DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and ugt5a2

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001070191.2	Gene:	ugt5a2 / 767756	ZFINID:	ZDB-GENE-061103-373	Length:	524	Species:	Danio rerio

Alignment Length:	488	Identity:	149/488 - (30%)
Similarity:	240/488 - (49%)	Gaps:	37/488 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHEN---LTEIIISPS-FD---IPKHFPKENIFSM 94
            |||:.::....:|..:||.:|.|....:.:..|.   .|.|.:... ||   :.|..|.......
Zfish    32 SHWVNMKVLIVELHSRGHSITVVRGSSSWYIEEQSPLYTSITVDNGVFDDDFMEKFLPHLLKIQR 96

  Fly    95 QFVSDFNNLELW-WTIGLMTTEHAFKDPKVKKLIES-------KDDHYDLVIIEQFFHEAFLMFG 151
            |..|.:|.:.|. ..|..:|..|.........|.|:       ||..||:|:.:..:....|: .
Zfish    97 QGKSFWNEMALADEMIHFVTETHKQSCNMTAILFENETLMNSLKDAAYDVVLTDPAYGSGVLL-A 160

  Fly   152 KRFNCPVV-TIGTMGYAD-NIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRR 214
            .|...|:| .:....|.: :.|.|.   :|.|.:|...|..||:|||.||..|    :...:|.|
Zfish   161 HRLGLPLVYNVRWTVYGEAHFDIAP---SPLSYVPVSGLQLTDKMTFSQRVMN----MMTYIMIR 218

  Fly   215 WVYLPKM----QKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAH 275
            :.|....    |:|.:|||     ||..|...|.::..|.|:....:.:.|||:||.::.:||..
Zfish   219 YKYSKNFGSPYQELTQKYF-----GPNVNFFSLLQDADLWLMRNDFTFEFPRPTMPNVVYMGGFQ 278

  Fly   276 IQKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSI 339
            .:..|.||.||:.|:.:: .:|||..|:|:..  ..|..|....|..||.||.|:|||::.....
Zfish   279 CKPAKPLPGDLEEFVQSSGEHGVIMMSLGTVF--GQLLSELNDEIAAAFAQLPQKVIWRYTGPRP 341

  Fly   340 GDLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVRE 404
            .:|.:|.:|..|:||||:|.||..|||:.|||..|.||.||.|||::.:||..||..|..:...:
Zfish   342 ANLGNNTLIVNWLPQNDLLGHPKTKLFVAHGGTNGLQEAIYHGVPIVGLPLAFDQPDNLSRMRAK 406

  Fly   405 GYARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGAR 469
            |.|:.:.|:.|.....:..::.::::|.|:.:...:|:...|.|:.|||.|.||||:::|::||.
Zfish   407 GTAKIVEFATLDRAVFLEALKEVLHNPSYRENMQRLSKLHHDQPMKPLDRAIFWIEFVMRNKGAP 471

  Fly   470 HLKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWL 502
            ||::....:...:|..:||:..|:|...:.:.|
Zfish   472 HLRAQSFRMSWIEYQSIDVILTLMLMVLVFVLL 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	143/467 (31%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	143/467 (31%)
ugt5a2	NP_001070191.2	UDPGT	22..524	CDD:278624	149/488 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.760