DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10211 and IGSF9B

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_001264214.1	Gene:	IGSF9B / 22997	HGNCID:	32326	Length:	1437	Species:	Homo sapiens

Alignment Length:	1132	Identity:	212/1132 - (18%)
Similarity:	322/1132 - (28%)	Gaps:	443/1132 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 WCLCASSLTLRIPEDLENAAINALSSERARSLTPCGSSAEAEGSVAGD---YDVCPPSKYRQPTA 74
            |.|.... ::||.|..|. |:...:.....:|...|.||.|. .|..|   :.|.|..:|||...
Human   374 WTLMEDG-SIRIEEATEE-ALGTYTCVPYNTLGTMGQSAPAR-LVLKDPPYFTVLPGWEYRQEAG 435

  Fly    75 E-----CNNVSHRKWGARGDIFQRLLAADYADGVSQPRTSKGTHALPDAEVVIEQLQR--HVEGE 132
            .     |        .|.||.|..:....    |.:|..||.: |||...:....|.:  |.|.|
Human   436 RELLIPC--------AAAGDPFPVITWRK----VGKPSRSKHS-ALPSGSLQFRALSKEDHGEWE 487

  Fly   133 LRHAHITAMLPAWGQLLANDLVEVGQLPISGKCCERDSAVKDPSELQHCFVRAGPDCKEYKRSAP 197
            ....::...:.|     :..|..:|..|                                  .||
Human   488 CVATNVVTSITA-----STHLTVIGTSP----------------------------------HAP 513

  Fly   198 GFDLEACQKHTRQQMNIASAYIDGSGLYGSTRHEFDQLRTYISGGVKVESCKYCQVAGATGALHR 262
            |        ..|.|:::.:|.:.....|              .||
Human   514 G--------SVRVQVSMTTANVSWEPGY--------------DGG-------------------- 536

  Fly   263 ALLQQHNNIGERLSHINP-DWSEEDVFLEARRIITATIQHITYNEFLPLVLGQETTAKEGLRLTA 326
              .:|..::..:.:...| ||....|......::..|::..|..:|  .||.|
Human   537 --YEQTFSVWMKRAQFGPHDWLSLPVPPGPSWLLVDTLEPETAYQF--SVLAQ------------ 585

  Fly   327 EKHSSNYSSSVRGGIYNEFATAAMPAFWSMYPPEMLAKKMSAHELLSIAALQKSLVPSQTN---- 387
                            |:..|:   ||..:.....||..::..|.|.:....:.|:.::|.
Human   586 ----------------NKLGTS---AFSEVVTVNTLAFPITTPEPLVLVTPPRCLIANRTQQGVL 631

  Fly   388 ----------------------AEGWSELALAVHRGRDHGV---ASYVHALDLCERRFADQSAAN 427
                                  ||.|..|        |.|:   .....|.||.:..:.:.....
Human   632 LSWLPPANHSFPIDRYIMEFRVAERWELL--------DDGIPGTEGEFFAKDLSQDTWYEFRVLA 688

  Fly   428 VSFDTLAQVSNIPEEYITNL---RDIYQNANDIDLLVGALLEEPVVGA--LFGPTISCLLSLQFE 487
            |..|.:::.|||.....|::   .|:.::.....:|.|.:.....:.|  ||....:|.::
Human   689 VMQDLISEPSNIAGVSSTDIFPQPDLTEDGLARPVLAGIVATICFLAAAILFSTLAACFVN---- 749

  Fly   488 QLKQTDRFWYENEIPPSSFTLDQLKSIRQTTLSGLLCGSHQVSTAQSKAFILEDNYLNSILDCDQ 552
              ||..|.....:.||.|.|..: ||:.....||
Human   750 --KQRKRKLKRKKDPPLSITHCR-KSLESPLSSG------------------------------- 780

