DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt301D1 and UGT2B17

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_001068.1	Gene:	UGT2B17 / 7367	HGNCID:	12547	Length:	530	Species:	Homo sapiens

Alignment Length:	522	Identity:	157/522 - (30%)
Similarity:	260/522 - (49%)	Gaps:	65/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 WMLIFLIGLLE--FGAGS--RILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNN-------- 61
            ||.:||:..|.  |.:||  ::|.   :|.. |||:.::....:|:::||.|..:.:
Human     5 WMSVFLLMQLSCYFSSGSCGKVLV---WPTEYSHWINMKTILEELVQRGHEVIVLTSSASILVNA 66

  Fly    62 ----------HPTKHPHENLTEIIISPSFDIPKHFPK--ENIFSMQFVSDFNNL-ELWW---TIG 110
                      :||.....:|.:..:       |.|.:  .:|....|.|.|:.| ||.|   ...
Human    67 SKSSAIKLEVYPTSLTKNDLEDFFM-------KMFDRWTYSISKNTFWSYFSQLQELCWEYSDYN 124

  Fly   111 LMTTEHAFKDPK-VKKLIESKDDHY--DLV-----IIEQFFHEAFLMFGKRFNCPVVTIGTMGYA 167
            :...|.|..:.| ::||.|||.|..  |.|     ::.:..:..|| :..||        ::||.
Human   125 IKLCEDAVLNKKLMRKLQESKFDVLLADAVNPCGELLAELLNIPFL-YSLRF--------SVGYT 180

  Fly   168 DNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSLYDAVMRRWVYLPKMQKLAEKYFQGS 232
            .. .:..|.|.|.|.:|.::...:|:|.|.:|..|....||   ...|.....::|..:  |...
Human   181 VE-KNGGGFLFPPSYVPVVMSELSDQMIFMERIKNMIYMLY---FDFWFQAYDLKKWDQ--FYSE 239

  Fly   233 IEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHIQKPKQLPTDLQNFLDNA-TYG 296
            :.|....:.:......:.||..:...:.|||.:|.:..|||.|.:..|.||.:::.|:.:: ..|
Human   240 VLGRPTTLFETMGKAEMWLIRTYWDFEFPRPFLPNVDFVGGLHCKPAKPLPKEMEEFVQSSGENG 304

  Fly   297 VIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIGDLPSNVMIKKWMPQNDILAHP 361
            ::.||:||.:  :::.:|...:|..|..|:.|:|:|:|:......|.||..:.||:||||:|.||
Human   305 IVVFSLGSMI--SNMSEESANMIASALAQIPQKVLWRFDGKKPNTLGSNTRLYKWLPQNDLLGHP 367

  Fly   362 NVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREGYARSLVFSKLTTDDLVRNIET 426
            ..|.||||||..|..|.||.|:||:.:||:.|||.|......:|.|.|:....:::.||:..:::
Human   368 KTKAFITHGGTNGIYEAIYHGIPMVGIPLFADQHDNIAHMKAKGAALSVDIRTMSSRDLLNALKS 432

  Fly   427 LINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARHLKSHGAFIPLHQYLLLDVLGC 491
            :||||.||.:.:::|:...|.|:.|||.|.||||:::||:||:||:.....:...||..|||:..
Human   433 VINDPIYKENIMKLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHNLTWIQYHSLDVIAF 497

  Fly   492 LL 493
            ||
Human   498 LL 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	148/508 (29%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	140/478 (29%)
UGT2B17	NP_001068.1	UDPGT	24..518	CDD:278624	149/503 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8543
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.760