DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and Ugt2b35

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001004271.1	Gene:	Ugt2b35 / 83808	RGDID:	620895	Length:	530	Species:	Rattus norvegicus

Alignment Length:	545	Identity:	161/545 - (29%)
Similarity:	262/545 - (48%)	Gaps:	104/545 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIISPSFDI---PKH--------FPK-- 88
            |||:.::....:|:::||.||                 ::.||..:   ||.        ||.
  Rat    34 SHWMNIKIILEELVQKGHEVT-----------------VLRPSASVFLDPKETSDLKFVTFPTSF 81

  Fly    89 -----ENIFSMQFVSDFNNLELW-----------WTIGLMTTEHAFKD-------------PKVK 124
                 ||.|: :||:      :|           :.:.|..|...:.|             ..:.
  Rat    82 SSHDLENFFT-RFVN------VWTYELPRDTCLSYFLYLQDTIDEYSDYCLTVCKEAVSNKQFMT 139

  Fly   125 KLIESKDDHYDLV----------IIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGILTP 179
            ||.|||   :|:|          :|.:.....|| :..||: |..||.        .:..|:|.|
  Rat   140 KLQESK---FDVVFSDAIGPCGELIAELLQIPFL-YSLRFS-PGYTIE--------KYIGGVLFP 191

  Fly   180 WSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKY---FQGSIEGPLPNVL 241
            .|.:|.:......:|||.:|.:|....||   ...|     .|...||.   |.....|....:.
  Rat   192 PSYVPMIFSGLAGQMTFIERVHNMICMLY---FDFW-----FQTFREKKWDPFYSKTLGRPTTLA 248

  Fly   242 DLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMGSY 305
            ::.....:.||.::..::.|.|..|.:..:||.|.:..|.||.|:::|:.:: .:||:.||:||.
  Rat   249 EIMGKAEMWLIRSYWDLEFPHPISPNVDYIGGLHCKPAKPLPKDIEDFVQSSGEHGVVVFSLGSM 313

  Fly   306 VKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFITHG 370
            |:  ::.:||..:|..|..|:.|:|:|:|:......|..|..:.||:||||:|.||..|.|:|||
  Rat   314 VR--NMTEEKANIIAWALAQIPQKVLWRFDGKKPPTLGPNTRLYKWLPQNDLLGHPKTKAFVTHG 376

  Fly   371 GIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQYKR 435
            |..|..|.|:.|:||:.:||:|:||.|....|.:|.|..:.|..::..|::..:|.:||:|.||:
  Rat   377 GANGIYEAIHHGIPMIGIPLFGEQHDNIAHMVAKGAAVEVNFRTMSKSDMLNALEEVINNPFYKK 441

  Fly   436 SALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFLAI 500
            :|:.:|....|.|..|||.|.||||:::||:||:||:|.|..:|.:||..|||:|.||....:.:
  Rat   442 NAMWLSTIHHDQPTKPLDRAVFWIEFVMRHKGAKHLRSLGHNLPWYQYHSLDVIGFLLTCVAVTV 506

  Fly   501 WLPWRMIRRVHKWWLKGESSNKLNE 525
            .|..:....|:::::|.|...| ||
  Rat   507 VLALKCFLFVYRFFVKKEKKTK-NE 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	146/501 (29%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	146/501 (29%)
Ugt2b35	NP_001004271.1	UDPGT	24..527	CDD:278624	158/539 (29%)
Ugt2b35	NP_001004271.1	egt	<270..489	CDD:223071	87/220 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm9018
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760