DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10211 and tpo

DIOPT Version :9

Sequence 1:	NP_001286043.1	Gene:	CG10211 / 35106	FlyBaseID:	FBgn0032685	Length:	1394	Species:	Drosophila melanogaster
Sequence 2:	XP_031758614.1	Gene:	tpo / 100036738	XenbaseID:	XB-GENE-920152	Length:	872	Species:	Xenopus tropicalis

Alignment Length:	728	Identity:	235/728 - (32%)
Similarity:	358/728 - (49%)	Gaps:	106/728 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   648 IFELTSNEIVKTLNHITRRKRQIFNPNQNAFNRNELTDTLQTVDIS-----------GLLGGAQK 701
            :||  :|....::.|:....:.....|.:..::..|....::.|:|           .|.|...:
Frog    23 VFE--NNTDQNSVFHLDNIPQSALPRNSSQTDKTSLEQHPESEDVSHTGSSFEAVLANLTGCVPQ 85

  Fly   702 QLDT-CPEPSQQCDANSPFRTLSGRCNNLRNPNWGKSLTTFSRLLPAQYEDGISAPRLTG----- 760
            .|.. ||   ..|.|.. :|.::|.|||..||.||.:.|..:|.|||||||||..|:  |
Frog    86 TLSPFCP---NNCLAGK-YRHITGACNNRNNPAWGAANTLLARWLPAQYEDGIGEPK--GWREEF 144

  Fly   761 -VTGTALPNPRTISTTIHPDISNLHTR---------YSLMVMQFAQFVDHDLTLTPIHKGFHESI 815
             ..|..||..|.::..|      :|..         ||.:::::.|::|||:..||.......:|
Frog   145 LYNGFRLPQVREVTNKI------IHASSKAFREDDLYSHIIIEWGQYIDHDIAFTPQSVSKTPAI 203

  Fly   816 PSCRPCNSRQTVHPECNPFPVPAGD---------FYYPEVNVTSGE---RFCFPSMRSLPGQQSL 868
            .|....::.:.::| |.|..:...|         ||.......:|.   :|..||:        |
Frog   204 GSVDCKSTCENLYP-CYPIKLSEEDPLSQGGCIPFYRSSSACGTGRGGLKFGNPSL--------L 259

  Fly   869 GPRDQINQNTHFLDGSMVYGETTCLSNKLRGFSGRMNSTQVR------GKELLPLGPHPEC---- 923
            .||:|||..|.|:|.|.|||.:..|.:||:..|......:|.      .:|.||......|
Frog   260 NPREQINGLTSFIDASTVYGSSESLQHKLKNLSSEEGLLRVNVKYSDSSREYLPFETPSACMQDP 324

  Fly   924 ---KSRNGLCFLGGDDRASEQPGLTAIHTAFLREHNRIVEGLRGVNPHWNGEQLFHHARKIVSAQ 985
               .:....||..|:.||:|...|.|:||.:|||||||.:.|:.:|||||.|..:..|||||.|.
Frog   325 TADNAERIDCFFAGEGRANEVITLAAVHTLWLREHNRIAKALKKLNPHWNSETTYQEARKIVGAL 389

  Fly   986 VQHIVFNEFLPRILSWNAVNLYGLKLLPQGYYKDYNPSCSPIVFNEFAAAAFRIGHSLLRPHIPR 1050
            .|.|.|.:::|:||...|.:.|      .|.||.||...:|.:.|.|..||||.||:.:.|.:.|
Frog   390 HQIITFRDYMPKILGKAAYDQY------IGLYKGYNQKTNPSISNIFTTAAFRFGHATIPPMVHR 448

  Fly  1051 LSVQH--QPVEPPLLLRDGFFRMDALLQPGIIDEILRGLV--ATPMETLDQFITGEVTNHLFEDR 1111
            |:.|:  .|..|.|.|.:.|||...:::.|.:|.::|||:  :..::|....|..|:|..|.
Frog   449 LNSQYVDDPKYPSLPLNEVFFRPWRIVKEGGLDPLIRGLLGKSAKLQTQVDMINEELTEKLL--- 510

  Fly  1112 KIPFSG-IDLIALNIQRARDHGIPSYNNYRALCNLKRATNWNDLSREIPTE-VINRFQKIYASVD 1174
            .:..:| :||.:||:||.||||:|.||::|..|.|.|.....||...:..: ::.:...:|:..|
Frog   511 VMTNNGSMDLASLNLQRGRDHGLPGYNDWREFCGLSRLATPADLINAVSDQKLVAKMIALYSHPD 575

  Fly  1175 DIDLFPGAMTERPLQGGLVGPTLACIIGIQFRQLRKCDRFWYENQNPEVKFTEAQLAEVRKVTLA 1239
            :||::.|.:.|..|.|...||..||:||.|.:.||:.|||||||.|   .||:.|.:|:.|.:|:
Frog   576 NIDVWLGGLAEDFLPGARTGPLFACLIGKQMQALREGDRFWYENNN---IFTKIQRSELEKHSLS 637

  Fly  1240 KIVCENLEITGDMQRAAF---DLPSNFLNPRVPCASMPQIDLNAWRENVQ-GCQIGN-RNVRVGE 1299
            :::|:|..:: .:...||   :.|.||    |.|.|:|.|:|.||:|:.: |...|: |.:..|:
Frog   638 RVICDNTGLS-HVPLDAFLLGNYPDNF----VSCDSIPGINLEAWKESPEKGTTCGSPRKIENGD 697

  Fly  1300 SAFPSPCT---SC 1309
            .||.|..|   ||
Frog   698 FAFCSEATVIYSC 710

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10211	NP_001286043.1	An_peroxidase	69..524	CDD:281139
		An_peroxidase_like	209..524	CDD:265428
		An_peroxidase	719..1245	CDD:281139	195/571 (34%)
		peroxinectin_like	871..1245	CDD:188655	145/392 (37%)
tpo	XP_031758614.1	thyroid_peroxidase	116..679	CDD:188657	201/596 (34%)
		CCP	687..736	CDD:153056	9/24 (38%)
		EGF_CA	738..781	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D276568at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.010