Protein Alignment CG10211 and DUOX2

DIOPT Version :10

• Sequence 1: NP_609883.1
• Gene: CG10211 / 35106
• FlyBaseID: FBgn0032685
• Length: 1394
• Species: Drosophila melanogaster
• Sequence 2: NP_054799.4
• Gene: DUOX2 / 50506
• HGNCID: 13273
• Length: 1548
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 176/684 - (25%)
• Similarity: 262/684 - (38%)
• Gaps: 160/684 - (23%)

  Fly   692 ISGLLGGAQKQLDTCPEPSQQCDANS-PF--RTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGI 753
            ::|.||           ||...||.| |:  :...|..||||:...|.......|.:||.|.||:
Human    16 LTGSLG-----------PSGNQDALSLPWEVQRYDGWFNNLRHHERGAVGCRLQRRVPANYADGV 69

  Fly   754 SAPRLTGVTGTALPNPRTISTTIHPDISNLHTRYSLMVMQFAQFVDHDLTLTPIHKGFH------ 812
                ...:....|||||.:|......|:.|.:.             |:.|:..:..|:|
Human    70 ----YQALEEPQLPNPRRLSNAATRGIAGLPSL-------------HNRTVLGVFFGYHVLSDVV 117

  Fly   813 -ESIPSCRPCNSRQTVHPECNPF--PVPAGDFYYPEVNVTSGERFCFPSMRSLP--GQQSLGPRD 872
             ...|.| |........|..:|.  |...||...|           |...|..|  |:....|||
Human   118 SVETPGC-PAEFLNIRIPPGDPVFDPDQRGDVVLP-----------FQRSRWDPETGRSPSNPRD 170

  Fly   873 QINQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQVRGKELLPLGPHPEC--KSRNGL------ 929
            ..||.|.:||||.:||.:...|:.||.|||..          |..||.|..  .|:|.|
Human   171 LANQVTGWLDGSAIYGSSHSWSDALRSFSGGQ----------LASGPDPAFPRDSQNPLLMWAAP 225

  Fly   930 -----------CFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVS 983
                       .:..|.:|.:.:|.|.|:...:.|.||...:.|...:|.|..|:||.||||.|.
Human   226 DPATGQNGPRGLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEELFQHARKRVI 290

  Fly   984 AQVQHIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRP-- 1046
            |..|:|...|:||..|.         |.||:  |..|.|...|.:..||..|:.:...:::.|
Human   291 ATYQNIAVYEWLPSFLQ---------KTLPE--YTGYRPFLDPSISPEFVVASEQFFSTMVPPGV 344

  Fly  1047 HIPRLSVQHQPVEPPLLLRDGFFRMDALL---------QPGI-----IDEILRGLVATPMETLDQ 1097
            ::...|...:.|     |..||....||.         .|.:     ::|:|.|:.:...|..|.
Human   345 YMRNASCHFRKV-----LNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELLLGMASQISELEDN 404

  Fly  1098 FITGEVTNHLFEDRKIPFSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTEV 1162
            .:..::.::.....|  ||..|.:|.:|||.||.|:|||:.......|....||:||:..:..:|
Human   405 IVVEDLRDYWPGPGK--FSRTDYVASSIQRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQV 467

  Fly  1163 INRFQKIY-ASVDDIDLFPGAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFT 1226
            :.....:| ..:..::|..|.:.|   ..|..||..:.|:..||.:||..||:|:||....: |:
Human   468 LEATAALYNQDLSQLELLLGGLLE---SHGDPGPLFSAIVLDQFVRLRDGDRYWFENTRNGL-FS 528

  Fly  1227 EAQLAEVRKVTLAKIVCENLEITGDMQRAAFDLPSNFLNPRVPCASMPQIDLNAWRENVQGCQIG 1291
            :.::.::|..||..::...:.|.                   |.|..|
Human   529 KKEIEDIRNTTLRDVLVAVINID-------------------PSALQP----------------- 557

  Fly  1292 NRNVRVGESAFPSPCTSCVCSAEGAQCASLRITD 1325
              ||.|.....|.|....:.:....|||.|.:.|
Human   558 --NVFVWHKGAPCPQPKQLTTDGLPQCAPLTVLD 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_609883.1	An_peroxidase	69..537	CDD:460804
		An_peroxidase	719..1257	CDD:460804	154/586 (26%)
DUOX2	NP_054799.4	dual_peroxidase_like	38..594	CDD:188652	167/651 (26%)
		EFh	824..885	CDD:238008
		EFh	861..919	CDD:238008
		COG4097	1037..1548	CDD:443273
		NOX_Duox_like_FAD_NADP	1274..1548	CDD:99783