DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and ptgs2b

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001020675.1	Gene:	ptgs2b / 559020	ZFINID:	ZDB-GENE-041014-323	Length:	606	Species:	Danio rerio

Alignment Length:	646	Identity:	137/646 - (21%)
Similarity:	235/646 - (36%)	Gaps:	149/646 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   706 CPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPR-LTGVTGTALPNP 769
            |..|.|.....:...:.:..|:..|...:|::.||               |. ||.|..:..|:|
Zfish    24 CSHPCQNRGVCTEMGSDAYECDCTRTGYYGQNCTT---------------PEFLTWVKVSLKPSP 73

  Fly   770 RTIS--TTIHPDISNLHTRYSLM---VMQF-----AQFVDHDLTLTPIHKGFHESIPSCRPCNSR 824
            .|:.  .|....:.|:....|.:   :|::     |..:|...|....: |:.............
Zfish    74 NTVHYILTHFKSLWNIINNVSFLRNGIMRYVLTSRAHLIDSPPTFNADY-GYKSWEAYSNLSYYT 137

  Fly   825 QTVHPECNPFPVP---AGDFYYPEVNVTS-----------------------GERFCFPSMRSLP 863
            :|:.|.....|.|   ||....|:|.:.:                       .:.|.....:|
Zfish   138 RTLPPVPRDCPTPMGVAGKKELPDVKMLAEKLLLRRKFIPDPQRTNLMFAFFAQHFTHQFFKS-- 200

  Fly   864 GQQSLGPRDQINQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQVRGKELLP-----------L 917
             ....||......| |.:|.:.:||:.....:|||.|.......|:...|:.|           .
Zfish   201 -DMKKGPAFTTALN-HGVDLAHIYGQNLDRQHKLRLFKDGKLRYQILDGEVYPPTVSEVQVDMHY 263

  Fly   918 GPH-PECKSRNGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKI 981
            .|| ||.:.     |..|.:.....|||....|.:||||||:.:.|:..:|.|:.|:||..:|.|
Zfish   264 PPHVPESRR-----FAVGHEAFGLVPGLMMYATIWLREHNRVCDILKQEHPDWDDERLFQTSRLI 323

  Fly   982 VSAQVQHIVFNEFLPRILSWNAVNLYGLKLLPQGYY--KDYNPSCSPIVFNEFAAAAFRIG---H 1041
            :..:...||..:::..:               .|||  ..::|.   ::|||......||.   :
Zfish   324 LIGETIKIVIEDYVQHL---------------SGYYFKLKFDPE---LLFNERFQYQNRISSEFN 370

  Fly  1042 SLLRPHIPRLSVQHQPVEPPLLLRDGFFRMDA-------LLQPGII-DEILRGLVATPMETLDQF 1098
            :|...|         |:.|     |.|...|.       |....|: |..:..||    |:.::.
Zfish   371 TLYHWH---------PLMP-----DDFHIQDEVYNYQQFLFNTSILTDYGVNSLV----ESFNKQ 417

  Fly  1099 ITGEVTNHLFEDRKIPFSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTEVI 1163
            |.|.|..    .|.:..:.:.:...:|:.:|.....|.|.||...|:|...::.:::.|  .|:.
Zfish   418 IAGRVAG----GRNVAPAVLRVAIKSIENSRQMRYQSINAYRKRFNMKPYRSFEEMTGE--KEMA 476

  Fly  1164 NRFQKIYASVDDIDLFPGAMTERPLQGGLVGPTLA------CIIGIQFRQLRKCD-RFWYENQNP 1221
            ...:::|..||.::|:.|.:.|:|....:.|.|:.      .:.|:....:  |. .:|    .|
Zfish   477 AELEEMYGDVDAVELYAGLLVEKPRSNAIFGETMVEMGAPYSLKGLMGNPI--CSPEYW----KP 535

  Fly  1222 EVKFTEAQLAEVRKVTLAKIVCENLEITGDMQRAAFDLPSNFLNPRVPC---ASMPQIDLN 1279
            .....:.....|...:|..:||.|  :.|....|:|.:|:  :...:|.   ||..|.|.|
Zfish   536 STFGGKVGFEIVNSASLQNLVCNN--VNGPCPMASFYVPN--VKDSLPTTINASTSQSDRN 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	123/594 (21%)
		peroxinectin_like	871..1245	CDD:188655	91/405 (22%)
ptgs2b	NP_001020675.1	EGF_CA	21..57	CDD:238011	6/32 (19%)
ptgs2b	NP_001020675.1	prostaglandin_endoperoxide_synthase	77..565	CDD:188648	113/547 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810