DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	528	Identity:	141/528 - (26%)
Similarity:	253/528 - (47%)	Gaps:	89/528 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPSFDI----PKHFPKENIFSMQFV 97
            ||||.::.....|..:||.:                 :::.|..::    .|:: :..|||:.:
Mouse    37 SHWLSMKEIVEHLSERGHDI-----------------MVLVPEVNLLLGESKYY-RRKIFSVTY- 82

  Fly    98 SDFNNLELWWTIGLMTTEHAFKD----PKVKKLIESKDDHYDLVIIEQFFHE-----------AF 147
                :||     .|.|....|.:    |....:...::...::::::.||..           :|
Mouse    83 ----SLE-----ELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKDSATLSF 138

  Fly   148 L---MFGKRFNCPVVTIGTM--------------GYADNIDHAMG-ILTPWSLIPHLLLSHTDRM 194
            |   .|...|..|.:..|.:              |:..:::|.:| ..:|.|.:|......:|.|
Mouse   139 LRENKFDALFTDPAMPCGVILAEYLNLPSVYLFRGFPCSLEHMLGQSPSPVSYVPRFYTKFSDHM 203

  Fly   195 TFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSID 259
            ||.||..|..:::.:..:...:| .|.:.:|....:..:..|     .|.:| ||.|:......:
Mouse   204 TFPQRLANFIVNILENYLYYCLY-SKYEIIASDLLKRDVSLP-----SLHQN-SLWLLRYDFVFE 261

  Fly   260 LPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLD-NATYGVIYFSMGSYVKSTDLPQEKTALILKAF 323
            .|||.||.:|.:||.:.:|..:|..:.:.::: :..:|::.||:||.|  :::|::|...|.:|.
Mouse   262 YPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEAL 324

  Fly   324 GQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCV 388
            |::.|.|:|::......:|..|.::.||:||||:|.||..:.||||.|..|..|||..||||:.:
Mouse   325 GRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMM 389

  Fly   389 PLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLD 453
            ||:|||..|..:....|...:|...::|.|||...::|:||:..||.:.:.:|...:|.||.|||
Mouse   390 PLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLD 454

  Fly   454 EATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWR------------- 505
            .|.||:||::||:||.||:.....:..:||..|||:|.||......:::.::
Mouse   455 LAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKCFGGK 519

  Fly   506 -MIRRVHK 512
             .:::.||
Mouse   520 GRVKKSHK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	131/483 (27%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	131/483 (27%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	139/502 (28%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	139/521 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.760