DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10211 and LPO

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_006142.1	Gene:	LPO / 4025	HGNCID:	6678	Length:	712	Species:	Homo sapiens

Alignment Length:	740	Identity:	249/740 - (33%)
Similarity:	361/740 - (48%)	Gaps:	111/740 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 LSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSPDGTAASFSKANLAALNLANSSLIFEL 651
            :|..:.:|.|:..|..|:.|.|.       |..:|:.:|
Human    34 ISDTVSQAKVQVNKAFLDSRTRL-------KTAMSSETP-------------------------- 65

  Fly   652 TSNEIVKTLNHITRRKR------QIFNPN-----QNAFNRNELTDTLQTVDISGLLG-GAQKQLD 704
            ||.::.:.|.|...|.|      |::..:     |.|...|....:|....:|..:| ||
Human    66 TSRQLSEYLKHAKGRTRTAIRNGQVWEESLKRLRQKASLTNVTDPSLDLTSLSLEVGCGA----- 125

  Fly   705 TCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAP--RLTGVT--GTA 765
              |.|..:||..||:||::|.|||.|.|..|.:....:|.|||:||||:|.|  ...|.|  |..
Human   126 --PAPVVRCDPCSPYRTITGDCNNRRKPALGAANRALARWLPAEYEDGLSLPFGWTPGKTRNGFP 188

  Fly   766 LPNPRTISTTIHPDISN---LHTRYSLMVMQFAQFVDHDLTLTP-IHKGFHESIPSCRPCNSRQT 826
            ||..|.:|..|...::.   |....||:.||:.|.|||||...| ...|..|.  |...|:....
Human   189 LPLAREVSNKIVGYLNEEGVLDQNRSLLFMQWGQIVDHDLDFAPDTELGSSEY--SKAQCDEYCI 251

  Fly   827 VHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRS-----LPGQQSLGPRDQINQNTHFLDGSMV 886
            ....|.|...|..|   |:.. |.|:  |.|..|:     .|..:||. |:|||..|.|||.|.|
Human   252 QGDNCFPIMFPPND---PKAG-TQGK--CMPFFRAGFVCPTPPYKSLA-REQINALTSFLDASFV 309

  Fly   887 YGETTCLSNKLRGFS---GRMNSTQVRGKELLPLGPHPE-----CKSRNGL----CFLGGDDRAS 939
            |.....|:::||..|   |.|...|......||..|:..     |:..|..    |||.||.|||
Human   310 YSSEPSLASRLRNLSSPLGLMAVNQEVSDHGLPYLPYDSKKPSPCEFINTTARVPCFLAGDSRAS 374

  Fly   940 EQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFNEFLPRILSWNAV 1004
            |...|...||.|||||||:...|:.:||.|:||:|:..||||:.|.||.|.|.::||.:|..:.
Human   375 EHILLATSHTLFLREHNRLARELKRLNPQWDGEKLYQEARKILGAFVQIITFRDYLPILLGDHM- 438

  Fly  1005 NLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQHQP--VEPPLLLRDG 1067
                .|.:|.  |:.|:.|..|.:.|.| ..|||.||..:...:.||...:||  .||.|.|...
Human   439 ----QKWIPP--YQGYSESVDPRISNVF-TFAFRFGHLEVPSSMFRLDENYQPWGPEPELPLHTL 496

  Fly  1068 FFRMDALLQPGIIDEILRGLVATPMETLDQ--FITGEVTNHLFEDRKIPFSGIDLIALNIQRARD 1130
            ||....:::.|.||.::|||:|...:.:.|  .:|||:.|.||:... ...|.||.|:|.||.||
Human   497 FFNTWRMVKDGGIDPLVRGLLAKKSKLMKQNKMMTGELRNKLFQPTH-RIHGFDLAAINTQRCRD 560

  Fly  1131 HGIPSYNNYRALCNLKRATNWNDLSREIPTEVI-NRFQKIYASVDDIDLFPGAMTERPLQGGLVG 1194
            ||.|.||::||.|:|.:.....:|:..:.:::: .:...:|.:.|:||::.||:.|..::.|.||
Human   561 HGQPGYNSWRAFCDLSQPQTLEELNTVLKSKMLAKKLLGLYGTPDNIDIWIGAIAEPLVERGRVG 625

  Fly  1195 PTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCENLEITGDMQRAAF-- 1257
            |.|||::|.||:|:|..||||:|  ||.| ||..|...::|::.:::||:|..|| .:.|..|
Human   626 PLLACLLGKQFQQIRDGDRFWWE--NPGV-FTNEQKDSLQKMSFSRLVCDNTRIT-KVPRDPFWA 686

  Fly  1258 -DLPSNFLNPRVPCASMPQIDLNAW 1281
             ..|.:|    |.|:::.::||:.|
Human   687 NSYPYDF----VDCSAIDKLDLSPW 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	206/555 (37%)
		peroxinectin_like	871..1245	CDD:188655	150/390 (38%)
LPO	NP_006142.1	An_peroxidase	138..674	CDD:281139	206/556 (37%)
LPO	NP_006142.1	myeloperoxidase_like	283..694	CDD:188656	160/428 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	339	1.000	Inparanoid score	I2375
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.870