DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10211 and Tpo

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_011242158.1	Gene:	Tpo / 22018	MGIID:	98813	Length:	915	Species:	Mus musculus

Alignment Length:	924	Identity:	266/924 - (28%)
Similarity:	398/924 - (43%)	Gaps:	217/924 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   522 LLCG----SHQVSTAQSKAFILEDNYLNSILDCDQLPKFDLKPWQVNPEDEVHVEHVEVEPATKE 582
            :|||    ||.:|..::...:::....|::       |.:||..:|            :.||...
Mouse    29 ILCGKTMKSHVISAVETSQLMVDHAVYNTM-------KRNLKKREV------------LSPAQLL 74

  Fly   583 AIAELSPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSPDGTAASFSKANLAALNLANSSL 647
            :..:|                                     |:.|:.:.|:|
Mouse    75 SFFKL-------------------------------------PESTSGAISRA------------ 90

  Fly   648 IFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELTDTLQTVDISGLLGGAQKQL-----DTCP 707
                  .||::|...:.:|::..|:           ||.| :.||.|.:......|     ..||
Mouse    91 ------AEIMETSIQVMKREQSQFS-----------TDAL-SADILGTIANLSGCLPFMLPPRCP 137

  Fly   708 EPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTGVT----GTALPN 768
            :   .|.||. :|.::|.|||..:|.||.|.|..:|.||..||||.|.|:.....    |..||.
Mouse   138 D---TCLANK-YRPITGACNNRDHPRWGASNTALARWLPPVYEDGFSQPKGWNPNFLYHGFPLPP 198

  Fly   769 PRTISTTIHPDISN----LHTRYSLMVMQFAQFVDHDLTLTP---IHKGFHESIPSCRPCNSRQT 826
            .|.::..: ..:||    ...:||..:..:.|::|||:.|||   ....|...:.....|.::.
Mouse   199 VREVTRHL-IQVSNEAVTEDDQYSDFLPVWGQYIDHDIALTPQSTSTAAFWGGVDCQLTCENQN- 261

  Fly   827 VHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSL----PGQQ--------SLGPRDQINQNTH 879
               .|.|..:|:.         :||...|.|..||.    .|.|        :..||.|:|..|.
Mouse   262 ---PCFPIQLPSN---------SSGTTACLPFYRSSAACGTGDQGALFGNLSAANPRQQMNGLTS 314

  Fly   880 FLDGSMVYGETTCLSNKLRGFSG-----RMNSTQV-RGKELLPL-----GPHPECKSRNGL-CFL 932
            |||.|.|||.:..:..:||.:|.     |:|:..: .|:..||.     .|.|.....|.. |||
Mouse   315 FLDASTVYGSSPGVEKQLRNWSSSAGLLRVNTLHLDAGRAYLPFATAACAPEPGTPRTNRTPCFL 379

  Fly   933 GGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFNEFLPR 997
            .||.||||.|.|.|:||.:||||||:....:.:|.||:....:..|||:|.|..|.|...:::|:
Mouse   380 AGDGRASEVPALAAVHTLWLREHNRLASAFKAINKHWSANTAYQEARKVVGALHQIITMRDYIPK 444

  Fly   998 ILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSV--QHQPVEP 1060
            ||..:|...|      .|.|:.|||:.:|.|.|.|:.||||.||:.:.|.:.||:.  |.....|
Mouse   445 ILGPDAFRQY------VGPYEGYNPTVNPTVSNIFSTAAFRFGHATVHPLVRRLNTDFQEHTELP 503

  Fly  1061 PLLLRDGFFRMDALLQPGIIDEILRGLV--ATPMETLDQFITGEVTNHLFEDRKIPFSGIDLIAL 1123
            .|.|||.|||...|:|.|.:|.|:|||:  |..::...|.:..|:|..||....:  ..:||.:|
Mouse   504 RLQLRDVFFRPWRLIQEGGLDPIVRGLLARAAKLQVQGQLMNEELTERLFVLSNV--GTLDLASL 566

  Fly  1124 NIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT-EVINRFQKIYASVDDIDLFPGAMTERP 1187
            |:||.||||:|.||.:|..|.|.|.....:|::.|.. .::|:...:|...|:||::.|.:.|:.
Mouse   567 NLQRGRDHGLPDYNEWREFCGLSRLETPAELNKAIANRSMVNKIMDLYKHADNIDVWLGGLAEKF 631

  Fly  1188 LQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCENLEITGDM 1252
            |.|...||..|||||.|.:.||..||||:||.|   .||:||..|:.|.:|.:::|:|..:|
Mouse   632 LPGARTGPLFACIIGKQMKALRDGDRFWWENTN---VFTDAQRQELEKHSLPRVICDNTGLT--- 690

  Fly  1253 QRAAFD------LPSNFLNPRVPCASMPQIDLNAWRENVQGCQIGNRNVRVGESAFPSPCTSCVC 1311
             |...|      .|.:|.:    |..:|.:||..|||                 .||.. ..||.
Mouse   691 -RVPVDAFRIGKFPQDFES----CEDIPSMDLELWRE-----------------TFPQD-DKCVF 732

  Fly  1312 SAEGAQCASLRITDCGQLIRQWPKEAILRDEVCNSQC--GIYLTGQQASGFNPQQRQGQAQPRVT 1374
            ..|......:...:.|:|:..:             .|  |..|.||:.  ....|:...::|.|.
Mouse   733 PEEVDNGNFVHCEESGKLVLVY-------------SCFHGYKLQGQEQ--VTCTQKGWDSEPPVC 782

  Fly  1375 RSRNQNLFKFPDLT 1388
            :..|:    ..|||
Mouse   783 KDVNE----CADLT 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139	0/1 (0%)
		An_peroxidase_like	209..524	CDD:265428	0/1 (0%)
		An_peroxidase	719..1245	CDD:281139	199/565 (35%)
		peroxinectin_like	871..1245	CDD:188655	151/390 (39%)
Tpo	XP_011242158.1	thyroid_peroxidase	161..722	CDD:188657	203/593 (34%)
		CCP	730..783	CDD:153056	13/67 (19%)
		EGF_CA	784..826	CDD:311536	4/13 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820