DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	538	Identity:	160/538 - (29%)
Similarity:	255/538 - (47%)	Gaps:	68/538 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 MLIFLIGLLEFGAGSRILFM-GPFPAPSHWLWLEHFQNDLLRQGHHVTSV--NNHPTKHPHENLT 72
            ::..|:..::.|...|:|.| |.:   |||..:......|:.:.|.||.:  ::.||. ||..
Zfish     7 LVCLLLCGVDVGWSGRVLVMPGEY---SHWHNMRAIIEALVDRNHSVTVLVSSSSPTV-PHTQ-- 65

  Fly    73 EIIISPSFDIPKHFPKENIFSMQ---FVSDFNNLELW--------------WTIGLMTTEHAFKD 120
                ...||.  |..|.|:...:   ..|||.:  ||              |.:  |:.......
Zfish    66 ----KARFDY--HVFKVNMDKEEAKVIWSDFTH--LWMKETDSKLERGFLIWRV--MSNFRRLAA 120

  Fly   121 PKVKKLIESKD-------DHYDLVIIEQFFHEAFLMFGKRFNCPVVTIGTMGYADNIDHAMGIL- 177
            ...:.|:::.|       .|||::..:.....:.|| .:..|.|.|....:.:|...:...|.:
Zfish   121 DVCRSLLQNDDLLQMLGESHYDVLFSDPMMPCSDLM-AQTLNIPQVISLRLTFAYTFERMCGQMP 184

  Fly   178 TPWSLIPHLLLSH--TDRMTFGQRAYNAYL-SLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLPN 239
            .|.|.:|.:.|:.  ||||:|.:|..|..| .::..|.|    |..|..:...|.:  |.|....
Zfish   185 APPSYVPAVALTDHLTDRMSFMERVENMLLYFIHTTVFR----LNTMLTVDRLYTE--IRGKPTT 243

  Fly   240 VLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYGVIYFSMG 303
            :.:......:.||..:...:.|||..|....|||.|.:..|.|..:::.|:.:: .:||:.||:|
Zfish   244 MCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFVQSSGDHGVVVFSLG 308

  Fly   304 SYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKLFIT 368
            |.:|  :|..|:...|..|.||:.|:|:|::...:...|..|..|..|:||||:|.||..|.|||
Zfish   309 SMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFIT 371

  Fly   369 HGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIETLINDPQY 433
            |||..|..|.||.||||:.:||:.||..|.:....:|.|..|..:.|.:.|||..::|::|:|.|
Zfish   372 HGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPSY 436

  Fly   434 KRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLLGAFL 498
            |.|.:.:|:...|.|:.|||:|.:|||:::|::||:||:.....:..:||..|||...||..|.|
Zfish   437 KESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDVAAFLLSIAAL 501

  Fly   499 AIWLPWRMIRRVHKWWLK 516
            ..:|           |:|
Zfish   502 ITFL-----------WVK 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	148/502 (29%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	142/476 (30%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	158/524 (30%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	88/232 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860