.:
Human   176 LARRFLLRRKF--IPDPQGTNLMFAFFAQHFT--HQFFKTSGKMGPGFTKALG---------HGV 227

  Fly   882 DGSMVYGETTCLSNKLRGF----------SGRMNSTQVRGKELL---PLGPHPECKSRNGLCFLG 933
            |...:||:......:||.|          .|.|....|....:|   |.|..|:.:...|....|
Human   228 DLGHIYGDNLERQYQLRLFKDGKLKYQVLDGEMYPPSVEEAPVLMHYPRGIPPQSQMAVGQEVFG 292

  Fly   934 GDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFNEFLPRI 998
                  ..|||....|.:||||||:.:.|:..:|.|..||||...|.|:..:...||..|::.::
Human   293 ------LLPGLMLYATLWLREHNRVCDLLKAEHPTWGDEQLFQTTRLILIGETIKIVIEEYVQQL 351

  Fly   999 ------LSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGH-SLLRPHIPRLSVQHQ 1056
                  |.::...|:|:    |..|:           |..|.....:.| ..|.|...::..|..
Human   352 SGYFLQLKFDPELLFGV----QFQYR-----------NRIAMEFNHLYHWHPLMPDSFKVGSQEY 401

  Fly  1057 PVEPPLLLRDGFFRMDALLQPGIIDEILRGLVATPMETLDQFITGEVTNHLFEDRKIPFSGIDLI 1121
            ..|..|      |....|:..|:  |.|       ::...:.|.|.:......|..|....:|:
Human   402 SYEQFL------FNTSMLVDYGV--EAL-------VDAFSRQIAGRIGGGRNMDHHILHVAVDV- 450

  Fly  1122 ALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTEVINRFQKIYASVDDIDLFPGAMTER 1186
               |:.:|:..:..:|.||....:|..|::.:|..|  .|:....:::|..:|.::.:||.:.|:
Human   451 ---IRESREMRLQPFNEYRKRFGMKPYTSFQELVGE--KEMAAELEELYGDIDALEFYPGLLLEK 510

  Fly  1187 PLQGGLVGPTLACIIGIQFRQLRK------CD-RFWYENQNPEVKFTEAQLAEVRKVTLAKIVCE 1244
            .....:.|.:: ..||..| .|:.      |. .:|    .|.....|.....|:..||.|:||.
Human   511 CHPNSIFGESM-IEIGAPF-SLKGLLGNPICSPEYW----KPSTFGGEVGFNIVKTATLKKLVCL 569

  Fly  1245 NLEITGDMQRAAFDLPSNFLNPRVPCAS 1272
            |.:            ...:::.|||.||
Human   570 NTK------------TCPYVSFRVPDAS 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_609883.1	An_peroxidase	69..537	CDD:460804
		An_peroxidase	719..1257	CDD:460804	128/584 (22%)
PTGS1	NP_000953.2	EGF_CA	32..69	CDD:238011	4/13 (31%)
		prostaglandin_endoperoxide_synthase	89..575	CDD:188648	122/567 (22%)