DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and Ptgs2

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_035328.2	Gene:	Ptgs2 / 19225	MGIID:	97798	Length:	604	Species:	Mus musculus

Alignment Length:	549	Identity:	114/549 - (20%)
Similarity:	198/549 - (36%)	Gaps:	157/549 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   737 SLTTFSRLLPAQYEDGISAPRLTGVTGT-ALPNPRTISTTI--------HPDISNLHTRYSLMVM 792
            :|:.::|.||...:|   .|...||.|. .||:.:.:...:        .|..||      :|..
Mouse   130 NLSYYTRALPPVADD---CPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGSN------MMFA 185

  Fly   793 QFAQFVDHDLTLTPIHKGFHESIPSCRPCNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFP 857
            .|||...|....|...:|
Mouse   186 FFAQHFTHQFFKTDHKRG----------------------------------------------- 203

  Fly   858 SMRSLPG-QQSLGPRDQINQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQVRGKELLP----- 916
                 || .:.||         |.:|.:.:||||....:|||.|.......||.|.|:.|
Mouse   204 -----PGFTRGLG---------HGVDLNHIYGETLDRQHKLRLFKDGKLKYQVIGGEVYPPTVKD 254

  Fly   917 ------LGPH-PECKSRNGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQL 974
                  ..|| ||     .|.|..|.:.....|||....|.:||||||:.:.|:..:|.|..|||
Mouse   255 TQVEMIYPPHIPE-----NLQFAVGQEVFGLVPGLMMYATIWLREHNRVCDILKQEHPEWGDEQL 314

  Fly   975 FHHARKIVSAQVQHIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRI 1039
            |..:|.|:..:...||..:::..:..::    :.||..|:            ::||:......||
Mouse   315 FQTSRLILIGETIKIVIEDYVQHLSGYH----FKLKFDPE------------LLFNQQFQYQNRI 363

  Fly  1040 GHSL-----LRPHIP-RLSVQHQPVEPPLLLRDGFFRMDALLQPGIIDEILRGLVATPMETLDQF 1098
            ....     ..|.:| ..:::.|...    .:...:....||:.|                |.||
Mouse   364 ASEFNTLYHWHPLLPDTFNIEDQEYS----FKQFLYNNSILLEHG----------------LTQF 408

  Fly  1099 I---TGEVTNHLFEDRKIPFSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT 1160
            :   |.::...:...|.:|.:...:...:|.::|:....|.|.||...:||..|::.:|:.|  .
Mouse   409 VESFTRQIAGRVAGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGE--K 471

  Fly  1161 EVINRFQKIYASVDDIDLFPGAMTERPLQGGLVGPTLA------CIIGIQFRQLRKCD-RFWYEN 1218
            |:....:.:|:.:|.::|:|..:.|:|....:.|.|:.      .:.|:....:  |. ::|
Mouse   472 EMAAELKALYSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPI--CSPQYW--- 531

  Fly  1219 QNPEVKFTEAQLAEVRKVTLAKIVCENLE 1247
             .|.....|.....:...::..::|.|::
Mouse   532 -KPSTFGGEVGFKIINTASIQSLICNNVK 559

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	113/545 (21%)
		peroxinectin_like	871..1245	CDD:188655	88/401 (22%)
Ptgs2	NP_035328.2	EGF_CA	19..55	CDD:238011
Ptgs2	NP_035328.2	prostaglandin_endoperoxide_synthase	75..562	CDD:188648	114/549 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810