DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and Ptgs1

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_058739.4	Gene:	Ptgs1 / 24693	RGDID:	3439	Length:	602	Species:	Rattus norvegicus

Alignment Length:	563	Identity:	120/563 - (21%)
Similarity:	199/563 - (35%)	Gaps:	142/563 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   761 VTGTALPNPRTISTTIHPDIS-------NLHTRYSLMVMQFAQFVDHDLTLTPIHKGFHESIPSC 818
            |....:|:|.|.:|. |..||       :.:||       ....|..|.. ||:.....:.:|..
  Rat   121 VRSNLIPSPPTYNTA-HDYISWESFSNVSYYTR-------ILPSVPKDCP-TPMGTKGKKQLPDI 176

  Fly   819 RPCNSRQTVHPECNPFPVPAGD---FYYPEVNVTSGERFCFPSMRSLPG-QQSLGPRDQINQNTH 879
            .....|..:..|.  .|.|.|.   |.:...:.|  .:|...|.:..|| .::||         |
  Rat   177 HLLAQRLLLRREF--IPAPQGTNVLFAFFAQHFT--HQFFKTSGKMGPGFTKALG---------H 228

  Fly   880 FLDGSMVYGETTCLSNKLRGFSGRMNSTQVRGKEL-------------LPLGPHPECKSRNGLCF 931
            .:|...:||::......||.|.......||...|:             .|.|..||.:...|...
  Rat   229 GVDLGHIYGDSLERQYHLRLFKDGKLKYQVLDGEVYPPSVEQASVLMRYPPGVPPEKQMAVGQEV 293

  Fly   932 LGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFNEFLP 996
            .|      ..|||....|.:||||||:.:.|:..:|.|:.||||...|.|:..:...|:..|::.
  Rat   294 FG------LLPGLMLFSTIWLREHNRVCDLLKEEHPTWDDEQLFQTTRLILIGETIKIIIEEYVQ 352

  Fly   997 RILSWNAVNLYGLKLLPQGYYKD--YNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQH---- 1055
            .:               .||:..  ::|.   ::|.    |.|:..:.:      .|...|
  Rat   353 HL---------------SGYFLQLKFDPE---LLFR----AQFQYRNRI------ALEFNHLYHW 389

  Fly  1056 QPVEPPLLLRDGF-------------FRMDALLQPGIIDEILRGLVATPMETLDQFITGEVTNHL 1107
            .|:.|     |.|             |....|:..|:             |.|....:.:....:
  Rat   390 HPLMP-----DSFQVGSQEYSYEQFLFNTSMLVDYGV-------------EALVDAFSRQRAGRI 436

  Fly  1108 FEDRKIPFSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTEVINRFQKIYAS 1172
            ...|...:..:.:....|:.:|:..:.|:|.||....||..|::.:.:.|  .|:....:::|..
  Rat   437 GGGRNFDYHVLHVAEDVIKESREMRLQSFNEYRKRFGLKPYTSFQEFTGE--KEMAAELEELYGD 499

  Fly  1173 VDDIDLFPGAMTERPLQGGLVGPTLACIIGIQFRQLRK------CD-RFWYENQNPEVKFTEAQL 1230
            :|.::.:||.|.|:.....|.|.:: ..:|..| .|:.      |. .:|    .|.....:...
  Rat   500 IDALEFYPGLMLEKCQPNSLFGESM-IEMGAPF-SLKGLLGNPICSPEYW----KPSTFGGDVGF 558

  Fly  1231 AEVRKVTLAKIVCENLEITGDMQRAAFDLP-------SNFLNP 1266
            ..|...:|.|:||.|   |......:|.:|       |.|:.|
  Rat   559 NIVNTASLKKLVCLN---TKTCPYVSFRVPDYPGDDGSVFVRP 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	113/533 (21%)
		peroxinectin_like	871..1245	CDD:188655	85/412 (21%)
Ptgs1	NP_058739.4	EGF_CA	35..72	CDD:238011
Ptgs1	NP_058739.4	prostaglandin_endoperoxide_synthase	92..578	CDD:188648	115/541 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810