DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and MPO

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_000241.1	Gene:	MPO / 4353	HGNCID:	7218	Length:	745	Species:	Homo sapiens

Alignment Length:	756	Identity:	255/756 - (33%)
Similarity:	379/756 - (50%)	Gaps:	108/756 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   577 EPATKEAIAELSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSPDGTAA-----SFSKAN 636
            |.|....:.|:...|:.:::|.|||.:::..:...|      .|..|...|:|:     |:.|..
Human    47 EGAAPAVLGEVDTSLVLSSMEEAKQLVDKAYKERRE------SIKQRLRSGSASPMELLSYFKQP 105

  Fly   637 LAALNLANSSLIFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELTDTLQTVDISGLLGGAQK 701
            :||...|..:      ::.:...|:.:.|:.|.::   :..||..::....|...:|...|.|.:
Human   106 VAATRTAVRA------ADYLHVALDLLERKLRSLW---RRPFNVTDVLTPAQLNVLSKSSGCAYQ 161

  Fly   702 QLD-TCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPR--LTGVTG 763
            .:. ||||..:       :||::|.|||.|:|..|.|...|.|.|||:||||.|.|.  ..||..
Human   162 DVGVTCPEQDK-------YRTITGMCNNRRSPTLGASNRAFVRWLPAEYEDGFSLPYGWTPGVKR 219

  Fly   764 TALPNPRTISTTIHPDISNLHTRY-----------SLMVMQFAQFVDHDLTLTPIHKGFHESIPS 817
            ...|      ..:...:||...|:           |||.||:.|.:||||..||        .|:
Human   220 NGFP------VALARAVSNEIVRFPTDQLTPDQERSLMFMQWGQLLDHDLDFTP--------EPA 270

  Fly   818 CRP-------CNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLPG--QQSLGPRDQ 873
            .|.       |.:.....|.|.|..:|..|   |.:   ..:..|.|..||.|.  ..::..|:|
Human   271 ARASFVTGVNCETSCVQQPPCFPLKIPPND---PRI---KNQADCIPFFRSCPACPGSNITIRNQ 329

  Fly   874 INQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQV------RGKELLP---LGPHPEC----KS 925
            ||..|.|:|.|||||....|:..||..|.::....|      .|:.|||   |...| |    :|
Human   330 INALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLPFDNLHDDP-CLLTNRS 393

  Fly   926 RNGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIV 990
            ....|||.||.|:||.|.||::||..||||||:...|:.:||.|:||:|:..|||||.|.||.|.
Human   394 ARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLATELKSLNPRWDGERLYQEARKIVGAMVQIIT 458

  Fly   991 FNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQH 1055
            :.::||.:|...|:..|    ||.  |:.||.|..|.:.|.| ..|||.||:|::|.:.||..::
Human   459 YRDYLPLVLGPTAMRKY----LPT--YRSYNDSVDPRIANVF-TNAFRYGHTLIQPFMFRLDNRY 516

  Fly  1056 QPVEP-PLL-LRDGFFRMDALLQPGIIDEILRGLVATP--METLDQFITGEVTNHLFEDRKIPFS 1116
            ||:|| |.: |...||....::..|.||.|||||:|||  :...:|....|:...|||  ::...
Human   517 QPMEPNPRVPLSRVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFE--QVMRI 579

  Fly  1117 GIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT-EVINRFQKIYASVDDIDLFP 1180
            |:||.|||:||:||||:|.||.:|..|.|.:......|...:.. ::..:..:.|.:.::||::.
Human   580 GLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLARKLMEQYGTPNNIDIWM 644

  Fly  1181 GAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCEN 1245
            |.::|...:.|.|||.||||||.|||:||..||||:||   |..|:..|...:.:::|.:|:|:|
Human   645 GGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRFWWEN---EGVFSMQQRQALAQISLPRIICDN 706

  Fly  1246 LEITGDMQRAAF---DLPSNFLNPRVPCASMPQIDLNAWRE 1283
            ..||...:...|   ..|.:|:|    |:::|.::|.:|||
Human   707 TGITTVSKNNIFMSNSYPRDFVN----CSTLPALNLASWRE 743

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	211/565 (37%)
		peroxinectin_like	871..1245	CDD:188655	158/391 (40%)
MPO	NP_000241.1	myeloperoxidase_like	316..728	CDD:188656	164/424 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2375
Isobase	1	0.950	-	0	Normalized mean entropy	S5115
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.820