Protein Alignment Ugt301D1 and UGT2A3

DIOPT Version :10

• Sequence 1: NP_609882.1
• Gene: Ugt301D1 / 35105
• FlyBaseID: FBgn0032684
• Length: 530
• Species: Drosophila melanogaster
• Sequence 2: XP_011530549.1
• Gene: UGT2A3 / 79799
• HGNCID: 28528
• Length: 533
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 160/537 - (29%)
• Similarity: 263/537 - (48%)
• Gaps: 72/537 - (13%)

  Fly     8 KCWMLIFLIGLLEFGAGSRILFMGP---FPAP-SHWLWLEHFQNDLLRQGHHVT----------- 57
            |..::..|:.|...|.|    |.|.   :|.. ||||.::....:|:.:||.||
Human     5 KSALVFLLLQLFCVGCG----FCGKVLVWPCDMSHWLNVKVILEELIVRGHEVTVLTHSKPSLID 65

  Fly    58 ---------SVNNHPTKHPHENLTEIIISPSFDIPKHFPKENIFSMQFVSDFNN--LELWWTIGL 111
                     .|.:.|.....||  ||.:..:.::   .|  .:.:.|.|...|:  :|:..|:.:
Human    66 YRKPSALKFEVVHMPQDRTEEN--EIFVDLALNV---LP--GLSTWQSVIKLNDFFVEIRGTLKM 123

  Fly   112 MTTEHAFKDPKVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGI 176
            |.....:....:|||.|:   :||:::|:.......|| .:....|.|....:....|::.:.|.
Human   124 MCESFIYNQTLMKKLQET---NYDVMLIDPVIPCGDLM-AELLAVPFVLTLRISVGGNMERSCGK 184

  Fly   177 L-TPWSLIPHLLLSHTDRMTFGQRAYNAYLSL--------YDAVMRRWVYLPKMQKLAEKYFQGS 232
            | .|.|.:|..:...||||||.:|..|:.||:        ||  ...|          |:::..:
Human   185 LPAPLSYVPVPMTGLTDRMTFLERVKNSMLSVLFHFWIQDYD--YHFW----------EEFYSKA 237

  Fly   233 IEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLP------TDLQNFLD 291
            :..| ..:.:......:.||..:...:.|:|..|....|||.|.:..|.||      .:::||:.
Human   238 LGRP-TTLCETVGKAEIWLIRTYWDFEFPQPYQPNFEFVGGLHCKPAKALPKINFYLQEMENFVQ 301

  Fly   292 NA-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQN 355
            :: ..|::.||:||..:  ::.:||..:|..|..|:.|:|:|:::......|.:|..:..|:|||
Human   302 SSGEDGIVVFSLGSLFQ--NVTEEKANIIASALAQIPQKVLWRYKGKKPSTLGANTRLYDWIPQN 364

  Fly   356 DILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDL 420
            |:|.||..|.||||||:.|..|.||.||||:.||::|||..|......:|.|..:.|..:|::||
Human   365 DLLGHPKTKAFITHGGMNGIYEAIYHGVPMVGVPIFGDQLDNIAHMKAKGAAVEINFKTMTSEDL 429

  Fly   421 VRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLL 485
            :|.:.|:|.|..||.:|:.:|:...|.|:.|||.|.||||:::||:||:||:|....:...|:..
Human   430 LRALRTVITDSSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRSAAHDLTWFQHYS 494

  Fly   486 LDVLGCLLLGAFLAIWL 502
            :||:|.||.....||:|
Human   495 IDVIGFLLACVATAIFL 511

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_609882.1	Glycosyltransferase_GTB-type	37..483	CDD:471961	143/483 (30%)
UGT2A3	XP_011530549.1	UDPGT	24..528	CDD:278624	154/514 (30%)