DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and UGT8

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001121646.2	Gene:	UGT8 / 7368	HGNCID:	12555	Length:	541	Species:	Homo sapiens

Alignment Length:	564	Identity:	162/564 - (28%)
Similarity:	264/564 - (46%)	Gaps:	94/564 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 IFLIGLLEFGAGSRILFMGPFPAPSHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHENLTEIIIS 77
            |.|...:.....::|:.:.|....||....:...:.|..:|||                |..::|
Human     9 ILLWSAVGIAKAAKIIIVPPIMFESHMYIFKTLASALHERGHH----------------TVFLLS 57

  Fly    78 PSFDIPKHFPKENIFSMQ-FVSDFNNLELWWTIGLMTTEHAFKDPKVKKL-------IESKD--D 132
            ...||    ...|.:|:| :...||:          ||..||...|::.:       ||..|  |
Human    58 EGRDI----APSNHYSLQRYPGIFNS----------TTSDAFLQSKMRNIFSGRLTAIELFDILD 108

  Fly   133 HY----DLVI-----IEQFFHEAF--LMFGKRFNCPVVTIGTMGYADNIDHA-----------MG 175
            ||    ||::     |:....|.|  |:......|..|....:|    :.:|           :|
Human   109 HYTKNCDLMVGNHALIQGLKKEKFDLLLVDPNDMCGFVIAHLLG----VKYAVFSTGLWYPAEVG 169

  Fly   176 ILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGSIEGPLP-- 238
            ...|.:.:|......||||...||..|..:.|...:...::.|||.:::.:||      ..||
Human   170 APAPLAYVPEFNSLLTDRMNLLQRMKNTGVYLISRLGVSFLVLPKYERIMQKY------NLLPEK 228

  Fly   239 NVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNAT-YGVIYFSM 302
            ::.||....||.::....:::.|||::|.::.|||...:....||.|||.:::.|. :|.:..|.
Human   229 SMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVNGANEHGFVLVSF 293

  Fly   303 GSYVK--STDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHPNVKL 365
            |:.||  |.|:..:    :..|.|:|.|:|||:|......:|.:|..:.:|:||||:|.|..:|.
Human   294 GAGVKYLSEDIANK----LAGALGRLPQKVIWRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKA 354

  Fly   366 FITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVR-EGYARSLVFSKLTTDDLVRNIETLIN 429
            |::|||:....|.||.|||::.:||:|| |.:|:..|: :|....|.:..:|..:|...:..:||
Human   355 FLSHGGLNSIFETIYHGVPVVGIPLFGD-HYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVIN 418

  Fly   430 DPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGCLLL 494
            :|.|::.|.::|:..:|.|.||::...:||:|||||.||.||::....|...||.|||:...|||
Human   419 NPSYRQRAQKLSEIHKDQPGHPVNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLL 483

  Fly   495 GA----FLAIWLPWRMIRRVHKWW-------LKGESSNKLNEGK 527
            ||    ||..|:...:.|::...|       :.|...|.:..||
Human   484 GAALLYFLLSWVTKFIYRKIKSLWSRNKHSTVNGHYHNGILNGK 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	143/507 (28%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	139/483 (29%)
UGT8	NP_001121646.2	Glycosyltransferase_GTB-type	21..502	CDD:415824	154/525 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.810