  Fly   553 LPKFDLKPWQVNPEDEVHVEHVEVEPATKEAIAELSPELIEAAVERAKQELEERKRFEYEVWRTK 617
                     :|:||          ...|..|.:|.|.:..:.|.:|......|::...|:  :||
Human   781 ---------KVSPE----------SIRTLRAPSESSDDQGQPAAKRMLSPTREKELSLYK--KTK 824

  Fly   618 GGISARSPDGTAASFSKANLAALNLANSSLIFELTSNEIVKTLNHITRRK--RQIFNPNQNAFNR 680
            ..||::.     .|.:||...|               |....:..|:|..  |.:.:|
Human   825 RAISSKK-----YSVAKAEAEA---------------EATTPIELISRGPDGRFVMDP------- 862

  Fly   681 NELTDTLQTVDISGLLGGAQKQLDTCPEPSQQCDAN-SPFRTLSGRCNNLRNPNWGKSLTTFSRL 744
            .|:..:|::..|.|.  ...::.|..||..|..:.| .|....|...  |::.....|.:..|.|
Human   863 AEMEPSLKSRRIEGF--PFAEETDMYPEFRQSDEENEDPLVPTSVAA--LKSQLTPLSSSQESYL 923

  Fly   745 LPAQYED-----GISAP-----RLTGVTGTALPNPRTISTTIHPDISNLHTRYSLMVMQFAQFVD 799
            .|..|..     |:..|     ||........|.||
Human   924 PPPAYSPRFQPRGLEGPGGLEGRLQATGQARPPAPR----------------------------- 959

  Fly   800 HDLTLTPIHKG-FHESIPSCRPCNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLP 863
                  |.|.| ::..:.|..|        .|..|.|     ||.|||...      ..|:.|.|
Human   960 ------PFHHGQYYGYLSSSSP--------GEVEPPP-----FYVPEVGSP------LSSVMSSP 999

  Fly   864 GQQSLGP--RDQINQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQVRGKELLPLG-------- 918
            ...:.||  ...|.:.    :|......|..|:....|  ||  |.:..|:...|.|
Human  1000 PLPTEGPFGHPTIPEE----NGENASNSTLPLTQTPTG--GR--SPEPWGRPEFPFGGLETPAMM 1056

  Fly   919 -PH--PECKSRNGLCFLGGDDRASEQP--GLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHA 978
             ||  |.|           |...|.||  ||.                 ||:.|
Human  1057 FPHQLPPC-----------DVPESLQPKAGLP-----------------RGLPP----------- 1082

  Fly   979 RKIVSAQVQHIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSL 1043
               .|.||.     ...|.|||..|         |:| :...:|...|:
Human  1083 ---TSLQVP-----AAYPGILSLEA---------PKG-WAGKSPGRGPV---------------- 1113

  Fly  1044 LRPHIPRLSVQHQPVEPPLLLRDGFFR 1070
              |..|....|.:|::|  |:..|..|
Human  1114 --PAPPAAKWQDRPMQP--LVSQGQLR 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139	86/496 (17%)
		An_peroxidase_like	209..524	CDD:265428	60/349 (17%)
		An_peroxidase	719..1245	CDD:281139	76/378 (20%)
		peroxinectin_like	871..1245	CDD:188655	44/213 (21%)
IGSF9B	NP_001264214.1	IG_like	30..115	CDD:214653
		Ig	41..115	CDD:143165
		I-set	139..225	CDD:254352
		IGc2	153..210	CDD:197706
		I-set	229..321	CDD:254352
		Ig	235..321	CDD:299845
		IG_like	331..414	CDD:214653	12/42 (29%)
		Ig	<353..414	CDD:299845	12/42 (29%)
		IG_like	426..505	CDD:214653	22/96 (23%)
		Ig	442..505	CDD:299845	18/80 (23%)
		FN3	510..601	CDD:238020	25/201 (12%)
		FN3	617..699	CDD:238020	13/89 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	758..817		18/109 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	911..1081		53/259 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900