DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt301D1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_001246079.1	Gene:	Ugt301D1 / 35105	FlyBaseID:	FBgn0032684	Length:	530	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	580	Identity:	178/580 - (30%)
Similarity:	265/580 - (45%)	Gaps:	109/580 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KCWMLIFLIGLLEFGAG--SRILFMGPFPAP-SHWLWLEHFQNDLLRQGHHVTSVNNHPTKHPHE 69
            ||....||:.|...|.|  |::|.   :|.. ||||.|:....:|..:||.||.:     |:|
Mouse     5 KCVAAFFLLQLCWAGCGFCSKVLV---WPCDMSHWLNLKTILEELGARGHEVTVL-----KYP-- 59

  Fly    70 NLTEIIISPSFDIPKHFPKENI---------------FSMQFVSDFNNLELWWTIGLMTTEHAFK 119
               .|||..|..||.||  |||               .:...|:...||.||  ....|.:..|.
Mouse    60 ---SIIIDQSKRIPLHF--ENIPLLYEIETAENRLNEIANLAVNVIPNLSLW--EAAKTLQDFFL 117

  Fly   120 DP-------------KVKKLIESKDDHYDLVIIEQFFHEAFLMFGKRFNCPVVTIG--------- 162
            ..             ..|.:.:.:|..||:|:|:                |||..|
Mouse   118 QVTGDFESICRSVLYNQKFMDKLRDAQYDVVVID----------------PVVPCGELVAEVLQI 166

  Fly   163 --------TMGYADNIDHAMGILTPWSLIPHLLLSHTDRMTFGQRAYNAYLSL--------YDAV 211
                    :|||... .|...:..|.|.:|.::...||.|||.:|..|...||        ||..
Mouse   167 PFVYTLRFSMGYYME-KHCGQLPIPLSYVPVVMSELTDNMTFTERVKNMMFSLLFEYWLQQYDFA 230

  Fly   212 MRRWVYLPKMQKLAEKYFQGSIEGPLPNVLDLERNISLVLINAHRSIDLPRPSMPGLIDVGGAHI 276
            .  |          ::::..::..|......:.: ..:.||..:..::.|||.:|....|||.|.
Mouse   231 F--W----------DQFYSETLGRPTTFCKTVGK-ADIWLIRTYWDVEFPRPYLPNFEFVGGLHC 282

  Fly   277 QKPKQLPTDLQNFLDNA-TYGVIYFSMGSYVKSTDLPQEKTALILKAFGQLKQQVIWKFENDSIG 340
            :..|.||.:::.|:.:: .:||:.||:||.||  :|.:||..||.....|:.|:|:|::......
Mouse   283 KPAKPLPKEMEEFVQSSGEHGVVVFSLGSMVK--NLTEEKANLIASVLAQIPQKVLWRYSGKKPA 345

  Fly   341 DLPSNVMIKKWMPQNDILAHPNVKLFITHGGIFGTQEGIYWGVPMLCVPLYGDQHRNTIKSVREG 405
            .|.||..:..|:||||:|.||..|.||||||..|..|.||.||||:.||:.|||..|......:|
Mouse   346 TLGSNTRLFNWIPQNDLLGHPKTKAFITHGGTNGIYEAIYHGVPMVGVPMLGDQPHNIAHMEAKG 410

  Fly   406 YARSLVFSKLTTDDLVRNIETLINDPQYKRSALEVSQRFRDNPIHPLDEATFWIEYIIRHRGARH 470
            .|..:..|.:|:.||:..:..:||:|.||.:|:.:|:...|.|:.|||.|.||||:::||:||:|
Mouse   411 AALKVSISTMTSTDLLSAVRAVINEPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKH 475

  Fly   471 LKSHGAFIPLHQYLLLDVLGCLLLGAFLAIWLPWRMIRRV-HKWWLKGESSNKLNEGKKR 529
            |:.....:...||..|||:|.|||......::..:....| .|.::|  .|.|:...||:
Mouse   476 LRVAAHDLSWFQYHSLDVIGFLLLCVVTLTFIITKFCLFVCQKLYMK--ESKKMGNRKKK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt301D1	NP_001246079.1	egt	12..483	CDD:223071	160/527 (30%)
Ugt301D1	NP_001246079.1	UDPGT	37..483	CDD:278624	152/499 (30%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	167/551 (30%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	98/240 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760