DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10211 and Pxdn

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001258190.1	Gene:	Pxdn / 554172	RGDID:	1560694	Length:	1475	Species:	Rattus norvegicus

Alignment Length:	1298	Identity:	372/1298 - (28%)
Similarity:	563/1298 - (43%)	Gaps:	268/1298 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   112 THALPDAEVVIEQLQR-HVEGELRHAHITAMLPAWGQLLANDLVEVGQLPISGKC---------- 165
            ||.:|.....:|.::| .::....|.....:   |...|.....:.|....:..|
  Rat   168 THLVPGTFSQLESMKRLRLDSNALHCDCEIL---WLADLLKTYAQSGNAQAAATCEYPRRIQGRS 229

  Fly   166 ----------CERDSAVKDPSELQHCFVRAGP----DCKEYKRSAPGF-----DLEACQKHTRQQ 211
                      |||.....:|   |...|.:|.    .|:......|..     :.|...| |..:
  Rat   230 VATITPEELNCERPRITSEP---QDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMK-TDSR 290

  Fly   212 MNIASAYIDGSGLYGSTRHEFDQLRTYISGGVKVESCKYCQVAGATGALHRALLQQHNNIGERLS 276
            :|:..   ||:.:..:|: |.|:         .|..|....||| ....|...|:...:......
  Rat   291 LNLLD---DGTLMIQNTQ-EADE---------GVYQCMAKNVAG-EAKTHEVTLRYLGSPARPTF 341

  Fly   277 HINPDWSE----EDVFLEARRIITAT---IQHITYNEF----LPLVLGQETTAKEGLRL--TAEK 328
            .|.|..:|    |.|.||.    :||   :..||:...    ||:......|...||.:  .|:.
  Rat   342 VIQPQNTEVLVGESVTLEC----SATGHPLPQITWTRGDRTPLPIDPRVNITPSGGLYIQNVAQS 402

  Fly   329 HSSNYSSSVRGGIYNEFATA-----AMPAFWSMYPPEMLAKKMSAHELLSIAALQKSLVPSQTNA 388
            .|..|:......:.:..|||     |:|.|  ...|:            |...::...|..|..|
  Rat   403 DSGEYTCFASNSVDSIHATAFIIVQALPQF--TVTPQ------------SRVVIEGQTVDFQCEA 453

  Fly   389 EGWSELALAVHRG-------RDHGVAS----YVHALDLCERRFADQSAANV--SFDTLAQVSNIP 440
            :|:.:..:|..:|       |.|.|.|    .:..:.|.::...:..|.|:  |...:|.::..|
  Rat   454 KGYPQPVIAWTKGGSQLSVDRRHLVLSSGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQP 518

  Fly   441 EEYITNLRDIYQN-ANDIDLLVGALLEEPVVGALFGPTISCLLSLQFEQLKQTDRFWYENEIPPS 504
                 .:..::.: .:|:.:.||..::.| ..:...|..:...:....|:.::.:|    .|.|.
  Rat   519 -----RVTPVFASIPSDMTVEVGTNVQLP-CSSQGEPEPAITWNKDGVQVTESGKF----HISPE 573

  Fly   505 SF-------TLD--QLKSIRQTTLSGLLCGSHQVSTAQSKAFILEDNYLNSILDCDQLPKFDLKP 560
            .|       |.|  :.:.:.:.|:     |...||...|
  Rat   574 GFLTINDVGTADAGRYECVARNTI-----GYASVSMVLS-------------------------- 607

  Fly   561 WQVNPEDEVHVEHVEVEPATKEAIAELSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSP 625
              ||..|........|..:..||||     .::.|:...:..|.:.:              .|||
  Rat   608 --VNVPDVSRNGDPYVATSIVEAIA-----TVDRAINSTRTHLFDSR--------------PRSP 651

  Fly   626 DGTAASFS-KANLAALNLANSSLIFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELTDTLQT 689
            :...|.|. ..:...:..|.:..|||.|...|.:.:.|     ..:.:.|..:::.|:|......
  Rat   652 NDLLALFRYPRDPYTVGQARAGEIFERTLQLIQEHVQH-----GLMVDLNGTSYHYNDLVSPQYL 711

  Fly   690 VDISGLLG-GAQKQLDTCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGI 753
            ..|:.|.| .|.::::.|   |..| .:..:||..|.||||::|.||.|||.|.|||.|.||:|.
  Rat   712 SLIANLSGCTAHRRVNNC---SDMC-FHQKYRTHDGTCNNLQHPMWGASLTAFERLLKAVYENGF 772

