DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and Tpo

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_062226.2	Gene:	Tpo / 54314	RGDID:	3900	Length:	914	Species:	Rattus norvegicus

Alignment Length:	938	Identity:	273/938 - (29%)
Similarity:	407/938 - (43%)	Gaps:	234/938 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   584 IAELSPELIEAAV-ERAKQELEERKRFEYEVWRTKGGIS-------ARSPDGTAASFSKANLAAL 640
            :.|.|..|::.|| ...|:.|::|           |.:|       ::.|:.|:.:.|:|
  Rat    42 VVETSQLLVDNAVYNTMKRNLKKR-----------GVLSPAQLLSFSKLPESTSGAISRA----- 90

  Fly   641 NLANSSLIFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELT-DTLQTV-DISGLLGGAQKQL 703
                         .||::|...:.:|:       |:.|:.:.|: |.|.|: ::||.|.....
  Rat    91 -------------AEIMETSIQVMKRE-------QSQFSTDALSADILATIANLSGCLPFMLP-- 133

  Fly   704 DTCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTGVT----GT 764
            ..||:   .|.||. :|.::|.|||..:|.||.|.|..:|.||..||||.|.||.....    |.
  Rat   134 PRCPD---TCLANK-YRPITGVCNNRDHPRWGASNTALARWLPPVYEDGFSQPRGWNPNFLYHGF 194

  Fly   765 ALPNPRTISTTIHPDISN----LHTRYSLMVMQFAQFVDHDLTLTP---IHKGFHESIPSCRPCN 822
            .||..|.::..: ..:||    ...:||..:..:.|::|||:.|||   ....|...:.....|.
  Rat   195 PLPPVREVTRHL-IQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCE 258

  Fly   823 SRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSL----PGQQ--------SLGPRDQIN 875
            ::.    .|.|..:|:.         :|....|.|..||.    .|.|        :..||.|:|
  Rat   259 NQN----PCFPIQLPSN---------SSRTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMN 310

  Fly   876 QNTHFLDGSMVYGETTCLSNKLRGFSG-----RMNSTQV-RGKELLPL-----GPHPECKSRNGL 929
            ..|.|||.|.|||.:..:..:||.:|.     |:|:..: .|:..||.     .|.|.....|..
  Rat   311 GLTSFLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDSGRAYLPFASAACAPEPGAPHANRT 375

  Fly   930 -CFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFNE 993
             |||.||.||||.|.|.|:||.:||||||:....:.:|.||:....:..|||:|.|..|.|...:
  Rat   376 PCFLAGDGRASEVPALAAVHTLWLREHNRLATAFKAINTHWSANTAYQEARKVVGALHQIITMRD 440

  Fly   994 FLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQHQPV 1058
            ::|:||..:|...|      .|.|:.|||:.:|.|.|.|:.||||.||:.:.|.:.||:...|..
  Rat   441 YIPKILGPDAFRQY------VGPYEGYNPTVNPTVSNVFSTAAFRFGHATVHPLVRRLNTDFQDH 499

  Fly  1059 E--PPLLLRDGFFRMDALLQPGIIDEILRGLVATP--METLDQFITGEVTNHLFEDRKIPFSGID 1119
            .  |.|.|.|.|||...|:|.|.:|.|:|||:|.|  ::..:|.:..|:|..||....:  ..:|
  Rat   500 TELPRLQLHDVFFRPWRLIQEGGLDPIVRGLLARPAKLQVQEQLMNEELTERLFVLSNV--GTLD 562

  Fly  1120 LIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT-EVINRFQKIYASVDDIDLFPGAM 1183
            |.:||:||.||||:|.||.:|..|.|.|.....:|::.|.. .::|:..::|...|:||::.|.:
  Rat   563 LASLNLQRGRDHGLPGYNEWREFCGLSRLETPAELNKAIANRSMVNKIMELYKHADNIDVWLGGL 627

  Fly  1184 TERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCENLEI 1248
            .|:.|.|...||..|||||.|.:.||..||||:||.:   .||:||..|:.|.:|.:::|:|..:
  Rat   628 AEKFLPGARTGPLFACIIGKQMKALRDGDRFWWENSH---VFTDAQRQELEKHSLPRVICDNTGL 689

  Fly  1249 TGDMQRAAFD------LPSNFLNPRVPCASMPQIDLNAWRE-----------------NVQGCQ- 1289
            |    |...|      .|.:|.:    |..:|.:||..|||                 |...|:
  Rat   690 T----RVPVDAFRIGKFPQDFES----CEEIPSMDLRLWRETFPQDDKCVFPEKVDNGNFVHCEE 746

  Fly  1290 ----------------IGNRNVRVGESAFPS-----------------PCTS------------C 1309
                            .|...|...::.:.|                 ||.|            |
  Rat   747 SGKLVLVYSCFHGYKLQGQEQVTCTQNGWDSEPPVCKDVNECADLTHPPCHSSAKCKNTKGSFQC 811

  Fly  1310 VCS--------------------------AEGA----QCASLRITDCGQLIRQW----PKEAILR 1340
            ||:                          |.||    ..|||..|    :|.:|    .|..:|.
  Rat   812 VCTDPYVLGEDEKTCIDSGRLPRASWVSIALGALLIGGLASLSWT----VICRWTHADKKSTLLI 872

  Fly  1341 DEVCNSQCGIYLTGQQASGFNPQQRQGQ 1368
            .|...::.|  ....|.||.:||:.:.|
  Rat   873 TERVTTESG--FRKSQESGISPQKAEVQ 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	198/565 (35%)
		peroxinectin_like	871..1245	CDD:188655	150/390 (38%)
Tpo	NP_062226.2	An_peroxidase	145..687	CDD:281139	198/566 (35%)
		thyroid_peroxidase	161..722	CDD:188657	202/593 (34%)
		CCP	730..783	CDD:153056	5/52 (10%)
		EGF_CA	784..826	CDD:284955	6/41 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	882..907		6/17 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820