DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and Epx

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	NP_031972.2	Gene:	Epx / 13861	MGIID:	107569	Length:	716	Species:	Mus musculus

Alignment Length:	757	Identity:	256/757 - (33%)
Similarity:	378/757 - (49%)	Gaps:	120/757 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   582 EAIAELSPELIEAAVER---AKQELEERKRFEYEVWRTKGGISARSPDGTAA-----SFSKANLA 638
            |..|..||..:|.:|.|   |:.:|.....:.:    |:..|..|...|:|:     ::.|..:|
Mouse    22 EGTAPASPSPVEISVLRDCIAEAKLLVDTAYNH----TQKSIMQRLRSGSASPMDLLAYFKQPVA 82

  Fly   639 ALNLANSSLIFELTSNEIVKTLNH----ITRRKRQIFNPNQNAFNRNELTDTLQTVDISGLLGGA 699
            |             :..:|:..::    :...:.::.......||..::....|...:|...|.|
Mouse    83 A-------------TRRVVQAADYMHVALGLLEERLQPRGSRPFNATDVLTEPQLRLLSQASGCA 134

  Fly   700 -QKQLDTCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTGVT- 762
             |.|.:.|         ::.:||::|||||.::|..|.|....:|.|||:|||..|.|  .|.|
Mouse   135 LQDQAERC---------SNKYRTITGRCNNKKHPWLGASNQALARWLPAEYEDHRSLP--FGWTP 188

  Fly   763 -----GTALPNPRTISTTIHPDISNLHTRY-----------SLMVMQFAQFVDHDLTL---TPIH 808
                 |..||..|        |:||...|:           :||.||:.||:||||..   :|..
Mouse   189 GKRRNGFLLPLVR--------DVSNQIVRFPSKKLTSDRGRALMFMQWGQFIDHDLDFSPESPAR 245

  Fly   809 KGFHESIPSCRPCNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLPG--QQSLGPR 871
            ..|...:...:.|...    |.|.|..:|..|   |.:   ..:|.|.|..||.|.  |.....|
Mouse   246 VAFSMGVDCEKTCAQL----PPCFPIKIPRND---PRI---KNQRDCIPFFRSAPACPQNRNKVR 300

  Fly   872 DQINQNTHFLDGSMVYGETTCLSNKLR---GFSGRMNST---QVRGKELLPLGPHPE--C----K 924
            :|||..|.|:|.|||||....|:.:||   .|.|.:.:.   |..|:.|||.....|  |    :
Mouse   301 NQINALTSFVDASMVYGSEVTLALRLRNRTNFLGLLATNQRFQDNGRALLPFDNLHEDPCLLTNR 365

  Fly   925 SRNGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHI 989
            |....|||.||.|:||.|.|||:||.|:|||||:...||.:||||:|::|::.|||||.|.||.|
Mouse   366 SARIPCFLAGDTRSSETPKLTALHTLFVREHNRLAAELRRLNPHWSGDKLYNEARKIVGAMVQII 430

  Fly   990 VFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQ 1054
            .:.:|||.:|....:.    :.|  |.|:.|..:..|.|.|.| ..|||.||::|:|.:.||..|
Mouse   431 TYRDFLPLVLGRARIR----RTL--GPYRGYCSNVDPRVANVF-TLAFRFGHTMLQPFMFRLDSQ 488

  Fly  1055 HQPVEP--PLLLRDGFFRMDALLQPGIIDEILRGLVATP--METLDQFITGEVTNHLFED-RKIP 1114
            ::...|  .:.|...||....::..|.||.|||||:|||  :...|..:..|:.:.||:. |:|
Mouse   489 YRASAPNSHVPLSSVFFASWRIIHEGGIDPILRGLMATPAKLNRQDSMLVDELRDKLFQQVRRI- 552

  Fly  1115 FSGIDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT-EVINRFQKIYASVDDIDL 1178
              |:||.|||:||:||||:|.||.:|..|.|.:..|...|||.:.. ::..:|.::|.:.|:||:
Mouse   553 --GLDLAALNMQRSRDHGLPGYNAWRRFCGLSQPRNLAQLSRVLKNQDLARKFLRLYKTPDNIDI 615

  Fly  1179 FPGAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVC 1243
            :.||:.|..|.|..|||.|||:...|||:.|..||||::...   .||:.|...:|:::|::|||
Mouse   616 WVGAIAEPLLPGARVGPLLACLFENQFRRARDGDRFWWQKWG---VFTKRQRKALRRISLSRIVC 677

  Fly  1244 ENLEIT---GDMQRAAFDLPSNFLNPRVPCASMPQIDLNAWR 1282
            :|..||   .|:.||.. .|..|    |.|:.:|:::|:|||
Mouse   678 DNTGITTVSRDIFRANI-YPQGF----VSCSRIPKLNLSAWR 714

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	214/565 (38%)
		peroxinectin_like	871..1245	CDD:188655	159/391 (41%)
Epx	NP_031972.2	An_peroxidase	146..684	CDD:281139	216/570 (38%)
Epx	NP_031972.2	myeloperoxidase_like	288..700	CDD:188656	170/429 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2408
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820