DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10211 and pxdn

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_009291604.1	Gene:	pxdn / 100332937	-ID:	-	Length:	1468	Species:	Danio rerio

Alignment Length:	1456	Identity:	406/1456 - (27%)
Similarity:	611/1456 - (41%)	Gaps:	342/1456 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 RIP----EDLENA--------AINALSSERARSLTPCGSSAEAEGSVAGDYDVCPPSKYRQ-PTA 74
            |||    |||||.        .|.|:..|..:.|.    |.|.......:.:...|..:.. |..
Zfish    95 RIPRGAFEDLENLKYLYLYKNEIQAIDREAFKGLV----SLEQLYLHFNNIESLEPESFSHLPKL 155

  Fly    75 E-----CNNVSHRKWGARGDIFQRLLAADYADGVSQPRTSKGTHALP-DAEV--VIEQLQRHVEG 131
            |     .|.:||...|.    |..|        .|..|....::||. |.|:  :.:.|:::.|.
Zfish   156 ERLFLHNNRISHLALGT----FSHL--------QSMKRLRLDSNALHCDCELLWLADLLKQYAES 208

  Fly   132 ELRHAHITAMLP------AWGQLLANDLVEVGQLPISGKCCERDSAVKDPSELQHCFVRAGP--- 187
            ....|..|...|      :...|.|::|           .||......:|.::.   |.:|.
Zfish   209 GNAQAAATCDYPNRLQGRSVATLTAHEL-----------NCEVPRITSEPQDVD---VTSGNTVY 259

  Fly   188 -DCKEYKRSAPGF----DLEACQKHTRQQMNIASAYIDGSGLYGSTRHEFDQLRTYISGGVKVES 247
             .|:......|..    :..|.......::|:..   ||:.:...|| |.||         .|..
Zfish   260 FTCRAEGNPKPQIIWLRNNNALNMRDDTRLNLLE---DGTLMIQDTR-ETDQ---------GVYQ 311

  Fly   248 CKYCQVAGATGALHRALLQQHNNIGERLSHINPDWSE----EDVFLEARRIITATIQ---HITYN 305
            |....|||.. ......|:...:.......|.|..:|    |.|.||.    :||.|   .:|:.
Zfish   312 CMAKNVAGEV-KTSEVTLRYFRSPSRPSFVIQPQNTEVLVGESVTLEC----SATGQPQPRVTWT 371

  Fly   306 EFLPLVLGQETTAKEGLRLTAEKHSSNYSSSVR---GGIYNEFAT--------------AAMPAF 353
            .      |.::......|:........:..::.   ||.|..||:              .|.|.|
Zfish   372 R------GDQSALPVDPRINITPSGGLFIQNIHQADGGQYTCFASNNVDTIHANAYIIVQARPQF 430

  Fly   354 WSMYPPEMLAKKMSAHELLSIAALQKSLVPSQT-----NAEGWSELALAVHRG-------RDHGV 406
                               ::....:|::..||     .|.|:.:..:|..||       |.|.|
Zfish   431 -------------------TVTPQDQSVLEGQTVDFPCEASGFPQPVIAWTRGGSPLPNDRRHVV 476

  Fly   407 ASYVHALDLCERRFADQ-------------SAANVSFDTLAQVSNIPEEYITNLRDI-YQNANDI 457
            .| ..:|.:......||             :.|.|..:.|..|:.:   :.:..||: .::.:|:
Zfish   477 LS-TGSLRISRVALHDQGQYECQAVSPVGTARAAVHLNILQSVTPV---FTSAPRDLTVESGSDV 537

  Fly   458 DLLVGALLEEPVVGALFGPTISCLLSLQFEQLKQTDRFWYENEIPPSSFTLDQLKSIRQTTLSGL 522
            .:...|..|         ||.....|....|:.::.:|    .|.|..:.  ::..:      ||
Zfish   538 QIPCSAQGE---------PTPIITWSKDGVQITESGKF----HINPDGYL--EVHDV------GL 581

  Fly   523 LCGSHQVSTAQSKAFILEDNYLNSILDCDQLPKFDLKPWQVNPEDEVHVEHVEVEPATKEAIAEL 587
            ..|......|::.......:.:.::    |:|       ||:.|.:..     |..:.:|||..
Zfish   582 ADGGRYECVARNSIGYSSSSMVLTV----QVP-------QVSREGDPF-----VSTSLEEAIRS- 629

  Fly   588 SPELIEAAVERAKQELEERKRFEYEVWRTKGGISARSPDGTAASFSKANLAAL----------NL 642
                |.:|::..:::|.:.              |.|:|         |.|.||          ..
Zfish   630 ----INSAIDSTRRQLFDG--------------SPRTP---------AELLALFRYPRDPYTVEQ 667

  Fly   643 ANSSLIFELTSNEIVKTLNHITRRKRQ--IFNPNQNAFNRNELTDTLQTVDISGLLGG--AQKQL 703
            |.:..|||       :||..|.|...|  :.:.|..|:..|:|... :.:|:...|.|  |.:::
Zfish   668 ARAGEIFE-------QTLLLIQRHVNQGLMVDTNGTAYRYNDLVSP-RFLDMIANLSGCTAHRRI 724

  Fly   704 DTCPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTGVT-----G 763
            :.|   |..| .:..:||..|.||||::|.||.|||.|.|||...|::|.:.||  |.|     |
Zfish   725 NNC---SDIC-FHQKYRTHDGTCNNLQHPMWGASLTPFERLLKPVYDNGFNLPR--GTTERWHNG 783