  Fly   754 SAPRLTGV------TGTALPNPRTISTT------IHPDISNLHTRYSLMVMQFAQFVDHDLTLTP 806
            :.||  |:      .|..||.||.:|||      |.||     .:::.|:||:.||:||||..|.
  Rat   773 NTPR--GINSQRQYNGHVLPMPRLVSTTLIGTEVITPD-----EQFTHMLMQWGQFLDHDLDSTV 830

  Fly   807 I-------HKGFHESIPSCRPCNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLP- 863
            :       ..|.|        |:|..:..|.|....:|..|   |.|.  ||.| |...:||.|
  Rat   831 VALSQARFSDGQH--------CSSVCSNDPPCFSVMIPPND---PRVR--SGAR-CMFFVRSSPV 881

  Fly   864 ---GQQSL-----GPRDQINQNTHFLDGSMVYGETTCLSNKLRGFSG-----RMNSTQVRGKELL 915
               |..||     .||:||||.|.::|.|.|||.|...:..:|..:.     |....|..||.||
  Rat   882 CGSGMTSLLMNSVYPREQINQLTSYIDASNVYGSTDHEARSIRDLASHRGLLRQGIVQRSGKPLL 946

  Fly   916 PL--GPHPEC-KSRNGL---CFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQL 974
            |.  ||..|| :..|..   |||.||.||:||.|||::||.:.||||||...|..:||||:|:.:
  Rat   947 PFATGPPTECMRDENESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTV 1011

  Fly   975 FHHARKIVSAQVQHIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRI 1039
            :|..||||.|::|||.:..:||:||     ...|:|:|  |.|:.|:||.:..:||.||.||||.
  Rat  1012 YHETRKIVGAEIQHITYRHWLPKIL-----GEVGMKML--GEYRGYDPSVNAGIFNAFATAAFRF 1069

  Fly  1040 GHSLLRPHIPRLSVQHQPV-EPPLLLRDGFFRMDALLQPGIIDEILRGL--VATPMETLDQFITG 1101
            ||:|:.|.:.||....:|: :..:.|...||....::..|.||.:||||  ||..|....|.:..
  Rat  1070 GHTLINPLLYRLDENFEPIPQGHVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNT 1134

  Fly  1102 EVTNHLFEDRKIPFSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTEVI-NR 1165
            |:|..||.  ......:||.|:||||.||||||.|::||..|||..|..:.||..||.:.|| .:
  Rat  1135 ELTERLFS--MAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIKSPVIREK 1197

  Fly  1166 FQKIYASVDDIDLFPGAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQL 1230
            .|::|.|..:|||||..|.|..:.|..:||||.|::..|||:||..||.|||  ||.| |:.|||
  Rat  1198 LQRLYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYE--NPGV-FSPAQL 1259

  Fly  1231 AEVRKVTLAKIVCENLE----ITGDMQRAAFDLPSNFLNPRVPCASMPQIDLNAWRENVQGCQ 1289
            .::::.:||:|:|:|.:    :..|:.|.| :.|..:.:    |..:|::||..|::..:.|:
  Rat  1260 TQLKQTSLARILCDNSDNITRVQHDVFRVA-EFPHGYSS----CEDIPRMDLRVWQDCCEDCR 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139	91/482 (19%)
		An_peroxidase_like	209..524	CDD:265428	69/355 (19%)
		An_peroxidase	719..1245	CDD:281139	234/568 (41%)
		peroxinectin_like	871..1245	CDD:188655	168/388 (43%)
Pxdn	NP_001258190.1	leucine-rich repeat	42..60	CDD:275380
		leucine-rich repeat	63..84	CDD:275380
		LRR_4	107..148	CDD:289563
		LRR_8	108..167	CDD:290566
		leucine-rich repeat	109..132	CDD:275378
		LRR_4	132..172	CDD:289563	2/3 (67%)
		leucine-rich repeat	133..156	CDD:275378
		LRR_8	155..>192	CDD:290566	5/23 (22%)
		leucine-rich repeat	157..180	CDD:275378	3/11 (27%)
		leucine-rich repeat	181..193	CDD:275378	1/11 (9%)
		TPKR_C2	189..240	CDD:301599	5/53 (9%)
		Ig	243..330	CDD:299845	21/104 (20%)
		I-set	243..330	CDD:254352	21/104 (20%)
		I-set	339..426	CDD:254352	22/90 (24%)
		Ig	343..426	CDD:299845	22/86 (26%)
		I-set	430..516	CDD:254352	19/99 (19%)
		Ig3_Peroxidasin	443..516	CDD:143222	15/72 (21%)
		I-set	522..608	CDD:254352	17/123 (14%)
		Ig4_Peroxidasin	539..607	CDD:143223	13/77 (17%)
		An_peroxidase	738..1279	CDD:281139	235/573 (41%)
		peroxidasin_like	861..1300	CDD:188658	188/461 (41%)
		VWC	1411..1466	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920