  Fly   764 TALPNPRTIST------TIHPDISNLHTRYSLMVMQFAQFVDHDLTLTPIHKGFHESIPSCR--- 819
            ..||.||.:||      ||.||     .||:.|:||:.||:||||..|.:      |:...|
Zfish   784 YPLPLPRLVSTTMIGTETITPD-----DRYTHMLMQWGQFLDHDLDSTVV------SLSQSRFSD 837

  Fly   820 --PCNSRQTVHPECNPFPVPAGDFYYPEVNVTSGERFCFPSMRSLP----GQQSL-----GPRDQ 873
              .|.|..|..|.|.|...|..|   |... .:|.| |...:||.|    |..||     .||:|
Zfish   838 GQLCTSVCTNDPPCFPIMFPPND---PRQR-RNGAR-CMFFVRSSPVCGSGMTSLLMNSVYPREQ 897

  Fly   874 INQNTHFLDGSMVYGETTCLSNKLRGFSG-----RMNSTQVRGKELLPL--GPHPEC-KSRNGL- 929
            :||.|.::|.|.|||.:...:.::|..:.     |....|..||.|||.  ||..|| :..|..
Zfish   898 MNQLTSYIDASNVYGSSQHEAEEIRDLASHRGMLRQGIVQRTGKPLLPFATGPPTECMRDENESP 962

  Fly   930 --CFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQVQHIVFN 992
              |||.||.||:||.||||:||.:|||||||...|..:||||:|:.::|.|||||.||:|||.:|
Zfish   963 IPCFLAGDHRANEQLGLTAMHTVWLREHNRIASELLRLNPHWDGDTIYHEARKIVGAQMQHITYN 1027

  Fly   993 EFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPRLSVQHQP 1057
            ::||:||     ...|::::  |.|..|||:.:..:.|.||.||||.||:|:.|.:.||....||
Zfish  1028 QWLPKIL-----GEAGMRIM--GDYTGYNPNINAGILNAFATAAFRFGHTLINPILYRLDENFQP 1085

  Fly  1058 VEP-PLLLRDGFFRMDALLQPGIIDEILRGL--VATPMETLDQFITGEVTNHLFEDRKIPFSGID 1119
            ::. .:.|...||....::..|.||.:||||  ||..|....|.:..|:|..||.  ......:|
Zfish  1086 IQQGHISLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRMSTQLLNTELTERLFS--MAHAVALD 1148

  Fly  1120 LIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPT-EVINRFQKIYASVDDIDLFPGAM 1183
            |.|:||||.|||||||||:||..|||..|..:.||..||.. .|..:.|::|.:..::||||..|
Zfish  1149 LAAMNIQRGRDHGIPSYNDYRVFCNLTSAQTFEDLKNEIQNPSVREKLQRLYGTPLNVDLFPALM 1213

  Fly  1184 TERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLAKIVCENLEI 1248
            .|..:.|..:||||.|::..||::||..|||||||..   .|:.|||.::::.:|::::|:|.:.
Zfish  1214 AEELVPGSRLGPTLMCLLATQFKRLRDGDRFWYENPG---SFSPAQLTQLKQTSLSRVLCDNGDN 1275

  Fly  1249 TGDMQRAAF---DLPSNFLNPRVPCASMPQIDLNAWRENVQGCQI------------GNRNVRVG 1298
            ...:|..||   |||..:.:    ||.:|:|||..|::..:.|:.            |.|:....
Zfish  1276 ITRIQSDAFSVADLPHGYGS----CADLPKIDLRMWQDCCEDCRTKGQFNALSFHFRGRRSAEHS 1336

  Fly  1299 ESAFPSPCTSCVCSAEGAQCASLRIT 1324
            .:....|..:...::...:.|::.||
Zfish  1337 YAEEKKPANNLTENSSTLEDAAVNIT 1362

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139	98/527 (19%)
		An_peroxidase_like	209..524	CDD:265428	68/364 (19%)
		An_peroxidase	719..1245	CDD:281139	231/565 (41%)
		peroxinectin_like	871..1245	CDD:188655	164/388 (42%)
pxdn	XP_009291604.1	LRRNT	31..57	CDD:214470
		leucine-rich repeat	59..106	CDD:275378	6/10 (60%)
		LRR_4	105..146	CDD:289563	8/44 (18%)
		LRR_8	106..165	CDD:290566	11/62 (18%)
		leucine-rich repeat	107..130	CDD:275378	4/26 (15%)
		LRR_4	130..168	CDD:289563	7/37 (19%)
		leucine-rich repeat	131..154	CDD:275378	2/22 (9%)
		leucine-rich repeat	155..178	CDD:275378	7/34 (21%)
		leucine-rich repeat	179..191	CDD:275378	3/11 (27%)
		LRRCT	187..238	CDD:214507	12/61 (20%)
		Ig	241..328	CDD:299845	19/103 (18%)
		I-set	241..328	CDD:254352	19/103 (18%)
		Ig	341..424	CDD:299845	18/92 (20%)
		IG_like	343..424	CDD:214653	17/90 (19%)
		I-set	428..514	CDD:254352	19/105 (18%)
		Ig	441..514	CDD:299845	16/73 (22%)
		I-set	520..606	CDD:254352	16/109 (15%)
		Ig	537..605	CDD:299845	13/88 (15%)
		An_peroxidase	736..1277	CDD:281139	232/570 (41%)
		peroxidasin_like	857..1296	CDD:188658	184/459 (40%)
		VWC	1410..1461	CDD:214564
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920